Abstract
Background
Dietary supplements (DS) are largely consumed in Western countries without demonstrating their nutritional benefits and safety in the general population. The aims, in a large population-based study of French adults, were: (1) to compare the prevalence of nutrient intake inadequacy and the proportion of individuals exceeding tolerable upper intake levels (UL) between DS users and non-users, and (2) to quantify the extent of potentially “at-risk” DS use practices (e.g., DS/drugs contraindicated association or use of beta-carotene DS in smokers).
Methods
76,925 participants, 47.6% men and 52.4% women, mean age 46.9 ± 16.3 years were enrolled to the NutriNet-Santé cohort and they completed a quantitative DS questionnaire and three 24 h dietary records. A composition database including > 8000 DS was developed. Variance reduction was applied to estimate usual intakes and analyses were weighted according to the French census data.
Results
Among DS users of the specific nutrient, DS contributed to 41% of total intake for vitamin D in men, 55% in women; and to 20% of total intake for pyridoxine in men, 21% in women. Compared to dietary intakes only, their prevalence of inadequacy was reduced by 11% for vitamin C, 9% for magnesium, 6% for pyridoxine in men, and 19% for calcium, 12% for iron, and 11% for magnesium in women (p < 0.0001). The proportion of subjects exceeding UL reached 6% for iron and 5% for magnesium in men, and 9% for iron in women. 6% of DS users had potentially “at-risk” practices.
Conclusion
While DS use contributed to decrease the prevalence of insufficient intake for several nutrients, it also conveyed excessive intake of iron and magnesium. Besides, a substantial proportion of potentially “at-risk” DS use practices was reported.
Similar content being viewed by others
Abbreviations
- DS:
-
Dietary supplements
- EAR:
-
Estimated average requirement
- OR:
-
Odds ratio
- CI:
-
Confidence interval
- SFA:
-
Saturated fatty acids
- MUFA:
-
Monounsaturated fatty acids
- PUFA:
-
Polyunsaturated fatty acids
References
Clarke TC, Black LI, Stussman BJ et al (2015) Trends in the use of complementary health approaches among adults: United States, 2002–2012. Natl Health Stat Rep 79:1–16
Farina EK, Austin KG, Lieberman HR (2014) Concomitant dietary supplement and prescription medication use is prevalent among US adults with doctor-informed medical conditions. J Acad Nutr Diet 114:1784–1790
Qato DM, Wilder J, Schumm LP et al (2016) Changes in prescription and over-the-counter medication and dietary supplement use among older adults in the United States, 2005 vs 2011. JAMA Intern Med 176:473–482
Flynn A, Hirvonen T, Mensink GB et al (2009) Intake of selected nutrients from foods, from fortification and from supplements in various European countries. Food Nutr Res 53:2038
Marques-Vidal P, Pecoud A, Hayoz D et al (2009) Prevalence and characteristics of vitamin or dietary supplement users in Lausanne, Switzerland: the CoLaus study. Eur J Clin Nutr 63:273–281
Pouchieu C, Andreeva VA, Peneau S et al (2013) Sociodemographic, lifestyle and dietary correlates of dietary supplement use in a large sample of French adults: results from the NutriNet-Sante cohort study. Br J Nutr 110:1480–1491
Skeie G, Braaten T, Hjartaker A et al (2009) Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study. Eur J Clin Nutr 63(Suppl 4):S226–S238
Tetens I, Biltoft-Jensen A, Spagner C et al (2011) Intake of micronutrients among Danish adult users and non-users of dietary supplements. Food Nutr Res 55:7153
ANSES (2017) Etude Individuelle Nationale des Consommations Alimentaires 3 (INCA 3)
ANSES (2009) Etude Individuelle Nationale des Consommations Alimentaires 2 (INCA 2). AFFSA Fr Food Saf Agency Maisons Alfort
Touvier M, Niravong M, Volatier JL et al (2009) Dietary patterns associated with vitamin/mineral supplement use and smoking among women of the E3N-EPIC cohort. Eur J Clin Nutr 63:39–47
Bailey RL, Fulgoni VL, Keast DR, Dwyer JT (2012) Examination of vitamin intakes among US adults by dietary supplement use. J Acad Nutr Diet 112:657–663
An R, Chiu CY, Andrade F (2015) Nutrient intake and use of dietary supplements among US adults with disabilities. Disabil Health J 8:240–249
Murphy SP, White KK, Park SY, Sharma S (2007) Multivitamin-multimineral supplements’ effect on total nutrient intake. Am J Clin Nutr 85:280S–284S
Sebastian RS, Cleveland LE, Goldman JD, Moshfegh AJ (2007) Older adults who use vitamin/mineral supplements differ from nonusers in nutrient intake adequacy and dietary attitudes. J Am Diet Assoc 107:1322–1332
