Skip to main content
SpringerLink
Log in

Association of Helicobacter pylori positivity with the symptoms in patients with hyperemesis gravidarum

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To investigate the relationship between Helicobacter pylori (Hp) positivity and the severity of symptoms of nausea and vomiting in patients diagnosed with hyperemesis gravidarum (HG).

Design

Prospective controlled.

Methods

Ninety patients with the diagnosis of HG below the 20th week gestation, who had no additional disease and 50 pregnant women with no complaints were enrolled in the study. According to the severity of symptoms, the patients were divided into three groups as group I, II and III (mild, moderate and severe, respectively). The Rhode's scoring system was used to determine the severity of HG symptoms. HpIgG and IgM levels were determined in the blood samples and Hp DNA positivity with PCR was investigated in the saliva.

Results

In accordance with the Rhode's scoring system, 15.5 % of the pregnant women had mild, 58.9 % had moderate, and 25.6 % had severe symptoms (group I, II and III, respectively). HpIgG was determined as positive in 78.6, 84.9 and 82.6 % in groups I, II and III, respectively. HpIgM positivity was determined as 26.1 % only in group III (p = 0.847). HpDNA was determined as 7.2, 3.8, and 91.3 % in group I, II, and III, respectively (p<0.01). While HpIgG was positive in 60 %, HpDNA was found to be positive in 2 % and HpIgM was found to be negative in all the pregnant women in the control group.

Conclusion

A positive relationship between the symptoms of HG and Hp positivity was determined using PCR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ismail SK, Kenny L (2007) Review of hyperemesis gravidarum. Best Pract Res Clin Gastroenterol 21(5):755–769

    Article  PubMed  Google Scholar 

  2. Jewell D, Young G (2003) Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev (4):CD000145

  3. Emelianova S, Mazotta P, Einarson A (1999) Prevalence and severity of NVP and effect of vitamin supplementation. ClinInvest Med 22:106–110

    CAS  Google Scholar 

  4. Gadsby R, Barnie-Adshead AM, Jagger C (1993) A prospective study of nausea and vomiting during pregnancy. Br J Gen Pract 43:245–248

    PubMed  CAS  Google Scholar 

  5. O’ Brien B, Zhou Q (1995) Variables related to nausea and vomiting during pregnancy. Birth 22:93–100

    Article  Google Scholar 

  6. Jueckstock JK, Kaestner R (2010) Managing hyperemesis gravidarum: a multinodal challenge. BMC Med 8:46

    Article  PubMed  CAS  Google Scholar 

  7. Frigo P, Lang C, Reisenberger K (1998) Hyperemesis gravidarum associated with Helicobacter pylori seropositivity. Obstet Gynecol 91(4):615–617

    Article  PubMed  CAS  Google Scholar 

  8. O’Connell MP, Poon P, Lindow SW, Robinson DW (1999) Chronic hypokalemia secondary to hyperemesis gravidarum. J Obstet Gynecol 19(5):532

    Article  Google Scholar 

  9. Kocak I, Akcan Y, Ustun C, Demirel C, Cengiz L, Yanık FF (1999) Helicobacter pylori seropositivity in patients with hyperemesis gravidarum. Int J Gynecol Obstet 66:251–254

    Article  CAS  Google Scholar 

  10. Depue RH, Bernstein L, Ross RK (1987) Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome and other maternal factors: sero-epidemiologic study. Am J Obstet Gynecol 156:1137–1141

    Article  PubMed  CAS  Google Scholar 

  11. Walsh JW, Hasler WL, Nugent CE, Owyang C (1966) Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmias in nausea of pregnancy. Am J Physiol 270:506–514

    Google Scholar 

  12. Jarnfelt-Samsioe A (1987) Nausea and vomiting in pregnancy: a review. Obstet Gynecol Surv 42:422–427

    Article  PubMed  CAS  Google Scholar 

  13. Jarnfelt-Samsoie A, Breme K, Eneroth P (1986) Steroid hormones in emetic and non emetic pregnancy. Eur J Obstet Gynecol Reprod Biol 21(2):87–99

    Article  Google Scholar 

  14. Arısan K (1997) Gebelerin küçük şikayetleri. Prepodötik Kadın Doğum, 2. baskı, İstanbul Nobel tıp 304–305

  15. Mori M, Amino N, Tamaki H, Miyai K, Tanizawa O (1988) Morning sickness and thyroid function in normal pregnancy. Obstet Gynecol 72:355–359

