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Vaskulitis-Mimics

Vasculitis mimics

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Zusammenfassung

Vaskulitis-Mimics sind von den primären und sekundären Vaskulitiden gemäß der Chapel-Hill-Nomenklatur abzugrenzen. Ihre Klinik ähnelt der einer Vaskulitis kleiner oder mittlerer, manchmal auch großer Gefäße und imitiert so die entsprechenden klassischen Krankheitsbilder. Ursache sind teilweise genetische Mutationen, Embolisationssyndrome, Infektionen oder auch Substanzabusus. Auch B‑Zell-Lymphome können eine Vaskulitis imitieren. In der vorliegenden Arbeit werden die entsprechenden Vaskulitis-Mimics zusammengefasst.

Abstract

Vasculitis mimics need to be differentiated from primary and secondary vasculitides as described in the Chapel Hill nomenclature. The clinical symptomatology resembles that of vasculitis of small and medium, rarely also large vessels and hence imitates the classical vasculitic disorders. Pathogenetically, the causes are partly genetic mutations, embolization syndromes, infections and substance abuse. Also, B‑cell lymphomas can mimic vasculitis. The present manuscript summarizes the vasculitis mimics.

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Literatur

  1. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC et al (2013) 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1–11

    Article  CAS  Google Scholar 

  2. Venturelli C, Jeannin G, Sottini L, Dallera N, Scolari F (2006) Cholesterol crystal embolism (atheroembolism). Heart Int 2:155

    Article  Google Scholar 

  3. Ghanem F, Vodnala D, Kalavakunta JK, Durga S, Thormeier N et al (2017) Cholesterol crystal embolization following plaque rupture: a systemic disease with unusual features. J Biomed Res 31:82–94

    PubMed  PubMed Central  Google Scholar 

  4. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G et al (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464:1357–1361

    Article  CAS  Google Scholar 

  5. Martinon F, Pétrilli V, Mayor A et al (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237–241

    Article  CAS  Google Scholar 

  6. Csernok E, Lamprecht P, Gross WL (2010) Clinical and immunological features of drug-induced and infection-induced proteinase 3‑antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis. Curr Opin Rheumatol 22:43–48

    Article  CAS  Google Scholar 

  7. Trimarchi M, Gregorini G, Facchetti F et al (2001) Cocaine-induced midline destructive lesions: clinical, radiographic, histopathologic and serologic features and their differentiation from Wegner granulomatosis. Medicine (Baltimore) 80:391–404

    Article  CAS  Google Scholar 

  8. McGrath MM, Isakova T, Rennke HG et al (2011) Contaminated cocaine and antineutrophil cytoplasmic antibody-associated disease. Clin J Am Soc Nephrol 6:2799–2805

    Article  Google Scholar 

  9. Casale JF, Corbel EM, Hays PA (2008) Identification of levamisole impurities found in illicit cocaine exhibits. Microgram J 6:134–137

    Google Scholar 

  10. Guntupalli L, Patel K, Faraji F, Brunworth JD (2017) Autoimmune-related nasal septum perforation: a case report and systematic review. Allergy Rhinol (Providence) 8:40–44

    Article  Google Scholar 

  11. Schultz H, Schinke S, Weiss J, Cerundolo V, Gross WL, Gadola S (2003) BPI-ANCA in transporter associated with antigen presentation (TAP) deficiency: possible role in susceptibility to Gram-negative bacterial infections. Clin Exp Immunol 133:252–259

    Article  CAS  Google Scholar 

  12. Langlois V, Lesourd A, Girszyn N, Ménard JF, Levesque H et al (2016) Antineutrophil cytoplasmic antibodies associated with infective endocarditis. Medicine (Baltimore) 95(3):e2564

    Article  CAS  Google Scholar 

  13. Aslangul E, Goulvestre C, Mallat Z, Mainardi JL (2014) Human bartonella infective endocarditis is associated with high frequency of antiproteinase 3 antibodies. J Rheumatol 41:408–410

    Article  Google Scholar 

  14. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M et al (2012) A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol 22:1–14

    Article  CAS  Google Scholar 

  15. Holle JU, Gross WL, Holl-Ulrich K, Ambrosch P, Noelle B et al (2010) Prospective long-term follow-up of patients with localised Wegener’s granulomatosis: does it occur as persistent disease stage? Ann Rheum Dis 69:1934–1939

    Article  Google Scholar 

  16. Holle JU, Dubrau C, Herlyn K, Heller M, Ambrosch P et al (2012) Rituximab for refractory granulomatosis with polyangiitis (Wegener’s granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations. Ann Rheum Dis 71:327–333

