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Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein A (PAPP-A) levels as the biochemical markers of the combined first trimester aneuploidy screening.

Methods

375 pregnant women between 11 and 14 weeks of gestation who were offered routine first trimester prenatal aneuploidy screening and whose thyroid hormone levels (Thyroid stimulating hormone (TSH), free and total thyroxine, free and total triiodothyronine, anti thyroid peroxidase antibody) were measured were assessed. Correlation of free-β-hCG and PAPP-A with maternal thyroid hormones was analyzed.

Results

There was no statistically significant correlation between maternal TSH, free and total thyroxine, free and total triiodothyronine, anti-thyroid peroxidase antibodies and free-β-hCG and PAPP-A as biochemical markers of first trimester aneuploidy screening.

Conclusion

Maternal thyroid function does not seem to affect secretion of fβ-hCG and PAPP-A.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey

    Hakan Aytan, Ahmet C. Caliskan, Fazlı Demirturk, Filiz Erdogan & Zehra Kuzu

  2. Department of Biochemistry, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey

    Semsettin Sahin

  3. Fatih Mah., Adnan Menderes Bulvarı, 30014 Sok., Yalı Apt, 7/14, Mezitli, Mersin, Turkey

    Hakan Aytan

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  1. Hakan Aytan
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  2. Ahmet C. Caliskan
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Correspondence to Hakan Aytan.

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Aytan, H., Caliskan, A.C., Demirturk, F. et al. Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening. Arch Gynecol Obstet 287, 1125–1129 (2013). https://doi.org/10.1007/s00404-013-2712-4

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  • DOI: https://doi.org/10.1007/s00404-013-2712-4

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