French Agency for Food, Environmental and Occupational Health & Safety (2015) ANSES opinion on the evaluation of the intakes of vitamins and minerals derived from the non-enriched diet, the fortified diet and the dietary supplements in the French population: estimation of the usual intakes, the prevalences of inadequacy and the Risk of exceeding the tolerable upper levels. https://www.anses.fr/fr/system/files/NUT2012sa0142.pdf. Accessed 30 July 2018
Druesne-Pecollo N, Latino-Martel P, Norat T et al (2010) Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. Int J Cancer 127:172–184
Cohen PA, Ernst E (2010) Safety of herbal supplements: a guide for cardiologists. Cardiovasc Ther 28:246–253
de BA, van HF, Bast A (2015) Adverse food-drug interactions. Regul Toxicol Pharmacol 73:859–865
Di LC, Ceschi A, Kupferschmidt H et al (2015) Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality. Br J Clin Pharmacol 79:578–592
Marder VJ (2005) The interaction of dietary supplements with antithrombotic agents: scope of the problem. Thromb Res 117:7–13
Tsai HH, Lin HW, Simon PA et al (2012) Evaluation of documented drug interactions and contraindications associated with herbs and dietary supplements: a systematic literature review. Int J Clin Pract 66:1056–1078
Tsai HH, Lin HW, Lu YH et al (2013) A review of potential harmful interactions between anticoagulant/antiplatelet agents and Chinese herbal medicines. PLoS One 8:e64255-
Wittkowsky AK (2005) A systematic review and inventory of supplement effects on warfarin and other anticoagulants. Thromb Res 117:81–86
Yetley EA (2007) Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability, and drug interactions. Am J Clin Nutr 85:269S–276S
Zablocka-Slowinska K, Jawna K, Grajeta H, Biernat J (2014) Interactions between preparations containing female sex hormones and dietary supplements. Adv Clin Exp Med 23:657–663
Pouchieu C, Fassier P, Druesne-Pecollo N et al (2015) Dietary supplement use among cancer survivors of the NutriNet-Sante cohort study. Br J Nutr 113:1319–1329
Hercberg S, Castetbon K, Czernichow S et al (2010) The Nutrinet-Sante Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional status. BMC Public Health 10:242-
Vergnaud AC, Touvier M, Mejean C et al (2011) Agreement between web-based and paper versions of a socio-demographic questionnaire in the NutriNet-Sante study. Int J Public Health 56:407–417
Lassale C, Peneau S, Touvier M et al (2013) Validity of web-based self-reported weight and height: results of the Nutrinet-Sante study. J Med Internet Res 15:e152
Touvier M, Mejean C, Kesse-Guyot E et al (2010) Comparison between web-based and paper versions of a self-administered anthropometric questionnaire. Eur J Epidemiol 25:287–296
IPAQ Group (2005) Guidelines for data processing and analysis of the international physical activity questionnaire (IPAQ)
Vidal (1997) Dictionnaire VIDAL. VIDAL, Paris
Touvier M, Kesse-Guyot E, Mejean C et al (2011) Comparison between an interactive web-based self-administered 24 h dietary record and an interview by a dietitian for large-scale epidemiological studies. Br J Nutr 105:1055–1064
Lassale C, Castetbon K, Laporte F et al (2015) Validation of a Web-based, self-administered, non-consecutive-day dietary record tool against urinary biomarkers. Br J Nutr 113:953–962
Lassale C, Castetbon K, Laporte F et al (2016) Correlations between fruit, vegetables, fish, vitamins, and fatty acids estimated by web-based nonconsecutive dietary records and respective biomarkers of nutritional status. J Acad Nutr Diet 116:427–438
Le Moulec N, Deheerger M, Preziosi P et al (2016) Validation du manuel-photos utilisé pour l’enquête alimentaire de l’étude SU.VI.MAX
NutriNet-Santé coordination (2013) Table de composition des aliments—Etude NutriNet-Santé. Economica 2013, Paris
Black AE (2000) Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. Int J Obes Relat Metab Disord 24:1119–1130
Black AE (2000) The sensitivity and specificity of the Goldberg cut-off for EI:BMR for identifying diet reports of poor validity. Eur J Clin Nutr 54:395–404
Goldberg GR, Black AE, Jebb SA et al (1991) Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording. Eur J Clin Nutr 45:569–581
INSEE (2016) French National Census Data. Inst Natl Stat Etudes Econ
Carroll RJ, Midthune D, Subar AF et al (2012) Taking advantage of the strengths of 2 different dietary assessment instruments to improve intake estimates for nutritional epidemiology. Am J Epidemiol 175:340–347
Subar AF, Dodd KW, Guenther PM et al (2006) The food propensity questionnaire: concept, development, and validation for use as a covariate in a model to estimate usual food intake. J Am Diet Assoc 106:1556–1563
Tooze JA, Midthune D, Dodd KW et al (2006) A new statistical method for estimating the usual intake of episodically consumed foods with application to their distribution. J Am Diet Assoc 106:1575–1587
