Abstract
Background
Patients with suspected heart failure (HF) often present first to general practitioners (GPs). Timely and accurate HF diagnosis and reliable prognostic information have remained unmet goals in primary care, where patient evaluation often relies on clinical assessment only. The Handheld-BNP program investigates whether additional use of portable echocardiography (ECHO) and point-of-care determination of B-type natriuretic peptide (BNP) improves the accuracy of HF diagnosis and aids risk prediction in primary care.
Methods and results
A research network was established between 2 academic centers, 2 × 6 cardiologists, and 2 × 24 GPs inexperienced with ECHO and BNP. The Training Study investigates the feasibility of implementing GP use and interpretation of ECHO and BNP. After training, competence is assessed using multiple-choice testing (pass mark: > 80% correct diagnoses). In the cluster-randomized four-arm Screening Study, each GP passes in random order through four study arms: clinical assessment (CA), CA + BNP, CA + ECHO, and CA + ECHO + BNP. Cardiologists’ diagnoses serve as reference. Primary endpoint is the rate of correct GP diagnoses per study arm. In the Prognostic Follow-Up Study, patients are followed up centrally for 72 months. Forty-four GPs were successfully trained. With 225 ± 34 (75 ± 3) and 233 ± 28 (81 ± 7) min, respectively, total ECHO (BNP) training times were similar between centers I and II. Furthermore, training results did not differ between centers.
Conclusions
Standardized training of limited duration enabled GPs to use ECHO and BNP for HF diagnosis. The Handheld-BNP program will provide robust evaluation of the diagnostic effectiveness and prognostic value of these tools in primary care.
Trial Registration
http://www.controlled-trials.com (ISRCTN23325295).
Similar content being viewed by others
References
Kannel WB (2000) Incidence and epidemiology of heart failure. Heart Fail Rev 5:167–173
Mosterd A, Hoes AW (2007) Clinical epidemiology of heart failure. Heart 93:1137–1146
Bleumink GS, Knetsch AM, Sturkenboom MC, Straus SM, Hofman A, Deckers JW, Witteman JC, Stricker BH (2004) Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J 25:1614–1619
Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, Isasi CR, Jimenez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Mackey RH, Matsushita K, Mozaffarian D, Mussolino ME, Nasir K, Neumar RW, Palaniappan L, Pandey DK, Thiagarajan RR, Reeves MJ, Ritchey M, Rodriguez CJ, Roth GA, Rosamond WD, Sasson C, Towfighi A, Tsao CW, Turner MB, Virani SS, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P, American Heart Association Statistics C, Stroke Statistics S (2017) Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation 135:e146–e603
Hobbs FD, Kenkre JE, Roalfe AK, Davis RC, Hare R, Davies MK (2002) Impact of heart failure and left ventricular systolic dysfunction on quality of life: a cross-sectional study comparing common chronic cardiac and medical disorders and a representative adult population. Eur Heart J 23:1867–1876
Hobbs FD, Korewicki J, Cleland JG, Eastaugh J, Freemantle N, Investigators I (2005) The diagnosis of heart failure in European primary care: the IMPROVEMENT programme survey of perception and practice. Eur J Heart Fail 7:768–779
Fuat A, Hungin AP, Murphy JJ (2003) Barriers to accurate diagnosis and effective management of heart failure in primary care: qualitative study. BMJ 326:196
Stork S, Handrock R, Jacob J, Walker J, Calado F, Lahoz R, Hupfer S, Klebs S (2017) Treatment of chronic heart failure in Germany: a retrospective database study. Clin Res Cardiol 106:923–932
Boonman-de Winter LJ, Rutten FH, Cramer MJ, Landman MJ, Liem AH, Rutten GE, Hoes AW (2012) High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes. Diabetologia 55:2154–2162
Rutten FH, Cramer MJ, Grobbee DE, Sachs AP, Kirkels JH, Lammers JW, Hoes AW (2005) Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease. Eur Heart J 26:1887–1894
Remes J, Miettinen H, Reunanen A, Pyorala K (1991) Validity of clinical diagnosis of heart failure in primary health care. Eur Heart J 12:315–321
