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Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis

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Abstract

Oxidative-free radicals and apoptosis have linked to chronic skin diseases. Higher levels of oxidative radicals and the release of mitochondrial cytochrome c may have a role in the pathogenesis of psoriasis. We investigated the possible role of cellular oxidative stress and release of cytochrome c of mitochondria in the pathogenesis of psoriasis. Disease severity was assessed by psoriasis area severity index score (PASI) of 55 psoriasis patients, they grouped as mild (11), moderate (20) and severe (24), also 20 healthy individuals used as controls. All groups were subjected for serum malondialdehyde (MDA), nitric oxide (NO·), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS) and serum cytochrome c concentrations. We found that, (1) Severity wise increase in MDA and NO·, and decrease in SOD, CAT and TAS levels in all patients with different degrees of psoriasis; (2) PASI showed positive correlation with the increase in MDA and NO·, and negatively with decreased SOD, CAT and TAS levels; (3) significant increase in cytochrome c level was observed among psoriasis patients which showed negative correlation to MDA and NO· levels in mild and positively with moderate and severe groups. The release of mitochondrial cytochrome c indicates the induction of apoptosis mediated via oxidative stress which ultimately plays role in the pathogenesis of psoriasis.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Sami A. Gabr

  2. Rehabilitation Research Chair (RRC), King Saud University, Riyadh, Saudi Arabia

    Sami A. Gabr & Ahmad H. Al-Ghadir

  3. Department of Rehabilitation Science, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia

    Ahmad H. Al-Ghadir

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  1. Sami A. Gabr
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  2. Ahmad H. Al-Ghadir
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Correspondence to Sami A. Gabr.

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Gabr, S.A., Al-Ghadir, A.H. Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis. Arch Dermatol Res 304, 451–457 (2012). https://doi.org/10.1007/s00403-012-1230-8

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  • DOI: https://doi.org/10.1007/s00403-012-1230-8

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