    PubMed  CAS  Google Scholar 

  16. Tareen A, Baseer A, Jaffry H, Shafiq M (1995) Thyroid hormone in hyperemesis gravidarum. J Obstet Gynecol 21:497–501

    Article  CAS  Google Scholar 

  17. Palmer R (1973) A psychosomatic study of vomiting of early pregnancy. J Psychosom Res 17:303–308

    Article  PubMed  CAS  Google Scholar 

  18. Fitzgerald C (1968) Nausea and vomiting in pregnancy. Am J Obstet Gynecol 102:135–171

    Google Scholar 

  19. Starks G (1984) Pregnancy-induced hyperemesis: a reassessment of therapy and proposal of a new etiologic theory. Mo Med 81:253–256

    PubMed  CAS  Google Scholar 

  20. Leylek OA, Toyaksi M, Erselcan T, Dokmetas S (1999) Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyrorinemia. Gynecol Obstet Invest 47(4):229–234

    Article  PubMed  CAS  Google Scholar 

  21. Stuijvenberg M, Schabort I, Labadarios D, Nel J (1995) The nutritional status and treatment of patients with hyperemesis gravidarum. Am J Obstet Gynecol 172:1585–1591

    Article  PubMed  Google Scholar 

  22. Schuster K, Bailey L, Dimperio D, Mahan C (1985) Morning sickness and vitamin B6 status of pregnant women. Hum Nutr Clin Nutr 39:75–79

    PubMed  CAS  Google Scholar 

  23. Baylis J, Leeds A, Challacombe D (1983) Persistent nausea and food aversions in pregnancy. Clin Allergy 1:263–269

    Google Scholar 

  24. Golberg D, Szilagyi A, Graves L (2007) Hyperemesis gravidarum and Helicobacter pylori infection: a systematic review. Obstet Gynecol 110(3):695–703

    Article  PubMed  Google Scholar 

  25. Sandven I, Abdelnoor M, Wethe M, Nesheim BI, Vikanes A, Gjonnes H, Melby KK (2008) Helicobacter pylori infection and hyperemesis gravidarum. An institution-based case–control study. Eur J Epidemiol 23(7):491–498

    Article  PubMed  Google Scholar 

  26. Weyermann M, Brenner H, Adler G, Yasar Z, Handke-Vesely A, Grab D, Krienberg R, Rothenbacher D (2003) Helicobacter pylori infection and the occurrence and severity of gastrointestinal symptoms during pregnancy. Am J Obstet Gynecol 189:526–531

    Article  PubMed  Google Scholar 

  27. Hayakawa S, Nakajima N, Karasaki-Suzuki M, Yoshinaga H, Arakawa Y, Satoh K, Yamamoto T (2000) Frequent presence of Helicobacter pylori genome in the saliva of patients with hyperemesis gravidarum. Am J Perinatol 17(5):243–247

    Article  PubMed  CAS  Google Scholar 

  28. Sandven I, Abdelnoor M, Nesheim BI, Melby KK (2009) Helicobacter pylori infection and hyperemesis gravidarum: a systematic review and meta-analysis of case–control studies. Acta Obstet Gynecol Scand 88(11):1190–1200

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

No actual or potential conflict of interest in relation to this article exists.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey

    Arif Güngören & Neslihan Bayramoğlu

  2. Departments of Microbiology and Clinical Microbiology, Medical Faculty of Mustafa Kemal University, Hatay, Turkey

    Nizami Duran

  3. Department of Biotechnology, Institute of Science, Çukurova University, Adana, Turkey

    Mehmet Kurul

  4. Kadın Hastalıkları ve Doğum Polikliniği, Araştırma ve Uygulama Hastanesi, Mustafa Kemal Üniversitesi, Zülüflühan Köyü, Hatay, Turkey

    Arif Güngören

Authors
  1. Arif Güngören
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Neslihan Bayramoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nizami Duran
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mehmet Kurul
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arif Güngören.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Güngören, A., Bayramoğlu, N., Duran, N. et al. Association of Helicobacter pylori positivity with the symptoms in patients with hyperemesis gravidarum. Arch Gynecol Obstet 288, 1279–1283 (2013). https://doi.org/10.1007/s00404-013-2869-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-013-2869-x

Keywords

Search

Navigation