Wright SP, Doughty RN, Pearl A, Gamble GD, Whalley GA, Walsh HJ, Gordon G, Bagg W, Oxenham H, Yandle T, Richards M, Sharpe N (2003) Plasma amino-terminal pro-brain natriuretic peptide and accuracy of heart-failure diagnosis in primary care: a randomized, controlled trial. J Am Coll Cardiol 42:1793–1800
McKee PA, Castelli WP, McNamara PM, Kannel WB (1971) The natural history of congestive heart failure: the Framingham study. N Engl J Med 285:1441–1446
Cowie MR, Struthers AD, Wood DA, Coats AJ, Thompson SG, Poole-Wilson PA, Sutton GC (1997) Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care. Lancet 350:1349–1353
Clarke KW, Gray D, Hampton JR (1994) Evidence of inadequate investigation and treatment of patients with heart failure. Br Heart J 71:584–587
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, Authors/Task Force M (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37:2129–2200
Wierzchowiecki M, Poprawski K, Nowicka A, Kandziora M, Piatkowska A (2005) Knowledge of primary care physicians, cardiologists from cardiology clinics, internal and cardiology department physicians about chronic heart failure diagnosis and treatment. Pol Merkur Lekarski 18:210–215
Yusuf S, Pitt B, Davis CE, Hood WB, Cohn JN (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325:293–302
Yusuf S, Pitt B, Davis CE, Hood WB Jr, Cohn JN (1992) Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 327:685–691
Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ Jr, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC et al (1992) Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med 327:669–677
McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Kober L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Ronnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Guidelines ESCCfP (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33:1787–1847
Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Stromberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K, Guidelines ESCCfP (2008) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 29:2388–2442
Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, Omland T, Storrow AB, Abraham WT, Wu AH, Clopton P, Steg PG, Westheim A, Knudsen CW, Perez A, Kazanegra R, Herrmann HC, McCullough PA, Breathing Not Properly Multinational Study I (2002) Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347:161–167
Mueller C, Scholer A, Laule-Kilian K, Martina B, Schindler C, Buser P, Pfisterer M, Perruchoud AP (2004) Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 350:647–654
McCullough PA, Nowak RM, McCord J, Hollander JE, Herrmann HC, Steg PG, Duc P, Westheim A, Omland T, Knudsen CW, Storrow AB, Abraham WT, Lamba S, Wu AH, Perez A, Clopton P, Krishnaswamy P, Kazanegra R, Maisel AS (2002) B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from breathing not properly (BNP) Multinational Study. Circulation 106:416–422
Burri E, Hochholzer K, Arenja N, Martin-Braschler H, Kaestner L, Gekeler H, Hatziisaak T, Buttiker M, Fraulin A, Potocki M, Breidthardt T, Reichlin T, Socrates T, Twerenbold R, Mueller C (2012) B-type natriuretic peptide in the evaluation and management of dyspnoea in primary care. J Intern Med 272:504–513
Zaphiriou A, Robb S, Murray-Thomas T, Mendez G, Fox K, McDonagh T, Hardman SM, Dargie HJ, Cowie MR (2005) The diagnostic accuracy of plasma BNP and NTproBNP in patients referred from primary care with suspected heart failure: results of the UK natriuretic peptide study. Eur J Heart Fail 7:537–541
Mogelvang R, Goetze JP, Schnohr P, Lange P, Sogaard P, Rehfeld JF, Jensen JS (2007) Discriminating between cardiac and pulmonary dysfunction in the general population with dyspnea by plasma pro-B-type natriuretic peptide. J Am Coll Cardiol 50:1694–1701
Fuat A, Murphy JJ, Hungin AP, Curry J, Mehrzad AA, Hetherington A, Johnston JI, Smellie WS, Duffy V, Cawley P (2006) The diagnostic accuracy and utility of a B-type natriuretic peptide test in a community population of patients with suspected heart failure. Br J Gen Pract 56:327–333
Collinson PO (2006) The cost effectiveness of B-Type natriuretic peptide measurement in the primary care setting-a UK perspective. Congest Heart Fail 12:103–107
Sim V, Hampton D, Phillips C, Lo SN, Vasishta S, Davies J, Penney M (2003) The use of brain natriuretic peptide as a screening test for left ventricular systolic dysfunction-cost-effectiveness in relation to open access echocardiography. Fam Pract 20:570–574
