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Local infiltration analgesia with additional intraarticular catheter provide better pain relief compared to single-shot local infiltration analgesia in TKA

  • Knee Arthroplasty
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Purpose

Local infiltration analgesia (LIA) has been proven to be efficient in total knee arthroplasty (TKA). However, the effect of single-shot LIA is temporarily limited. The objective of this prospective trial was to investigate if the potential benefits resulting from LIA can be prolonged by a continuous intra-articular perfusion of LIA. The hypothesis of the present study was that the use of an additional continuous intra-articular perfusion delivering LIA would result in less pain and better function compared to single-shot LIA in the immediate post-operative period.

Methods

50 consecutively selected patients undergoing TKA received either a single-shot LIA (S-LIA group, 25 knees) or single-shot LIA combined with a continuous post-operative intra-articular perfusion for three post-operative days (CP-LIA group, 25 knees). VAS (visual analogue scale) for pain, pain medication consumption and flexion ability were recorded postoperatively for 6 days. All patients had the same implant, surgeon and intra- as well as post-operative setting.

Results

The VAS score was significantly better for CP-LIA 6 h after surgery and on post-operative day 1, 2 and 6. There was no significant difference with regard to additional opioid consumption or flexion ability of the knee. However, there was a trend of the CP-LIA group requiring less additional opioids over the complete post-operative period compared to the S-LIA group. There were no complications or revisions.

Conclusion

LIA combined with an additional intra-articular catheter provides better short-term pain control compared to single-shot LIA. However, no significant differences in terms of knee flexion were observed. This limited benefit should be balanced against the additional costs and the possible higher risk of infection.

Level of evidence

Level II.

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Abbreviations

TKA:

Total knee arthroplasty

LIA:

Local infiltration analgesia

CP-LIA:

Continuous-perfusion local infiltration analgesia

S-LIA:

Single-shot local infiltration analgesia

ROM:

Range of motion

VAS:

Visual analogue scale

LMWH:

Low-molecular-weight heparins

References

  1. Planckaert C, Larose G, Ranger P et al (2018) Total knee arthroplasty with unexplained pain: new insights from kinematics. Arch Orthop Trauma Surg 138:553–561. https://doi.org/10.1007/s00402-018-2873-5

    Article  PubMed  Google Scholar 

  2. Egloff C, Hügle T, Valderrabano V (2012) Biomechanics and pathomechanisms of osteoarthritis. Swiss Med Wkly 142:w13583. https://doi.org/10.4414/smw.2012.13583

    Article  PubMed  Google Scholar 

  3. Van Manen MD, Nace J, Mont MA (2012) Management of primary knee osteoarthritis and indications for total knee arthroplasty for general practitioners. J Am Osteopath Assoc 112:709–715

    PubMed  Google Scholar 

  4. Michael JW-P, Schlüter-Brust KU, Eysel P (2010) The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Dtsch Arzteblatt Int 107:152–162. https://doi.org/10.3238/arztebl.2010.0152

    Article  Google Scholar 

  5. Society KK (2012) Guidelines for the management of postoperative pain after total knee arthroplasty. Knee Surg Relat Res 24:201–207. https://doi.org/10.5792/ksrr.2012.24.4.201

    Article  Google Scholar 

  6. Toftdahl K, Nikolajsen L, Haraldsted V et al (2007) Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial. Acta Orthop 78:172–179. https://doi.org/10.1080/17453670710013645

    Article  PubMed  Google Scholar 

  7. Essving P, Axelsson K, Åberg E et al (2011) Local infiltration analgesia versus intrathecal morphine for postoperative pain management after total knee arthroplasty: a randomized controlled trial. Anesth Analg 113:926–933. https://doi.org/10.1213/ANE.0b013e3182288deb

    Article  CAS  PubMed  Google Scholar 

  8. Busch CA, Shore BJ, Bhandari R et al (2006) Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial. J Bone Joint Surg Am 88:959–963. https://doi.org/10.2106/JBJS.E.00344

    Article  PubMed  Google Scholar 

  9. Vendittoli P-A, Makinen P, Drolet P et al (2006) A multimodal analgesia protocol for total knee arthroplasty. A randomized, controlled study. J Bone Joint Surg Am 88:282–289. https://doi.org/10.2106/JBJS.E.00173

