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Acquired ichthyosis: a clinical review

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Abstract

Acquired ichthyosis (AI) is a rare, nonhereditary cutaneous disorder that has been associated with numerous neoplastic, infectious, drugs, endocrine, metabolic, autoimmune, and malabsorptive diseases. Review all demographical, clinical, histological, and therapeutic features of AI and focus on all reported associated diseases. We performed a systematic literature review in Pubmed/Medline, Embase, and Cochrane collaboration databases, searching for all articles on AI, with no limits on publication date, participant age, sex or nationality. Eighty-four articles were included. Total number of included patients was 167 patients with a mean age at presentation of 39 years [range 0.5–85] and a sex ratio M:F of 5:2. The most common malignancy associated with AI is Hodgkin’s lymphoma. AI occurred before, simultaneously or after the onset of malignancy or systemic disease. The severity of AI depends on the severity of the underlying disorder and regresses once the disease goes into remission and may also be a marker of disease recurrence or relapse. 8% have been reported to be drug related and all occurred weeks to months after drug intake and resolved after stopping or decreasing the dose of the drug. Data were derived from case reports and observational studies. Limitations include the accuracy of published data, potential patient selection, and reporting bias. AI can be associated with numerous systemic diseases and drugs. Physicians should be particularly alert to these associations to provide adequate screening and management of patients with AI.

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Authors and Affiliations

  1. Department of Dermatology, University of Illinois-Chicago, 808 South Wood Street (MC 624), Suite 380 College of Medicine East Tower, Chicago, IL, 60612, USA

    Roger Haber & Brian A. Cahn

  2. Department of Dermatology, Saint George Hospital University Medical Center, Beirut, Lebanon

    Joelle Feghali

  3. Faculty of Medicine, Balamand University, El-Koura, Lebanon

    Joelle Feghali

  4. Department of Dermatology, Feinberg School of Medicine, Chicago, IL, USA

    Umer Nadir & Michael D. Yi

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  1. Roger Haber
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  2. Joelle Feghali
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  3. Umer Nadir
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  4. Michael D. Yi
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  5. Brian A. Cahn
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Contributions

RH, JF, UN, MDY, BAC independently performed a complete and systematic literature review in PubMed/MEDLINE and Embase databases, searching for all articles on AI. RH collected the following descriptive data for each included study. Data extraction was verified by JF. Supplemental articles were provided by UN, MDY, and BAC.

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Correspondence to Brian A. Cahn.

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Haber, R., Feghali, J., Nadir, U. et al. Acquired ichthyosis: a clinical review. Arch Dermatol Res 315, 2529–2543 (2023). https://doi.org/10.1007/s00403-023-02668-5

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