Barrios V, Llisterri JL, Escobar C, Alfaro P, Colado F, Ridocci F, Matali A (2011) Clinical applicability of B-type natriuretic peptide in patients with suspected heart failure in primary care in Spain: the PANAMA study. Expert Rev Cardiovasc Ther 9:579–585
Taylor CJ, Roalfe AK, Iles R, Hobbs FR, investigators R, Barton P, Deeks J, McCahon D, Cowie MR, Sutton G, Davis RC, Mant J, McDonagh T, Tait L (2017) Primary care REFerral for EchocaRdiogram (REFER) in heart failure: a diagnostic accuracy study. Br J Gen Pract 67:e94-e102
Kelder JC, Cramer MJ, van Wijngaarden J, van Tooren R, Mosterd A, Moons KG, Lammers JW, Cowie MR, Grobbee DE, Hoes AW (2011) The diagnostic value of physical examination and additional testing in primary care patients with suspected heart failure. Circulation 124:2865–2873
Lang NN, Wong CM, Dalzell JR, Jansz S, Leslie SJ, Gardner RS (2014) The ease of use and reproducibility of the alere heart check system: a comparison of patient and healthcare professional measurement of BNP. Biomark Med 8:791–796
Monfort A, Da Silva K, Vodovar N, Gayat E, Cohen-Solal A, Manivet P (2015) Clinical evaluation of the heart check system, a new quantitative measurement of fresh capillary BNP. Biomark Med 9:1323–1330
Olausson J, Peterson C, Bergstrom M, Larsson A (2015) Evaluation of the meritas(R) BNP test for point-of-care testing. Clin Lab 61:727–730
Di Somma S, Zampini G, Vetrone F, Soto-Ruiz KM, Magrini L, Cardelli P, Ronco C, Maisel A, Peacock FW (2014) Opinion paper on utility of point-of-care biomarkers in the emergency department pathways decision making. Clin Chem Lab Med 52:1401–1407
Iwaz JA, Maisel AS (2016) Recent advances in point-of-care testing for natriuretic peptides: potential impact on heart failure diagnosis and management. Expert Rev Mol Diagn 16:641–650
Pecoraro V, Banfi G, Germagnoli L, Trenti T (2017) A systematic evaluation of immunoassay point-of care-testing to define impact on patients outcomes. Ann Clin Biochem 54:420–431
Cals JW, Schols AM, van Weert HC, Stevens F, Zeijen CG, Holtman G, Lucassen WA, Berger MY (2014) Point-of-care testing in family practices: present use and need for tests in the future. Ned Tijdschr Geneeskd 158:A8210
Tait L, Roalfe AK, Mant J, Cowie MR, Deeks JJ, Iles R, Barton PM, Taylor CJ, Derit M, Hobbs FD (2012) The REFER (REFer for EchocaRdiogram) protocol: a prospective validation of a clinical decision rule, NT-proBNP, or their combination, in the diagnosis of heart failure in primary care. Rationale and design. BMC Cardiovasc Disord 12:97
Madamanchi C, Alhosaini H, Sumida A, Runge MS (2014) Obesity and natriuretic peptides, BNP and NT-proBNP: mechanisms and diagnostic implications for heart failure. Int J Cardiol 176:611–617
Maisel A, Mueller C, Adams K Jr, Anker SD, Aspromonte N, Cleland JG, Cohen-Solal A, Dahlstrom U, DeMaria A, Di Somma S, Filippatos GS, Fonarow GC, Jourdain P, Komajda M, Liu PP, McDonagh T, McDonald K, Mebazaa A, Nieminen MS, Peacock WF, Tubaro M, Valle R, Vanderhyden M, Yancy CW, Zannad F, Braunwald E (2008) State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail 10:824–839
Cowie MR, Jourdain P, Maisel A, Dahlstrom U, Follath F, Isnard R, Luchner A, McDonagh T, Mair J, Nieminen M, Francis G (2003) Clinical applications of B-type natriuretic peptide (BNP) testing. Eur Heart J 24:1710–1718
Smith H, Pickering RM, Struthers A, Simpson I, Mant D (2000) Biochemical diagnosis of ventricular dysfunction in elderly patients in general practice: observational study. BMJ 320:906–908
Excellence NIoHaC Chronic heart failure in adults: management. CG108. https://www.nice.org.uk/guidance/cg108/chapter/1-Guidance-diagnosing-heart-failure. Accessed 29 Sept 2017
Seraphim A, Paschou SA, Grapsa J, Nihoyannopoulos P (2016) Pocket-sized echocardiography devices: one stop shop service? J Cardiovasc Ultrasound 24:1–6
Prinz C, Voigt JU (2011) Diagnostic accuracy of a hand-held ultrasound scanner in routine patients referred for echocardiography. J Am Soc Echocardiogr 24:111–116
Stoica R, Heller EN, Bella JN (2011) Point-of-care screening for left ventricular hypertrophy and concentric geometry using hand-held cardiac ultrasound in hypertensive patients. Am J Cardiovasc Dis 1:119–125