    Article  PubMed  Google Scholar 

  10. Ong JCA, Chin PL, Lin CP et al (2010) Continuous infiltration of local anaesthetic following total knee arthroplasty. J Orthop Surg Hong Kong 18:203–207. https://doi.org/10.1177/230949901001800214

    Article  PubMed  Google Scholar 

  11. Andersen KV, Bak M, Christensen BV et al (2010) A randomized, controlled trial comparing local infiltration analgesia with epidural infusion for total knee arthroplasty. Acta Orthop 81:606–610. https://doi.org/10.3109/17453674.2010.519165

    Article  PubMed  PubMed Central  Google Scholar 

  12. Reinhardt KR, Duggal S, Umunna B-P et al (2014) Intraarticular analgesia versus epidural plus femoral nerve block after TKA: a randomized, double-blind trial. Clin Orthop 472:1400–1408. https://doi.org/10.1007/s11999-013-3351-6

    Article  PubMed  Google Scholar 

  13. Moghtadaei M, Farahini H, Faiz SH-R et al (2014) Pain management for total knee arthroplasty: single-injection femoral nerve block versus local infiltration analgesia. Iran Red Crescent Med J. https://doi.org/10.5812/ircmj.13247

    Article  PubMed  PubMed Central  Google Scholar 

  14. Nakai T, Tamaki M, Nakamura T et al (2013) Controlling pain after total knee arthroplasty using a multimodal protocol with local periarticular injections. J Orthop 10:92–94. https://doi.org/10.1016/j.jor.2013.02.001

    Article  PubMed  PubMed Central  Google Scholar 

  15. Carli F, Clemente A, Asenjo JF et al (2010) Analgesia and functional outcome after total knee arthroplasty: periarticular infiltration vs continuous femoral nerve block. Br J Anaesth 105:185–195. https://doi.org/10.1093/bja/aeq112

    Article  CAS  PubMed  Google Scholar 

  16. Chaumeron A, Audy D, Drolet P et al (2013) Periarticular injection in knee arthroplasty improves quadriceps function. Clin Orthop 471:2284–2295. https://doi.org/10.1007/s11999-013-2928-4

    Article  PubMed  Google Scholar 

  17. McCartney CJL, McLeod GA (2011) Local infiltration analgesia for total knee arthroplasty. Br J Anaesth 107:487–489. https://doi.org/10.1093/bja/aer255

    Article  CAS  PubMed  Google Scholar 

  18. Zhang S, Wang F, Lu ZD et al (2011) Effect of single-injection versus continuous local infiltration analgesia after total knee arthroplasty: a randomized, double-blind, placebo-controlled study. J Int Med Res 39:1369–1380. https://doi.org/10.1177/147323001103900423

    Article  CAS  PubMed  Google Scholar 

  19. Ali A, Sundberg M, Hansson U et al (2015) Doubtful effect of continuous intraarticular analgesia after total knee arthroplasty: a randomized double-blind study of 200 patients. Acta Orthop 86:373–377. https://doi.org/10.3109/17453674.2014.991629

    Article  PubMed  PubMed Central  Google Scholar 

  20. Blendon RJ, Benson JM (2018) The public and the Opioid-abuse epidemic. N Engl J Med 378:407–411. https://doi.org/10.1056/NEJMp1714529

    Article  PubMed  Google Scholar 

  21. Iseki T, Tsukada S, Wakui M et al (2019) Percutaneous periarticular multi-drug injection at one day after total knee arthroplasty as a component of multimodal pain management: a randomized control trial. BMC Musculoskelet Disord. https://doi.org/10.1186/s12891-019-2451-1

    Article  PubMed  PubMed Central  Google Scholar 

  22. Manchikanti L, Helm S, Fellows B et al (2012) Opioid epidemic in the United States. Pain Physician 15:ES9–38

    PubMed  Google Scholar 

  23. Sabatino MJ, Kunkel ST, Ramkumar DB et al (2018) Excess opioid medication and variation in prescribing patterns following common orthopaedic procedures. J Bone Joint Surg Am 100:180–188. https://doi.org/10.2106/JBJS.17.00672

    Article  PubMed  PubMed Central  Google Scholar 

  24. Wu L, Li M, Zeng Y et al (2020) Prevalence and risk factors for prolonged opioid use after total joint arthroplasty: a systematic review, meta-analysis, and meta-regression. Arch Orthop Trauma Surg. https://doi.org/10.1007/s00402-020-03486-4

