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Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity

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Abstract

Generalized pustular psoriasis (GPP) is a rare but notoriously recalcitrant cutaneous diseases. Therefore, there have been few reports of more than ten patients with GPP who were treated at the same institution. The severity of this disease and its response to each therapeutic modality vary among patients. In some GPP is life-threatening, but in others it may show a benign, chronic course for a long period of time. Before starting treatment, a knowledge of the therapeutic efficacy and side effects of each drug used in the treatment of GPP is necessary. In our multicenter study, we compared the effectiveness of and adverse reactions to several systemically administered drugs. Following the development of a unique classification of the disease severity based on scoring the clinical symptoms and the laboratory findings, we propose here therapeutic guidelines for the treatment of GPP.

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Authors and Affiliations

  1. Department of Dermatology, Sensorium and Cutaneous Medicine, Tokai University School of Medicine, Isehara, Japan

    Y. Umezawa & A. Ozawa

  2. Department of Dermatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    T. Kawasima & H. Shimizu

  3. Department of Dermatology, Graduate School of Medicine and School of Medicine, Tohoku University, Sendai, Japan

    T. Terui & H. Tagami

  4. Department of Dermatology, School of Medicine, Juntendo University, Tokyo, Japan

    S. Ikeda & H. Ogawa

  5. Department of Dermatology, School of Medicine, Kinki University, Osaka, Japan

    A. Kawada & T. Tezuka

  6. Dermatological Clinic of Kanto Medical Center, NTT East Corporation, Tokyo, Japan

    A. Igarashi & S. Harada

Authors
  1. Y. Umezawa
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  2. A. Ozawa
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  3. T. Kawasima
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  4. H. Shimizu
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  5. T. Terui
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  6. H. Tagami
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  7. S. Ikeda
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  8. H. Ogawa
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  9. A. Kawada
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  10. T. Tezuka
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  11. A. Igarashi
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  12. S. Harada
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Corresponding author

Correspondence to Y. Umezawa.

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Umezawa, Y., Ozawa, A., Kawasima, T. et al. Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity. Arch Dermatol Res 295 (Suppl 1), S43–S54 (2003). https://doi.org/10.1007/s00403-002-0371-6

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