Fukuda S, Shimada K, Kawasaki T, Fujimoto H, Maeda K, Inanami H, Yoshida K, Jissho S, Taguchi H, Yoshiyama M, Yoshikawa J (2009) Pocket-sized transthoracic echocardiography device for the measurement of cardiac chamber size and function. Circ J 73:1092–1096
Kono Y, Fukuda S, Shimada K, Oe H, Maeda K, Kawasaki T, Fujimoto H, Otsuka K, Kubo T, Jissho S, Taguchi H, Yoshiyama M, Ito H, Yoshikawa J (2011) Pocket-sized echo for evaluation of mitral and tricuspid regurgitation. JACC Cardiovasc Imaging 4:921
Bornemann P, Johnson J, Tiglao S, Moghul A, Swain S, Bornemann G, Lustik M (2015) Assessment of primary care physicians’ use of a pocket ultrasound device to measure left ventricular mass in patients with hypertension. J Am Board Fam Med 28:706–712
Spencer KT, Anderson AS, Bhargava A, Bales AC, Sorrentino M, Furlong K, Lang RM (2001) Physician-performed point-of-care echocardiography using a laptop platform compared with physical examination in the cardiovascular patient. J Am Coll Cardiol 37:2013–2018
Fedson S, Neithardt G, Thomas P, Lickerman A, Radzienda M, DeCara JM, Lang RM, Spencer KT (2003) Unsuspected clinically important findings detected with a small portable ultrasound device in patients admitted to a general medicine service. J Am Soc Echocardiogr 16:901–905
Lipczynska M, Szymanski P, Klisiewicz A, Hoffman P (2011) Hand-carried echocardiography in heart failure and heart failure risk population: a community based prospective study. J Am Soc Echocardiogr 24:125–131
Evangelista A, Galuppo V, Mendez J, Evangelista L, Arpal L, Rubio C, Vergara M, Liceran M, Lopez F, Sales C, Miralles V, Galinsoga A, Perez J, Arteaga M, Salvador B, Lopez C, Garcia-Dorado D (2016) Hand-held cardiac ultrasound screening performed by family doctors with remote expert support interpretation. Heart 102:376–382
Filipiak-Strzecka D, John B, Kasprzak JD, Michalski B, Lipiec P (2013) Pocket-size echocardiograph–a valuable tool for nonexperts or just a portable device for echocardiographers? Adv Med Sci 58:67–72
Sicari R, Galderisi M, Voigt JU, Habib G, Zamorano JL, Lancellotti P, Badano LP (2011) The use of pocket-size imaging devices: a position statement of the European Association of Echocardiography. Eur J Echocardiogr 12:85–87
Seward JB, Douglas PS, Erbel R, Kerber RE, Kronzon I, Rakowski H, Sahn LD, Sisk EJ, Tajik AJ, Wann S (2002) Hand-carried cardiac ultrasound (HCU) device: recommendations regarding new technology. A report from the Echocardiography Task Force on New Technology of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr 15:369–373
Yates J, Royse CF, Royse C, Royse AG, Canty DJ (2016) Focused cardiac ultrasound is feasible in the general practice setting and alters diagnosis and management of cardiac disease. Echo Res Pract 3:63–69
Mehrhof F, Loffler M, Gelbrich G, Ozcelik C, Posch M, Hense HW, Keil U, Scheffold T, Schunkert H, Angermann C, Ertl G, Jahns R, Pieske B, Wachter R, Edelmann F, Wollert KC, Maisch B, Pankuweit S, Erbel R, Neumann T, Herzog W, Katus H, Muller-Tasch T, Zugck C, Dungen HD, Regitz-Zagrosek V, Lehmkuhl E, Stork S, Siebert U, Wasem J, Neumann A, Gohler A, Anker SD, Kohler F, Mockel M, Osterziel KJ, Dietz R, Rauchhaus M, Competence Network Heart F (2010) A network against failing hearts—introducing the German “Competence Network Heart Failure”. Int J Cardiol 145:135–138
Cheng V, Kazanagra R, Garcia A, Lenert L, Krishnaswamy P, Gardetto N, Clopton P, Maisel A (2001) A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 37:386–391
Kannel WB, D’Agostino RB, Silbershatz H, Belanger AJ, Wilson PW, Levy D (1999) Profile for estimating risk of heart failure. Arch Intern Med 159:1197–1204
Schocken DD, Arrieta MI, Leaverton PE, Ross EA (1992) Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol 20:301–306
Wheeldon NM, MacDonald TM, Flucker CJ, McKendrick AD, McDevitt DG, Struthers AD (1993) Echocardiography in chronic heart failure in the community. Q J Med 86:17–23
Hlatky MA, Fleg JL, Hinton PC, Lakatta EG, Marcus FI, Smith TW, Strauss HC (1986) Physician practice in the management of congestive heart failure. J Am Coll Cardiol 8:966–970
Ware JE (1996) The SF-36 health survey. In: Spilker B (ed) Quality of life and pharmacoeconomics in clinical trials. Raven, Philadelphia, pp 337–346
