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Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults

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Abstract

Purpose

Quercetin is one of potential antidiabetic substances because of its powerful antioxidant and anti-inflammatory actions. The purpose of this study is to estimate daily quercetin intake and assess the relationship between dietary quercetin intake and the prevalence of type 2 diabetes mellitus (T2DM) in a Chinese population.

Methods

Dietary intake was investigated by a validated 100-item food frequency questionnaire. Daily intakes of quercetin and nutrients were calculated accordingly. T2DM was diagnosed based on the criteria of the American Diabetes Association. Adjusted logistic regression models were used to analyze the relationship between the quartiles of quercetin intake and the prevalence of T2DM.

Results

The prevalences of T2DM were 8.35% in men and 4.68% in women. The main food sources of quercetin were apple, orange, and green tea. Daily intake of quercetin was 20.9 ± 2.32 mg/day (mean ± SD). After adjusting for potentially confounding factors, the odds ratios (95% CI) for T2DM across the ascending quartiles of quercetin intake were: 1.00 (reference), 0.75 (0.60–0.95), 0.76 (0.59–0.99), and 0.63 (0.51–0.94).

Conclusions

The results of the present study showed that quercetin intake was inversely related to the prevalence of T2DM in the Chinese population, suggesting a protective effect of quercetin in the development of T2DM.

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Acknowledgements

The authors gratefully acknowledge all the people that have made this study. This work was supported financially by grants from the Tianjin Research Program of Application Foundation and Advanced Technology (Project no. 13JCQNJC11800), the National Natural Science Foundation of China (nos. 81673166, 81372118, 81372467 and 81302422), and the key technologies R&D program of Tianjin (Key Project: nos. 11ZCGYSY05700, 12ZCZDSY20400, 13ZCZDSY20200, and 15YFYZSY00020).

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Authors and Affiliations

  1. Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, No. 1, Dali Road, Heping District, Tianjin, 300050, China

    Zhanxin Yao, Weina Gao & Changjiang Guo

  2. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300070, China

    Zhanxin Yao, Yeqing Gu, Ge Meng, Hongmei Wu, Yang Xia, Xue Bao, Yuntang Wu & Kaijun Niu

  3. Health Management Center, Tianjin Medical University General Hospital, Tianjin, 300050, China

    Qing Zhang, Li Liu, Hongbin Shi, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia & Kun Song

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Contributions

ZY, CG and KN contributed to the study conception and design. ZY, YG, QZ, LL, GM, HW, YX, XB, HS, SS, XW, MZ, QJ, YW, KS, WG, CG, and KN contributed to data collection, assembly, analysis and interpretation of the data. ZY, KN and CG contributed to drafting of the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Changjiang Guo or Kaijun Niu.

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Yao, Z., Gu, Y., Zhang, Q. et al. Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults. Eur J Nutr 58, 819–830 (2019). https://doi.org/10.1007/s00394-018-1713-2

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