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Gut satiety hormones and hyperemesis gravidarum

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Hyperemesis gravidarum (HG) is described as unexplained excessive nausea and vomiting during pregnancy. Some gut hormones that regulate appetite may have important role in etiopathogenesis of HG and weight changes during pregnancy. In this study, levels of gut satiety hormones were evaluated in pregnant women with HG.

Methods

This prospective case–control study was conducted in 30 women with HG and 30 healthy pregnant women without symptoms of HG. Fasting venous blood samples were taken from all subjects for measurement of plasma gut hormone levels; obestatin (pg/mL), peptide YY (PYY), pancreatic polypeptide (PP) and cholecystokinin (CCK).

Results

Plasma PYY and PP levels were significantly higher in HG group. The most important parameter in diagnosis of HG was plasma PP level. Simple use of PP level led to the diagnosis 91.1 % of HG cases correctly. The single most important parameter in the prediction of HG was also PP level.

Conclusion

Anorexigenic gut hormones might have important role in etiopathogenesis of hyperemesis gravidarum and weight changes during pregnancy.

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Conflict of interest

The authors declared no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Turgut Özal University, Alparslan Türkeş cad. no:57, Ankara, 06510, Turkey

    Aydin Köşüş, Nermin Köşüş & Deniz Hizli

  2. Department of Obstetrics and Gynecology, Cengiz Gokcek State Hospital, Gaziantep, Turkey

    Betül Usluoğullari

  3. Department of Biochemistry, Turgut Özal University, Ankara, Turkey

    Mehmet Namuslu & Abdullah Ayyildiz

Authors
  1. Aydin Köşüş
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  2. Nermin Köşüş
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  3. Betül Usluoğullari
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  4. Deniz Hizli
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  5. Mehmet Namuslu
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  6. Abdullah Ayyildiz
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Correspondence to Nermin Köşüş.

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Köşüş, A., Köşüş, N., Usluoğullari, B. et al. Gut satiety hormones and hyperemesis gravidarum. Arch Gynecol Obstet 292, 1225–1230 (2015). https://doi.org/10.1007/s00404-015-3751-9

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  • DOI: https://doi.org/10.1007/s00404-015-3751-9

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