Zusammenfassung
Die Riesenzellarteriitis (RZA) manifestiert sich häufig als kraniale Arteriitis (z. B. Temporalarteriitis) mit Kopf- und Kauschmerzen sowie Sehstörungen. Nicht selten besteht jedoch auch eine extrakranielle Beteiligung, sodass die RZA gehäuft zu Aortenaneurysmen, Aortendissektionen und zu Stenosen der großen thorakalen, abdominellen oder der Extremitätenarterien führen kann. Begleitet wird die vaskulitische Symptomatik von unspezifischen Allgemeinbeschwerden (Malaise, erhöhte Temperaturen, Gewichtsabnahme, Depressionen), die bei älteren Menschen (>50 Jahre) an eine RZA denken lassen müssen. Die Polymyalgia rheumatica (PMR) stellt die häufigste rheumatische Manifestation der RZA dar, kann aber auch unabhängig von ihr auftreten. Als strukturelles Korrelat der PMR-Beschwerden kommen in erster Linie extraartikuläre Entzündungen (Tenosynovitis, Bursitis) großer Gelenke und der Wirbelsäule (interspinale Bursitis) in Betracht. Bei hoher Entzündungsaktivität der PMR muss zusätzlich an vaskulitische Entzündungen großer Gefäße gedacht werden. Während spezifische Laborparameter für die RZA und die PMR fehlen, haben erhöhte BSG- und CRP-Werte bei der Erstdiagnose eine hohe Sensitivität dieser relativ häufigen, Kortison-sensitiven Erkrankung des älteren Menschen. Neben der Klinik stellt die serologische Akute-Phase-Reaktion den wesentlichen Verlaufsparameter unter der Therapie dar.
Abstract
Giant cell arteritis (GCA) frequently appears as cranial arteritis (eg. temporal arteritis) with headache, pain on chewing and visual disturbances. In addition, extracranial manifestations are often observed leading to aneurysmatic dilatations and dissections of the aorta as well as stenoses of large thoracic, abdominal or limb arteries. The vascular signs are accompanied by general disease symptoms, e.g. malaise, elevated temperatures, weight loss and depression. Polymyalgia rheumatica (PMR) is the most frequent rheumatic manifestation of GCA but also occurs independently from GCA. The structural correlate for the PMR symptoms is first and foremost extra-articular inflammation (tenosynovitis, bursitis) of large joints and the vertebral column (interspinal bursitis). In addition, vasculitis of large arteries in PMR must be considered particularly in the presence of high inflammatory activity. While specific laboratory markers for GCA and PMR are lacking elevated values for the erythrocyte sedimentation rate and C-reactive protein are present in almost all patients at disease onset. Besides the clinical evaluation, the serological acute phase reaction represents the main parameter for the course during therapy of this relatively frequent disease in elderly people.
Notes
Bei Vorliegen von mindestens 3 Kriterien kann die Diagnose einer RZA gestellt werden. Die dargestellten Kriterien haben gegenüber anderen Vaskulitiden eine Sensitivität von 93,5% und eine Spezifität von 91,2%.
Wahrscheinliche PMR: 3 Kriterien oder Koexistenz von einem Kriterium plus Temporalarteriitis.
