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Non-invasive methods for evaluation of skin manifestations in patients with ichthyosis

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Abstract

Hereditary ichthyoses include a group of diseases characterized by hyperkeratosis, scaling, generalized xerosis, and is frequently associated with erythroderma. They are classified as syndromic and non-syndromic entities. The monitoring of the severity of ichthyosis requires different strategies for immediate analysis, which can comprise visual analogue scales or non-invasive quantitative methods, which collect information on disease progression that may contribute to the management of ichthyosis and aid in delineating clinical trials. In this article, we present a comprehensive review of the existing visual analogue scales, their validation, and their use in studies of disease severity and clinical trials. Interestingly, after many years of study, to date there is not a unanimously accepted tool for assessing the harshness of clinical features. Therefore, we discuss the perspectives of some non-invasive quantitative methods and strategies employed in clinical studies performed in patients with ichthyosis. Advances in these methods provide a rationale of their potential application in the evaluation of ichthyosis severity. Our purpose is to show an overview of non-invasive methodologies for the study of the harshness of ichthyosis.

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References

  1. Vahlquist A, Fischer J, Törmä H (2018) Inherited nonsyndromic ichthyoses: an update on pathophysiology, diagnosis and treatment. Am J Clin Dermatol 19(1):51–66

    Article  PubMed  Google Scholar 

  2. Yoneda K (2016) Inherited ichthyosis: syndromic forms. J Dermatol 43:252–263

    Article  PubMed  Google Scholar 

  3. Marukian NV, Choate KA (2016) Recent advances in understanding ichthyosis pathogenesis. F1000Research 5:1497

    Article  Google Scholar 

  4. Oji V, Preil ML, Kleinow B et al (2017) S1 guidelines for the diagnosis and treatment of ichthyoses—update. J Dtsch Dermatol Ges 15(10):1053–1065

    PubMed  Google Scholar 

  5. Hernandez-Martin A, Aranegui B, Martin-Santiago A, Garcia-Doval I (2013) A systematic review of clinical trials of treatments for the congenital ichthyoses, excluding ichthyosis vulgaris. J Am Acad Dermatol 69(4):544–549

    Article  CAS  PubMed  Google Scholar 

  6. Serup J (1995) EEMCO guidance for the assessment of dry skin (xerosis) and ichthyosis: clinical scoring systems. Skin Res Technol 1(3):109–114

    Article  CAS  PubMed  Google Scholar 

  7. Kuster W, Bohnsack K, Rippke F et al (1998) Efficacy of urea therapy in chidren with ichthyosis. Dermatology 196:217–222

    Article  CAS  PubMed  Google Scholar 

  8. Gånemo A, Virtanen M, Vahlquist A (1999) Improved topical treatment of lamellar ichthyosis: a double-blind study of four different cream formulations. Br J Dermatol 141(6):1027–1032

    Article  PubMed  Google Scholar 

  9. Kamalpour L, Rice ZP, Pavlis M et al (2010) Reliable methods to evaluate the clinical severity of ichthyosis. Pediatr Dermatol 27(2):148–153

    Article  PubMed  Google Scholar 

  10. Bodemer C, Bourrat E, Mazereeuw-Hautier J et al (2011) Short- and medium-term efficacy of specific hydrotherapy in inherited ichthyosis. Br J Dermatol 165(5):1087–1094

    Article  CAS  PubMed  Google Scholar 

  11. Stalder JF, Taieb A, Vieluf D et al (1993) Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 186(1):23–31

    Article  Google Scholar 

  12. Lewis-Jones MS, Finlay AY (1995) The Children’s Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol 132:942–949

    Article  CAS  PubMed  Google Scholar 

  13. Finlay AY, Khan GK (1994) Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use. Clin Exp Dermatol 19:210–216

    Article  CAS  Google Scholar 

  14. Lewis V, Finlay AY (2004) 10 years experience of the Dermatology Life Quality Index (DLQI). J Investig Dermatol Symp Proc 9:169–180

    Article  PubMed  Google Scholar 

  15. Murase C, Takeichi T, Shibata A et al (2018) Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: syndromic forms and quality-of-life analysis in a subgroup. J Dermatol Sci 92(2):127–133

    Article  PubMed  Google Scholar 

  16. Paller AS, Renert-Yuval Y, Suprun M et al (2017) An IL-17-dominant immune profile is shared across the major orphan forms of ichthyosis. J Allergy Clin Immunol 139(1):152–165

    Article  CAS  PubMed  Google Scholar 

  17. Marukian NV, Deng Y, Gan G et al (2017) Establishing and validating an ichthyosis severity index. J Investig Dermatol 137(9):1834–1841

    Article  CAS  PubMed  Google Scholar 

  18. Voegeli R, Rawlings AV, Seroul P, Summers B (2015) A novel continuous colour mapping approach for visualization of facial skin hydration and transepidermal water loss for four ethnic groups. Int J Cosmet Sci 37(6):595–605

