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Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The vascular endothelial growth factor (VEGF) gene polymorphism has been reported to be associated with endometriosis risk. The purpose of the present study was to perform a comprehensive meta-analysis to explore whether VEGF gene polymorphisms confer risk to endometriosis.

Methods

By searching PubMed and EMBASE databases, a total of 11 studies were identified. Crude odds ratio (OR) and their corresponding 95% confidence intervals (CI) for VEGF gene polymorphisms and endometriosis risk were calculated.

Result

An association of VEGF gene +936TC polymorphism with endometriosis was found (Fixed-effect model: TT + TC vs. CC: OR 1.184, 95% CI 1.027–1.366, P = 0.020; TC vs. CC: OR 1.187, 95% CI 1.024–1.375, P = 0.023. Random-effcet model: TT + TC vs. CC: OR 1.203, 95% CI 1.003–1.443, P = 0.046; TC vs. CC: OR 1.188, 95% CI 1.021–1.382, P = 0.026). No association between VEGF genes −460CT, +405CG, −2578AC, −1154GA polymorphisms and endometriosis was observed.

Conclusion

Our results indicate that VEGF +936TC gene polymorphism is a risk factor for endometriosis, and not −460CT, +405CG, −2578AC, −1154GA.

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Acknowledgments

We thank the following individuals for helpful comments at various stages of the review process: YunFei Cao, Fan Xu.

Conflict of interest

The authors declare that they have no conflicts of interest relevant to the manuscript.

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Authors and Affiliations

  1. Guangxi Medical University, Nanning, Guangxi, People’s Republic of China

    Shoujun Liang & Yujuan Fan

  2. Department of Gynecology, First Affiliated Hospital of Guangxi Medical University, No. 6, Shuangyong Road, Nanning, Guangxi, 530021, People’s Republic of China

    Shoujun Liang, Yin Huang & Yujuan Fan

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  1. Shoujun Liang
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Correspondence to Yujuan Fan.

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Liang, S., Huang, Y. & Fan, Y. Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis. Arch Gynecol Obstet 286, 139–146 (2012). https://doi.org/10.1007/s00404-012-2270-1

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