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Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate

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Abstract

The G-protein-coupled receptors GPR43 and GPR109a are known to play an important role in mediating anti-inflammatory and anti-cancer functions in the gut. Short-chain fatty acids, such as sodium butyrate (SB), are activators of GPR43 and GPR109a and thereby promote anti-inflammatory effects. The present study aimed to examine the expression of these receptors and their reaction to SB in psoriasis. Lesional and non-lesional biopsies of 6 psoriasis patients and of 4 controls were obtained and stained for GPR109a and GPR43. Ex vivo stimulation with SB was performed on fresh biopsy material. Lesional and non-lesional psoriatic skin showed a decreased expression of GPR109a and GPR43 on keratinocytes in comparison with control skin. Topical application of SB was able to increase the low-level expression of both receptors. The data suggest that SB by restoring the impaired expression of GPR109a and GPR43 might exert anti-inflammatory effects and may be utilized as a topical tool for the treatment of psoriasis, which has to be proven in future clinical trials.

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Abbreviations

GPR:

G-protein-coupled receptor(s)

SB:

Sodium butyrate

SCFA:

Short-chain fatty acids

Treg:

Regulatory T cell(s)

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Acknowledgements

We thank Ms. Katharina Pallasch for excellent technical assistance.

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Authors and Affiliations

  1. Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland

    Alicja Krejner

  2. Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Rosalind-Franklin-Str. 7, Kiel, Germany

    Alicja Krejner, Anika Bruhs, Ulrich Mrowietz, Ulrike Wehkamp, Thomas Schwarz & Agatha Schwarz

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  1. Alicja Krejner
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  2. Anika Bruhs
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  3. Ulrich Mrowietz
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  4. Ulrike Wehkamp
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  5. Thomas Schwarz
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Correspondence to Agatha Schwarz.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Krejner, A., Bruhs, A., Mrowietz, U. et al. Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate. Arch Dermatol Res 310, 751–758 (2018). https://doi.org/10.1007/s00403-018-1865-1

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  • DOI: https://doi.org/10.1007/s00403-018-1865-1

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