    Article  PubMed  Google Scholar 

  25. Mayr HO, Prall WC, Haasters F et al (2019) Pain relieve without impairing muscle function after local infiltration anaesthesia in primary knee arthroplasty: a prospective randomized study. Arch Orthop Trauma Surg 139:1007–1013. https://doi.org/10.1007/s00402-019-03194-8

    Article  CAS  PubMed  Google Scholar 

  26. Uesugi K, Kitano N, Kikuchi T et al (2014) Comparison of peripheral nerve block with periarticular injection analgesia after total knee arthroplasty: a randomized, controlled study. Knee 21:848–852. https://doi.org/10.1016/j.knee.2014.04.008

    Article  PubMed  Google Scholar 

  27. Spangehl MJ, Clarke HD, Hentz JG et al (2015) The Chitranjan Ranawat Award: Periarticular injections and femoral and sciatic blocks provide similar pain relief after TKA: a randomized clinical trial. Clin Orthop 473:45–53. https://doi.org/10.1007/s11999-014-3603-0

    Article  PubMed  Google Scholar 

  28. Goyal N, McKenzie J, Sharkey PF et al (2013) The 2012 Chitranjan Ranawat award: intraarticular analgesia after TKA reduces pain: a randomized, double-blinded, placebo-controlled, prospective study. Clin Orthop 471:64–75. https://doi.org/10.1007/s11999-012-2596-9

    Article  PubMed  Google Scholar 

  29. Niemeläinen M, Kalliovalkama J, Aho AJ et al (2014) Single periarticular local infiltration analgesia reduces opiate consumption until 48 hours after total knee arthroplasty. A randomized placebo-controlled trial involving 56 patients. Acta Orthop 85:614–619. https://doi.org/10.3109/17453674.2014.961399

    Article  PubMed  PubMed Central  Google Scholar 

  30. Yuenyongviwat V, Pornrattanamaneewong C, Chinachoti T, Chareancholvanich K (2012) Periarticular injection with bupivacaine for postoperative pain control in total knee replacement: a prospective randomized double-blind controlled trial. Adv Orthop 2012:107309. https://doi.org/10.1155/2012/107309

    Article  PubMed  PubMed Central  Google Scholar 

  31. Johnson SM, Saint John BE, Dine AP (2008) Local anesthetics as antimicrobial agents: a review. Surg Infect 9:205–213. https://doi.org/10.1089/sur.2007.036

    Article  Google Scholar 

  32. Gómez-Cardero P, Rodríguez-Merchán EC (2010) Postoperative analgesia in TKA: ropivacaine continuous intraarticular infusion. Clin Orthop 468:1242–1247. https://doi.org/10.1007/s11999-009-1202-2

    Article  PubMed  Google Scholar 

  33. J N, V R, G C, T C (2005) Continuous Intra-Articular Infusion of Bupivacaine for Postoperative Pain Following Total Knee Arthroplasty. In: J. Knee Surg. https://pubmed.ncbi.nlm.nih.gov/16152868/. (Accessed 26 May 2020)

  34. M M, P B, J H, et al (2020) Additional periarticular catheter shows no superiority over single-shot local infiltration analgesia alone in unicondylar knee replacement. Knee Surg Sports Traumatol Arthrosc Off J ESSKA. https://pubmed.ncbi.nlm.nih.gov/32303801/. (Accessed 26 May 2020)

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Funding

No funding was received for the present study.

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Authors

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Correspondence to Malin Meier.

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Conflict of interest

The authors MM, SS, JH, CB declare that they have no conflict of interest. The author ET declares that he is providing consultancies for Convatec, KCI, LIMA, Medacta and Zimmer Biomet. He also declares that he receives royalties from LIMA, Medacta and Zimmer Biomet. He further declares that he is part of the euopean knee society board. The author JB declares that he has no conflict of interest, receives honoraria from DePuy, Conformis, Pajunk and Smith and Nephew.

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the ethic committee of the local state medical council (Approv.No. F-2017-024).

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Informed consent was obtained from all individual participants included in this study.

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Meier, M., Sommer, S., Huth, J. et al. Local infiltration analgesia with additional intraarticular catheter provide better pain relief compared to single-shot local infiltration analgesia in TKA. Arch Orthop Trauma Surg 141, 105–111 (2021). https://doi.org/10.1007/s00402-020-03606-0

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  • DOI: https://doi.org/10.1007/s00402-020-03606-0

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