Abstract
Endometrial adenofibroma is an uncommon mullerian mixed tumor composed of benign epithelial and mesenchymal components. This tumor must be distinguished from other malignant lesions of the uterus, particularly adenosarcoma. The authors report three cases of endometrial adenofibroma and discuss their clinical and histopathologic features. The tumors were diagnosed in patients 31, 55 and 63 years of age. In all three cases polypoid lesions of 13, 2 and 5 cm, respectively, were found in the uterine cavity. A polypectomy was performed in two cases; one patient underwent hysterectomy. Follow-up was available for two patients who are today alive and well.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Mc Cluggage WG, Haller U, Kurman RJ et al (2004) Mixed epithelial and mesenchymal tumours. In: Tavassoli FA, Devilee P (eds) World health organisation classification of tumours. Pathology and genetics tumours of the breast and female genital organs, IARC Press, Lyon, 248–249
Ober WB (1959) Uterine sarcomas: histogenesis and taxonomy. Ann NY Acad Sci 75:568–585
Oshima H, Miyagawa H, Sato Y et al (2002) Adenofibroma of the endometrium after tamoxifen therapy for breast cancer: MR findings. Abdom Imaging 27:592–594
Huang KT, Chen CA, Cheng WF et al (1996) Sonographic characteristics of adenofibroma of the endometrium following tamoxifen therapy for breast cancer: two case reports. Ultrasound Obstet Gynecol 7(5):363–366
Zaloudek CJ, Mc Usa M, Norris HJ (1981) Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. Cancer 48:354–366
Smoot JS, Zaloudek C (1995) Myometrial and stromal lesions of the uterus. Clin Lab Med 1:545–573
Agarwal PK, Chandrawati HN (1991) Adenofibroma of uterus and endocervix. Histopathology 18:79–80
Germer O, Mor C, Segal S (1995) Uterine adenofibroma presenting as a cystic mass. Arch Gynecol Obstet 256:99–101
Horie Y, Ikawa S, Kadowaki K et al (1995) Lipoadenofibroma of the uterine corpus: report of a new variant of adenofibroma (benign Müllerian mixed tumor). Arch Pathol Lab Med 119:274–276
Clement PB, Scully RE (1990) Mullerian adenofibroma of the uterus with invasion of myometrium and pelvic veins. Int J Gynecol Pathol 9(4):363–371
Kerner H, Lichtig C (1993) Müllerian adenosarcoma presenting as cervical polyps: a report of seven cases and review of the literature. Obstet Gynecol 81:655–659
Seltzer VL, Levine A, Spiegel G et al (1990) Adenofibroma of the uterus: multiple recurrences following wide local excision. Gynecol Oncol 37:427–431
Venkatraman L, Elliott H, Steele EK et al (2003) Serous carcinoma arising in an adenofibroma of the endometrium. Int J Gynecol Pathol 22(2):194–197
Miller KN, Mc Clure SP (1992) Papillary adenofibroma of the uterus. Report of a case involved by adenocarcinoma and review of the literature. Am J Clin Pathol 97:806–809
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bettaieb, I., Mekni, A., Bellil, K. et al. Endometrial adenofibroma: a rare entity. Arch Gynecol Obstet 275, 191–193 (2007). https://doi.org/10.1007/s00404-006-0196-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00404-006-0196-1