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A distinct pattern of Olig2-positive cellular distribution in papillary glioneuronal tumors: a manifestation of the oligodendroglial phenotype?

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Abstract

Mixed neuronal-glial tumors of the central nervous system display a wide spectrum of differentiation. Among them, the papillary glioneuronal tumor (PGNT) is characterized by pseudopapillary structures composed of astroglial cells covering hyalinized vessels, and by neurocytic, ganglioid and ganglion cells. In addition, a “nonspecific” cell type, not similar to either astrocytes or neurocytes, has been recognized since the initial reports. Recently, minigemistocytic cells and a population immunostained by anti-Olig2 antibody have also been recognized in PGNT. Olig2 is a transcription factor that is specific for the cellular phenotype of oligodendrocytes. The aim of this study was to further investigate the histological diversity of PGNT. We examined six cases of PGNT, each of which showed Olig2 immunopositivity. Minigemistocytes were encountered in three cases at close proximity to the Olig2-positive area. Olig2-positive cells were negative for glial fibrillary acidic protein (GFAP) and neuronal nuclear antigen by double immunostaining, and mainly occupied the interpapillary area laterally adjacent to the GFAP-positive cells. They had relatively small, round and vesicular nuclei, and were formerly regarded as neurocytic cells or nonspecific cellular elements. Fluorescence in situ hybridization targeting chromosome 1p failed to demonstrate any deletion. This study disclosed an additional cellular component of PGNT that is characterized by Olig2 positivity, suggestive of oligodendroglial phenotype, and the results also encourage us to investigate oligodendroglial participation in various glioneuronal tumors.

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Acknowledgements

The authors would like to express their gratitude to the following contributors: Dr. Jun-ichi Adachi and Prof. Masao Matsutani (Department of Neurosurgery, Saitama Medical School), and Dr. Makoto Sugiyama (Department of Neurosurgery, Eastern Japan Medical Center). This work was supported in part by Grants-in-Aid for Scientific Research (nos. 15300113 and 14570159) from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

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Authors and Affiliations

  1. Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Gunma, Japan

    Yuko Tanaka, Hideaki Yokoo & Yoichi Nakazato

  2. Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan

    Takashi Komori

  3. Laboratory of Pathology, Makita General Hospital, Tokyo, Japan

    Yoshihisa Makita

  4. Department of Pathology, Saitama Medical School, Saitama, Japan

    Takashi Ishizawa & Takanori Hirose

  5. Department of Neurosurgery, Koshigaya Municipal Hospital, Saitama, Japan

    Michimasa Ebato

  6. Department of Pathology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Junji Shibahara

  7. Department of Pathology, Kurashiki Central Hospital, Okayama, Japan

    Choutatsu Tsukayama

  8. Department of Pathology, Tokai University Hachioji Hospital, Tokyo, Japan

    Makoto Shibuya

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  1. Yuko Tanaka
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Correspondence to Hideaki Yokoo.

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Tanaka, Y., Yokoo, H., Komori, T. et al. A distinct pattern of Olig2-positive cellular distribution in papillary glioneuronal tumors: a manifestation of the oligodendroglial phenotype?. Acta Neuropathol 110, 39–47 (2005). https://doi.org/10.1007/s00401-005-1018-4

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  • DOI: https://doi.org/10.1007/s00401-005-1018-4

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