Abstract
Recently, a controlled double-blind study in patients with photo-aged facial skin demonstrated the beneficial role of oral intake of silanol for skin, hair and nails. The aim of our pilot study was to investigate histologic alterations in human skin after injection of silanol. Seven healthy female caucasian volunteers with a moderate degree of photoaged skin received ten sessions of weekly injections of 0.1% salicylate silanol in the left ventral lateral forearm. The histologic features of punch biopsies of the treated area and the nontreated contralateral arm were compared and the collagen and elastic fibers quantified. Texture analysis was performed on digitalized microscopic images by analyzing the Sarkar fractal dimension or amplitudes (inertia values) after Fast Fourier transformation. The treated area revealed a statistically significant increase of the density of both collagen and elastic fibers. Texture analysis showed more compact and homogenously distributed collagen fibers after silicon injection. Our results suggest that the application of silicon may stimulate the production of collagen and elastic fibers leading to remodeling of the dermal fiber architecture, which may explain the improvement of the skin surface observed in clinical studies.
References
Adam RL, Corsini TCG, Silva PV, Cintra ML, Leite NJ, Metze K (2004) Fractal dimensions applied to thick contour detection and residues—comparison of keloids and hypertrophic scars. Cytometry A 59:63–64
Adam RL, Silva RC, Pereira FG, Leite NJ, Lorand-Metze I, MetzeK (2006) The fractal dimension of chromatin as prognostic factor in acute B-precursor lymphoid leukemia. Cell Oncol 28:55–59
Auada MP, Adam RL, Leite NJ, Puzzi MB, Cintra ML, Rizzo WB, Metze K (2006) Texture analysis of the epidermis based on the fast Fourier transform in Sjögren—Larsson Syndrome. Anal Quant Cytol Histol 28:219–27
Barel A, Calomme M, Timchenko A, De Paepe K, Demeester N, Rogiers V, Clarys P, Vanden Berghe D (2005) Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. Arch Dermatol Res 297:147–153
Calomme MR, Vanden Berghe D (1997) Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. Biol Trace Elem 56:153–165
Gil J, Barba J (1994) Principles of stereology. Computerized applications to anatomic pathology. In: Marchevsky AM, Bartels PH (eds) Image analysis: a primer for pathologists. Raven Press, New York, pp 79–124
Jelinek HF, Elston N, Zietsch B (2005) Fractal analysis pitfalls and revelations in neuroscience. In: Losa GA, Merlini D Nonnenmacher TF, Weibel ER (eds) Fractals in biology and medicine, vol IV. Birkhüaser, Basel
Metze K, Gomes Neto A, Adam RL, Gomes AA, Leite NJ, Souza EM, Cintra ML (2002) Texture of dermal elastotic tissue in patients with different phenotypes. Anal Cell Pathol 24:196
Metze K, Silva PVVT, Adam RL, Cintra ML, Leite NJ (2002) Differentiation of keloid and hypertrophic scar by texture analysis. Anal Cell Pathol 24:196
Metze K, Adam RL, Silva PVVT, Gomes Neto A, Gomes AA, de Souza EM, Cintra ML, Leite NJ (2003) Application of the new fast Fourier transform derived variables in dermatopathology. Pathol Res Pract 199:242
Metze K, Bedin V, Adam RL, Cintra ML, de Souza EM, Leite NJ (2005) Parameters derived from the fast Fourier transform are predictive for the recurrence of basal cell carcinoma. Cell Oncol 27:137
Reffitt DM, Ogston N, Jugdaohsingh R, Cheung HFJ, Evans BAJ, Thompson RPH, Powell JJ, Hampson GN (2003) Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone 32:127–135
Rocha LB, Adam RL, Leite NJ, Metze K, Rossi MA (2006) Biomineralization of polyanionic collagen-elastin matrices during cavarial bone repair. J Biomed Mater Res A 79:237–245
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Supported by FAEPEX, FAPESP and CNPq.
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Herreros, F.O.C., Cintra, M.L., Adam, R.L. et al. Remodeling of the human dermis after application of salicylate silanol. Arch Dermatol Res 299, 41–45 (2007). https://doi.org/10.1007/s00403-007-0739-8
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DOI: https://doi.org/10.1007/s00403-007-0739-8