Abstract
Here we reported the synthesis of polyethylene glycol 2000 monomethyl ether (PEG)ylated hyperbranched poly (amido amine) (h-PAMAM-g-PEG) and the study of an elaborate control over the structure transition by solvents. The double hydrophilic hyperbranched copolymers could form micelles with h-PAMAM core and solvophilic PEG shell in tetrahydrofuran (THF). It was found that the micellization stage was prolonged if more PEG chains were anchored onto h-PAMAM cores. After cross-linking the h-PAMAM cores, well-dispersed hollow spheres were obtained when the micelles were transferred into water from THF. More grafted PEG chains on h-PAMAM may prohibit the creation of a hollow cage upon the swelling of the hydrophilic h-PAMAM cores. Such engineered hollow spheres also retained the pH-sensitive fluorescence characteristic, identical with the luminescent behavior of the free h-PAMAM molecules. H-PAMAM-g-PEG hollow spheres with pH-sensitive fluorescence have a potential application as a drug delivery vehicle for chemotherapy.
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Acknowledgments
We are grateful for the support of the National Science Foundation of China (20874015), the Shanghai Rising-Star Program (10QH1400200), and the Innovation Program of Shanghai Municipal Education Commission (09ZZ01).
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Chen, J., Guo, J., Chang, B. et al. Blue-emitting PEGylated hyperbranched PAMAM: transformation of cross-linked micelles to hollow spheres controlled by the PEG grafting density. Colloid Polym Sci 290, 517–524 (2012). https://doi.org/10.1007/s00396-011-2574-x
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DOI: https://doi.org/10.1007/s00396-011-2574-x