    Article  CAS  PubMed  Google Scholar 

  19. Cortés H, Mendoza-Muñoz N, Galván-Gil FA et al (2018) Comprehensive mapping of human body skin hydration: a pilot study. Skin Res Technol. https://doi.org/10.1111/srt.12633

    Article  PubMed  Google Scholar 

  20. Frost P, Weinstein GD, Bothwell JW, Wildnauer R (1968) Ichthyosiform dermatoses. 3. Studies of transepidermal water loss. Arch Dermatol 98(3):230–233

    Article  CAS  PubMed  Google Scholar 

  21. Perusquía-Ortiz AM, Oji V, Sauerland MC, Tarinski T, Zaraeva I, Seller N, Metze D, Aufenvenne K, Hausser I, Traupe H (2013) Complete filaggrin deficiency in ichthyosis vulgaris is associated with only moderate changes in epidermal permeability barrier function profile. J Eur Acad Dermatol Venereol 27(12):1552–1558

    Article  PubMed  Google Scholar 

  22. Winge MC, Hoppe T, Berne B et al (2011) Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris. PLoS ONE 6(12):e28254

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Tomita Y, Akiyama M, Shimizu H (2005) Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis. Exp Dermatol 14(8):619–624

    Article  PubMed  Google Scholar 

  24. Moskowitz DG, Fowler AJ, Heyman MB et al (2004) Pathophysiologic basis for growth failure in children with ichthyosis: an evaluation of cutaneous ultrastructure, epidermal permeability barrier function, and energy expenditure. J Pediatr 145(1):82–92

    Article  CAS  PubMed  Google Scholar 

  25. Malik K, He H, Huynh TN et al (2019) Ichthyosis molecular fingerprinting shows profound Th17-skewing and a unique barrier genomic signature. J Allergy Clin Immunol 143(2):604–618

    Article  CAS  PubMed  Google Scholar 

  26. Hoppe T, Winge MC, Bradley M, Nordenskjöld M, Vahlquist A, Berne B, Törmä H (2012) X-linked recessive ichthyosis: an impaired barrier function evokes limited gene responses before and after moisturizing treatments. Br J Dermatol 167(3):514–522

    Article  CAS  PubMed  Google Scholar 

  27. Hoppe T, Winge MC, Bradley M, Nordenskjöld M, Vahlquist A, Törmä H, Berne B (2015) Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of FLG genotype. J Eur Acad Dermatol Venereol 29(1):174–177

    Article  CAS  PubMed  Google Scholar 

  28. Cortés H, Magaña JJ, Reyes-Hernández OD et al (2019) Non-invasive analysis of skin mechanical properties in patients with lamellar ichthyosis. Skin Res Technol 25(3):375–381

    Article  PubMed  Google Scholar 

  29. Mazereeuw-Hautier J, Vahlquist A, Traupe H et al (2019) Management of congenital ichthyoses: European guidelines of care, part one. Br J Dermatol 180(2):272–281

    Article  CAS  PubMed  Google Scholar 

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Funding

This work was financially supported by a grant from DGAPA-UNAM to Gerardo Leyva-Gómez (Grant number: PAPIIT TA 200318).

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Authors and Affiliations

  1. Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, 14389, Mexico City, Mexico

    Hernán Cortés, Jonathan J. Magaña & Norberto Leyva-García

  2. Unidad Multidisciplinaria de Investigación Experimental Zaragoza (UMIEZ), Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230, Mexico City, Mexico

    Gabriela Figueroa-González

  3. Laboratorio de Biología Molecular del Cáncer, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230, Mexico City, Mexico

    Octavio D. Reyes-Hernández

  4. Facultad de Ciencias Químicas, Universidad Veracruzana, 94340, Orizaba, Veracruz, Mexico

    Lizbeth Cariño-Calvo

  5. Facultad de Medicina, Universidad Veracruzana, 94740, Mendoza, Veracruz, Mexico

    Manuel González-Del Carmen

  6. Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Coyoacán, 04510, Mexico City, Mexico

    Gerardo Leyva-Gómez

Authors
  1. Hernán Cortés
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  2. Gabriela Figueroa-González
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  3. Octavio D. Reyes-Hernández
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  4. Jonathan J. Magaña
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  5. Norberto Leyva-García
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  6. Lizbeth Cariño-Calvo
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  7. Manuel González-Del Carmen
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  8. Gerardo Leyva-Gómez
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Corresponding authors

Correspondence to Manuel González-Del Carmen or Gerardo Leyva-Gómez.

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Cortés, H., Figueroa-González, G., Reyes-Hernández, O.D. et al. Non-invasive methods for evaluation of skin manifestations in patients with ichthyosis. Arch Dermatol Res 312, 231–236 (2020). https://doi.org/10.1007/s00403-019-01987-w

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  • DOI: https://doi.org/10.1007/s00403-019-01987-w

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