Literatur
Agard C, Barrier JH, Dupas B et al (2008) Aortic involvement in recent-onset giant cell (temporal) arteritis: a case-control prospective study using helical aortic computed tomodensitometric scan. Arthritis Rheum 59:670–676
Assicot M, Gendrel D, Carsin H et al (1993) High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341:515–518
Bird HA, Esselinckx W, Dixon AS et al (1979) An evaluation of criteria for polymyalgia rheumatica. Ann Rheum Dis 38:434–439
Blockmans D, De Ceuninck L, Vanderschueren S et al (2007) Repetitive 18-fluorodeoxyglucose positron emission tomography in isolated polymyalgia rheumatica: a prospective study in 35 patients. Rheumatology 46:672–677
Blockmans D, De Ceuninck L, Vanderschueren S et al (2006) Repetitive 18-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a prospective study in 35 patients. Arthritis Rheum 55:131–137
Blockmans D, Coudyzer W, Vanderschueren S et al (2008) Relationship between fluorodeoxyglucose uptake in the large vessels and late aortic diameter in giant cell arteritis. Rheumatology 47:1179–1184
Bongartz T, Matteson EL (2006) Large-vessel involvement in giant cell arteritis. Curr Opin Rheumatol 18:10–17
Cantini F, Niccoli L, Nannini C et al (2008) Diagnosis and treatment of giant cell arteritis. Drugs Aging 25:281–297
Caselli R, Hunder GG, Whisnant JP (1988) Neurologic diease in biopsy-proven giant cell (temporal) arteritis. Neurology 38:352–359
Chuang TY, Hunder GG, Ilstrup DM, Kurland LT (1982) Polymyalgia rheumatica: a 10-year epidemiologic and clinical study. Ann Intern Med 97:672–680
Cid MC, Hernandez-Rodriguez J, Esteban MJ et al (2002) Tissue and serum angiogenic activity is associated with low prevalence of ischemic complications in patients with giant-cell arteritis. Circulation 106:1664–1671
Costello F, Zimmerman MB, Podhajsky PA et al (2004) Role of thrombocytosis in diagnosis of giant cell arteritis and differentiation of arteritic from non-arteritic anterior ischemic optic neuropathy. Eur J Ophthalmol 14:245–257
Eberhard OK, Haubitz M, Brunkhorst FM et al (1997) Usefulness of procalcitonin for differentiation between activity of systemic autoimmune disease (systemic lupus erythematosus/systemic antineutrophil cytoplasmic antibody-associated vasculitis) and invasive bacterial infection. Arthritis Rheum 40:1250–1256
Gonzalez-Gay MA, Lopez-Diaz MJ, Barros S et al (2005) Giant cell arteritis: laboratory tests at the time of diagnosis in a series of 240 patients. Medicine (Baltimore) 84:277–290
Hachulla E, Boivin V, Pasturel-Michon U et al (2001) Prognostic factors and long-term evolution in a cohort of 133 patients with giant cell arteritis. Clin Exp Rheumatol 19:171–176
Hachulla E, Saile R, Parra HJ et al (1991) Serum amyloid A concentrations in giant-cell arteritis and polymyalgia rheumatica: a useful test in the management of the disease. Clin Exp Rheumatol 9:157–163
Hellmann DB (2004) Low-dose aspirin in the treatment of giant cell arteritis. Arthritis Rheum 50:1026–1027
Hernandez-Rodriguez J, Garcia-Martinez A, Casademont J et al (2002) A strong initial systemic inflammatory response is associated with higher corticosteroid requirements and longer duration of therapy in patients with giant-cell arteritis. Arthritis Rheum 47:29–35
Hunder GG, Bloch DA, Michel BA et al (1990) The American college of rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 33:1122–1128
Klein RG, Hunder GG, Stanson AW, Sheps SG (1975) Large artery involvement in giant cell (temporal) arteritis. Ann Intern Med 83:806–812
Larson TS, Hall S, Hepper NG, Hunder GG (1984) Respiratory tract symptoms as a clue to giant cell arteritis. Ann Intern Med 101:594–597
Mahr AD, Jover JA, Spiera RF et al (2007) Adjunctive methotrexate for treatment of giant cell arteritis. An individual patient data meta-analysis. Arthritis Rheum 56:2789–2797
Matteson EL, Gold KN, Bloch DA, Hunder GG (1996) Long-term survival of patients with giant cell aretritis in the American college of rheumatology giant cell aretritis classification criteria cohort. Am J Med 100:193–196
Myklebust G, Gran JT (1996) A prospective study of 287 patients with polymyalgia rheumatica and temporal arteritis: clinical and laboratory manifestations at onset of disease and at the time of diagnosis. Br J Rheumatol 35:1161–1168
