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Intraoperative autologous blood transfusion use during radical hysterectomy for cervical cancer: long-term follow-up of a prospective trial

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

A primary operative complication of radical hysterectomy for cervical cancer is hemorrhage. Intraoperative autologous blood transfusion (ABT) may be beneficial in reducing the need for homologous blood transfusion.

Methods

Our institution published a prospective cohort study examining the use of ABT in cervical cancer patients undergoing radical hysterectomy in 1995. Patients who were initially consented to participate in this prospective trial using intraoperative ABT (cell saver) were evaluated with a median follow-up of 3 years. We sought to update this original report with 16-year follow-up data collected from the clinical charts, Tumor Registry, and the Social Security Death Index.

Results

Two groups of patients undergoing radical hysterectomy were compared: patients who received ABT, and those who did not. Of the 71 original patients, all were included in this updated review, with an average follow-up of 12.4 years for both groups. Originally, thirty-one patients received an ABT. In this group, 1 patient was lost to follow-up, and 4 (12.9 %) are deceased including 1 (3 %) with disease. In the non-autologous group, there were 7 (17.5 %) patient deaths, including 3 (7.5 %) with disease. Eighty-three percent were alive after 12 years in both groups. The ABT group had 1 patient (3 %) who developed a secondary malignancy, a colon adenocarcinoma. The non-autologous group had 2 patients (5 %) who developed a secondary malignancy; one patient developed multiple myeloma and one patient developed a verrucous cancer of the tongue.

Conclusions

Autologous blood transfusion during radical hysterectomy for cervical cancer appears safe and effective.

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Division of Gynecologic Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive 4630 JCP, Iowa City, IA, 52242, USA

    David B. Engle, David P. Bender, Koen De Geest, Amina Ahmed & Michael J. Goodheart

  2. Division of Gynecologic Oncology, University of Wisconsin-Madison, Madison, WI, USA

    Joseph P. Connor

  3. Methodist Cancer Center, Omaha, NE, USA

    Peter C. Morris

Authors
  1. David B. Engle
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  2. Joseph P. Connor
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  3. Peter C. Morris
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  4. David P. Bender
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  5. Koen De Geest
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  6. Amina Ahmed
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  7. Michael J. Goodheart
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Corresponding author

Correspondence to Michael J. Goodheart.

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Engle, D.B., Connor, J.P., Morris, P.C. et al. Intraoperative autologous blood transfusion use during radical hysterectomy for cervical cancer: long-term follow-up of a prospective trial. Arch Gynecol Obstet 286, 717–721 (2012). https://doi.org/10.1007/s00404-012-2351-1

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  • DOI: https://doi.org/10.1007/s00404-012-2351-1

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