Carriquiry AL (1999) Assessing the prevalence of nutrient inadequacy. Public Health Nutr 2:23–33
Martin A (2001) Apports nutritionnels conseille´s pour la population française (Recommended Dietary Allowances for the French Population), 3rd edn. Tec & Doc Lavoisier, Paris
EFSA (2013) Scientific opinion on dietary reference values for vitamin C. EFSA J 11:68
NNR (2012) Nordic nutrition recommendations 2012. No Nord 2014:002
IOM (2011) Dietary intakes for calcium and vitamin D. Institute of Medicine, National Academies Press, Washington, DC
SCF (2000) Opinion of the scientific committee on food on the tolerable upper intake level of selenium
SCF (2002) Opinion of the scientific committee on food on the tolerable upper intake level of iodine
SCF (2002) Opinion of the scientific committee on food on the tolerable upper intake level of selenium
SCF (2003) Opinion of the scientific committee on food on the tolerable upper intake level of calcium
SCF (2003) Opinion of the scientific committee on food on the tolerable upper intake level of copper
Touvier M, Kesse E, Clavel-Chapelon F, Boutron-Ruault MC (2005) Dual Association of beta-carotene with risk of tobacco-related cancers in a cohort of French women. J Natl Cancer Inst 97:1338–1344
Kellermann AJ, Kloft C (2011) Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy 31:490–502
Kim JM, White RH (1996) Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 77:545–546
Meydani SN, Meydani M, Blumberg JB et al (1998) Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults. Am J Clin Nutr 68:311–318
Aparicio-Ugarriza R, Luzardo-Socorro R, Palacios G et al (2018) What is the relationship between physical fitness level and macro- and micronutrient intake in Spanish older adults? Eur J Nutr. https://doi.org/10.1007/s00394-018-1696-z
Food and Nutrition Board (1997) Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Institute of Medicine (IOM), National Academy Press, Washington, DC
Food and Nutrition Board (2001) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc: a report of the panel on micronutrients. National Academy Press, Washington, DC
AICR/WCRF (2007) (2016) American Institute for Cancer Research/ World Cancer Research Fund. Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective. Washington
Latino-Martel P, Bachmann P (2012) Antioxydative nutritional supplements throughout the cancer treatment process. Nutr Clin Metab 26:238–246
Robinson A, McGrail MR (2004) Disclosure of CAM use to medical practitioners: a review of qualitative and quantitative studies. Complement Ther Med 12:90–98
Andreeva VA, Salanave B, Castetbon K et al (2015) Comparison of the sociodemographic characteristics of the large NutriNet-Sante e-cohort with French Census data: the issue of volunteer bias revisited. J Epidemiol Community Health 69:893–898
Verdot C, Torres M, Salanave B, Deschamps V (2017) Corpulence des enfants et des adultes en France métropolitaine en 2015. Résultats de l’étude Esteban et évolution depuis 2006. Bull Epidémiol Hebd 13:234–41
Acknowledgements
The authors thank all the volunteers of the NutriNet-Santé cohort. We extend special thanks to Ludivine Ursule, Cédric Agaesse, Claudia Chahine, Marion Genest and Anne-Elise Dussouiler, dietitians, for the elaboration of the DS composition database. We also thank Véronique Gourlet, Nathalie Arnault, Stephen Besseau, Laurent Bourhis, Yasmina Chelghoum, Than Duong Van, Younes Esseddik, Paul Flanzy, Julien Allègre, Mac Rakotondrazafy, Fabien Szabo, Roland Andrianasolo, and Fatoumata Diallo for their technical contribution to the NutriNet-Santé study. This work was conducted in the framework of the French network for Nutrition and Cancer Research (NACRe network), https://www6.inra.fr/nacre/.
Funding
This work was funded by the Cancéropôle Ile de France/Région Ile de France. Philippine Fassier and Mélanie Deschasaux were funded by PhD grants from the Cancéropôle Ile de France/Région Ile-de-France. The NutriNet-Santé study was supported by the following public institutions: Ministère de la Santé, Institut de Veille Sanitaire (InVS), Institut National de la Prévention et de l’Education pour la Santé (INPES), Région Ile-de-France (CORDDIM), Fondation pour la Recherche Médicale (FRM), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA), Conservatoire National des Arts et Métiers (CNAM) and Université Paris 13.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Fassier, P., Egnell, M., Pouchieu, C. et al. Quantitative assessment of dietary supplement intake in 77,000 French adults: impact on nutritional intake inadequacy and excessive intake. Eur J Nutr 58, 2679–2692 (2019). https://doi.org/10.1007/s00394-018-1815-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00394-018-1815-x