Nordborg E, Nordborg C (2003) Giant cell arteritis: epidemiological clues to its pathogenesis and an update on its treatment. Rheumatology 42:413–421
Nordborg E, Bengtssson BA (1989) Death rates and causes of death in 284 consecutive patients with giant cell arteritis confirmed by biopsy. Br Med J 299:549–540
Nuenninghoff DM, Hunder GG, Christianson TJH et al (2003) Incidence and predictors of large-artery complication (aortic aneurysm, aortic dissection and/or large artery stenosis) in patients with giant cell arteritis. A population-based study over 50 years. Arthritis Rheum 48:3522–3531
Nuenninghoff DM, Hunder GG, Christianson TJH et al (2003) Mortality of large-artery complication (aortic aneurysm, aortic dissection and/or large artery stenosis) in patients with giant cell arteritis. Arthritis Rheum 48:3532–3537
Parikh M, Miller NR, Lee AG et al (2006) Prevalence of a normal C-reactive protein with an elevated erythrocyte sedimentation rate in biopsy-proven giant cell arteritis. Ophthalmology 113:1842–1845
Pipitone N, Salvarani C (2008) Improving therapeutic options for patients with giant cell arteritis. Curr Opin Rheumatol 20:17–22
Pountain G, Hazleman B, Cawston TE (1998) Circulating levels of IL-1beta, IL-6 and soluble IL-2 receptor in polymyalgia rheumatica and giant cell arteritis and rheumatoid arthritis. Br J Rheumatol 37:797–798
Pountain GD, Calvin J, Hazleman BL (1994) Alpha 1-antichymotrypsin, C-reactive protein and erythrocyte sedimentation rate in polymyalgia rheumatica and giant cell arteritis. Br J Rheumatol 33:550–554
Proven A, Gabriel SE, Orces C et al (2003) Glucocorticoid therapy in giant cell arteritis: duration and adverse outcomes. Arthritis Rheum 49:703–708
Reinhold-Keller E, Zeidler A, Gutfleisch J et al (2000) Giant cell arteritis is more prevalent in urban than in rural populations: results of an epidemiological study of primary systemic vasculitides in Germany. Rheumatology 39:1396–1402
Roche NE, Fulbright JW, Wagner AD et al (1993) Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis. Arthritis Rheum 36:1286–1294
Salvarani C, Cantini F, Boiardi L et al (2003) Laboratory investigations useful in giant cell arteritis and Takayasu’s arteritis. Clin Exp Rheumatol 21:S23–S28
Salvarani C, Macchioni P, Boiardi L et al (1992) Soluble interleukin 2 receptors in polymyalgia rheumatica/giant cell arteritis. Clinical and laboratory correlations. J Rheumatol 19:1100–1106
Salvarani C, Cantini F, Boiardi L, Hunder GG (2002) Polymyalgia rheumatica and giant-cell arteritis. N Engl J Med 347:261–271
Salvarani C, Cantini F, Hunder GG (2008) Polymyalgia rheumatica and giant-cell arteritis. Lancet 372:234–245
Salvarani C, Barozzi L, Cantini F et al (2008) Cervical interspinous bursitis in active polymyalgia rheumatica. Ann Rheum Dis 67:758–761
Schmidt D, Vaith P (2005) Riesenzellarteriitis (Arteriitis cranialis, Arteriitis temporalis Horton). Dtsch Med Wochenschr 130:1877–1881
Smetana GW, Shmerling RH (2002) Does this patient have temporal arteritis? JAMA 287:92–101
Vaith P (1997) Polymyalgia rheumatica und Riesenzellarteriitis. In: Peter HH (Hrsg) Klinik der Gegenwart, Bd 4: XIV. Urban & Schwarzenberg, München Wien Baltimore, S 1–19
Vaith P, Prasauskas V, Potempa LA et al (1996) Complement activation by C-reactive protein on the HEp-2 cell substrate. Int Arch Allergy Immunol 111:107–117
KJ von, Wassatjerna C (1976) Liver involvement in polymyalgia rheumatica. Scand J Rheumatol 5:197–204
Weyand CM, Fulbright JW, Hunder GG et al (2000) Treatment of giant cell arteritis: interleukin-6 as a biologic marker of disease activity. Arthritis Rheum 43:1041–1048
Weyand CM, Goronzy JJ (2003) Medium- and large-vessel vasculitis. N Engl J Med 349:160–169
Reinhard M, Schmidt WA, Hetzel A, Bley TA (2008) Bildgebung der Riesenzellarteriitis mittels Sonographie und MRT. Z Rheumatol (DOI: s00393-008-0375-5)
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Vaith, P., Warnatz, K. Internistische und serologische Befunde der Riesenzellarteriitis. Z. Rheumatol. 68, 124–131 (2009). https://doi.org/10.1007/s00393-008-0377-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00393-008-0377-3