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Platelet-rich plasma did not improve early healing of medial collateral ligament in rats

  • Arthroscopy and Sports Medicine
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Background

The medial collateral ligament (MCL) is the most frequently injured ligament of the knee. Platelet-rich plasma (PRP) is a relatively new treatment option developed to enhance the healing response after injury to different tissue types. This study aimed at investigating whether the addition of PRP to MCL tears in rats would alter healing both biomechanically and histologically.

Methods

Bilateral full-thickness tears of the MCL were surgically induced in the knees of 32 rats. Right ligament was saturated with PRP (n = 32, study group), and the left ligament was saturated with saline (n = 32, control group). The animals were killed 3 weeks later and the surgical sites were evaluated by gross inspection, biomechanically and histologically.

Results

There was no gross difference in the mass of granulation tissue, load to failure, stiffness and displacement between the study and control groups. Histological examination by means of maturity score revealed no significant differences between the study and control groups.

Conclusion

The addition of PRP to a healing MCL did not improve any of the outcome measures in this model.

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Author notes

    Authors and Affiliations

    1. Division of Orthopaedic Surgery, Tel Aviv Sourasky Medical Center, 6 Weizman Street, 64239, Tel Aviv, Israel

      Eyal Amar, Nimrod Snir, Osnat Sher, Morsi Khashan, Moshe Salai & Oleg Dolkart

    2. Pathology Institute, Tel Aviv Sourasky Medical Center, 6 Weizman Street, 64239, Tel Aviv, Israel

      Osnat Sher

    3. Biomechanics Laboratory, School of Dental Medicine, Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel

      Tamar Brosh

    Authors
    1. Eyal Amar
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    2. Nimrod Snir
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    3. Osnat Sher
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    4. Tamar Brosh
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    7. Oleg Dolkart
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    Correspondence to Oleg Dolkart.

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    E. Amar and N. Snir contributed equally to this work.

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    Amar, E., Snir, N., Sher, O. et al. Platelet-rich plasma did not improve early healing of medial collateral ligament in rats. Arch Orthop Trauma Surg 135, 1571–1577 (2015). https://doi.org/10.1007/s00402-015-2306-7

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    • DOI: https://doi.org/10.1007/s00402-015-2306-7

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