    Article  CAS  Google Scholar 

  17. Badawi RA, Brent LA, Feinstein DE (2009) Mimics of vasculitis: vascular Ehlers-Danlos Syndrome masquerading as polyarteritis nodosa. J Rheumatol 36:1854–1846

    Article  Google Scholar 

  18. Meester JAN, Verstraeten A, Schepers D, Alaerts M, van Laer L, Loeys BL (2017) Differences in manifestation of Marfan syndrome, Ehlers-Danlos syndrome and Loeys-Dietz syndrome. Ann Thorac Surg 6:582–594

    Google Scholar 

  19. Hashem H, Kelly SJ, Ganson NJ, Hershfield MS (2017) Deficiency of Adenosine Deaminase 2 (DADA 2), an inherited cause of polyarteritis nodosa and a mimic of other systemic rheumatologic disorders. Curr Rheumatol Rep 19:70

    Article  Google Scholar 

  20. Meyts I, Aksentijevitch I (2018) Deficiency of adenosine deaminase 2 (DADA2): updates on phenotype, genetics, pathogenesis, and treatment. J Clin Immunol 38:569–578

    Article  CAS  Google Scholar 

  21. Prayson JA (2016) Intravascular lymphoma mimicking vasculitis. J Clin Neurosci 34:224–225

    Article  Google Scholar 

  22. Schaafsma JD, Hui F, Wisco D, Staugaitis SM, Uchino K, Kouzmicheva E, Jaigobin C, Hazrati L‑N, Mikoulis DJ, Mandell DM (2017) High-resolution vessel-wall MRI. Clin Neuroradiol 27:105–108

    Article  Google Scholar 

  23. Ponzoni M, Campo E, Nakamura S (2018) Intravascular large B cell lymphoma a chaaeleon with multiple faces and many masks. Blood 132:1561–1567

    Article  CAS  Google Scholar 

  24. Kalfa M, Kocanaogullan H, Karabulut G, Emmungli H, Cinar C, Yilmaz Z, Gucenmez S, Kabasakal Y (2016) Segemntal arterial mediolysis mimics systemic vasculitis. Eur J Rheumatol. https://doi.org/10.5152/eurjrheum.2015.0047

    Article  PubMed  PubMed Central  Google Scholar 

  25. Shenouda M, Riga C, NaJl Y, Renton S (2014) Segmental arterial mediolysis: a systematic review of 85 cases. Ann Vasc Surg 28:269–277

    Article  Google Scholar 

  26. Leccese P, Yazici Y, Olivieri I (2017) Behcet’s syndrome in nonendemic regions. Curr Opin Rheumatol 29:12–16

    Article  Google Scholar 

  27. International Team for the Revision of the International Criteria for Behçet’s Disease (ITR-ICBD), Davatchi F, Assaad-Khalil S, Calamia KT et al (2013) The International Criteria for Behçet’s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 28:338–347

    Article  Google Scholar 

  28. Everikoglu C (2006) Diagnostic dilemma between intestinal Behcet disease and inflammatory bowel disease with erythema nodosum. World J Gastroenterol 12:5748–5751

    Article  Google Scholar 

  29. Matsumiya W, Kusuhara S, Yamada Y, Atsumi A, Negi A (2012) Sweet’s syndrome with panuveitis resembling Behcet’s disease. Jpn J Ophthalmol 56:268–272

    Article  Google Scholar 

  30. Liu YC, Desai A, Lee B, Srinivasan M (2010) It’s not Behcet’s! J Gen Intern Med 26:559–560

    Article  CAS  Google Scholar 

  31. Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T (2018) Current perspectives on erythema multiforme. Clin Rev Allergy Immunol 54:177–184

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Rheumatologie, Klinische Immunologie, Nephrologie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland

    I. Kötter

  2. Internistisch-rheumatologische Praxis, Jürgensallee 44, 22609, Hamburg, Deutschland

    E. Reinhold-Keller

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  1. I. Kötter
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  2. E. Reinhold-Keller
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Correspondence to I. Kötter.

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I. Kötter und E. Reinhold-Keller geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Für Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, über die Patienten zu identifizieren sind, liegt von ihnen und/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.

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I. Kötter, Hamburg

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Kötter, I., Reinhold-Keller, E. Vaskulitis-Mimics. Z Rheumatol 78, 24–30 (2019). https://doi.org/10.1007/s00393-018-0581-8

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  • DOI: https://doi.org/10.1007/s00393-018-0581-8

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