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Thermoresponsive behavior of charged N-isopropylacrylamide-based hydrogels containing gold nanostructures

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Abstract

We report the synthesis of N-isopropylacrylamide-based hydrogels containing either an anionic (acrylic acid) or cationic ([2-(acryloyloxy)ethyl]trimethylammonium chloride) co-monomer. These hydrogels were cross-linked with a cleaveable (N,N′-cystaminebisacrylamide) and/or inert (N,N′-methylenebisacrylamide) molecule in four combinations. Gold nanostructures were then synthesized within these hydrogel matrices by in situ reduction of a metal ion precursor. The resulting eight nanocomposites and their non-gold-containing (native) analogs were characterized with several analytical methods. UV–visible and infrared spectroscopy revealed differences among the samples based largely on the concentration and identity of cross-linking agent. Equilibrium swelling masses and phase transition behavior point to differences among samples on charge of the hydrogel backbone, cross-linker type, and presence or absence of gold nanostructures. A molecular level explanation for these observations is described.

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Acknowledgments

The authors thank Ms. Katherine E. Wagner and Ms. Jessica R. Bell for some methods development with the p(NIPAm-co-ATAC) and p(NIPAm-co-AAc) systems and Ms. Munzarin F. Qayyum for feedback on the manuscript. This work was partially supported by donors of The American Chemical Society Petroleum Research Fund through Grant PRF42899-GB10, by the National Science Foundation (grant CHE-0353813), and by the Department of Chemistry and Brachman Hoffman Program, Wellesley College.

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  1. Alissa D. Agnello

    Present address: North Seattle Community College, 9600 College Way North, Seattle, WA, 98103-3514, USA

Authors and Affiliations

  1. Department of Chemistry, Wellesley College, 106 Central Street, Wellesley, MA, 02481-8203, USA

    Linda M. Guiney, Alissa D. Agnello, Julia C. Thomas, Koko Takatori & Nolan T. Flynn

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  1. Linda M. Guiney
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  2. Alissa D. Agnello
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  3. Julia C. Thomas
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  5. Nolan T. Flynn
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Correspondence to Nolan T. Flynn.

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Guiney, L.M., Agnello, A.D., Thomas, J.C. et al. Thermoresponsive behavior of charged N-isopropylacrylamide-based hydrogels containing gold nanostructures. Colloid Polym Sci 287, 601–608 (2009). https://doi.org/10.1007/s00396-009-2010-7

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  • DOI: https://doi.org/10.1007/s00396-009-2010-7

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