Lowe B, Grafe K, Zipfel S, Witte S, Loerch B, Herzog W (2004) Diagnosing ICD-10 depressive episodes: superior criterion validity of the Patient Health Questionnaire. Psychother Psychosom 73:386–390
Kroenke K, Spitzer RL, Williams JB (2003) The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 41:1284–1292
Whiting P, Rutjes AW, Reitsma JB, Glas AS, Bossuyt PM, Kleijnen J (2004) Sources of variation and bias in studies of diagnostic accuracy: a systematic review. Ann Intern Med 140:189–202
Rutjes AW, Reitsma JB, Di Nisio M, Smidt N, van Rijn JC, Bossuyt PM (2006) Evidence of bias and variation in diagnostic accuracy studies. CMAJ 174:469–476
Roberts E, Ludman AJ, Dworzynski K, Al-Mohammad A, Cowie MR, McMurray JJ, Mant J, Nice Guideline Development Group for Acute Heart Failure (2015) The diagnostic accuracy of the natriuretic peptides in heart failure: systematic review and diagnostic meta-analysis in the acute care setting. BMJ 350:h910
Kelder JC, Cramer MJ, Verweij WM, Grobbee DE, Hoes AW (2011) Clinical utility of three B-type natriuretic peptide assays for the initial diagnostic assessment of new slow-onset heart failure. J Card Fail 17:729–734
Papanicolas I, Jha AK (2017) Challenges in international comparison of health care systems. JAMA 318:515–516
Acknowledgements
The authors thank all general practitioners and cardiologists contributing to the Handheld-BNP program. General practitioners receive honoraria for patient enrolment and follow-up (€200 per randomized patient for enrolment visit, completion of case report form and delivery of biomaterials, and €20 per completed of follow-up case report form). Cardiologists receive honoraria for expert patient assessment (€200 per patient for baseline heart failure diagnosis and completion of case report form). The authors also thank patients willing to participate in the Handheld-BNP program. Patients are not compensated for study participation. The authors wish to especially thank Prof. Dr. Goetz Gelbrich (Institute for Clinical Epidemiology and Biometry, University of Würzburg) for statistical advice, Monika Hanke for supervision and quality control of data collection, and Robert Wenzl for expert graphical design of the figures. The authors also thank the clinical research teams at both study centers, and the study and data managers at the Clinical Trial Center Leipzig and at the Comprehensive Heart Failure Center, Würzburg. English language editing support was provided by Nicola Ryan, BSc, independent medical writer, supported by the University of Würzburg. The Handheld-BNP program is funded in the frame of the Competence Network Heart Failure by the Federal Ministry of Education and Research (BMBF), Germany (BMBF, Grants 01GI0205 and 01GI1202A). Equipment and test kits for BNP point-of-care testing are provided by Biosite Diagnostics GmbH, Gießerallee 31, 47877 Willich (now Alere Technologies GmbH, Löbstedter Str. 103–105 07749 Jena). Ultrasound equipment is provided by Philips Medizinsysteme Ultraschall, Röntgenstr. 24, 22335 Hamburg.
Author information
Authors and Affiliations
Consortia
Corresponding author
Ethics declarations
Conflict of interest
Dr. Störk reported receiving grants from the Federal Ministry for Education and Research, Boehringer, and Santhera; grants and personal fees from Servier, Pfizer, Novartis, Roche Diagnostics, and Thermo Fisher/Brahms; and personal fees from AstraZeneca, Genzyme, Medtronic, and Bayer. Dr. Ertl reported receiving grants from the German Ministry of Education and Research; and grants and personal fees Novartis and Boehringer Ingelheim. Dr. Angermann reported receiving funding for the Handheld-BNP program in the frame of the Competence Network Heart Failure by the Federal Ministry of Education and Research (Grants 01GI0205 and 01GI1202A) and nonfinancial support of the Handheld-BNP program from Biosite Diagnostics (now Alere Technologies), Germany, and Philips Medizinsysteme Ultraschall, Germany. Outside the current project, Dr. Angermann reported grants, personal fees, nonfinancial support, and other from ResMed; grants, personal fees, and other from Novartis; grants and nonfinancial support from Thermo Fisher; grants and personal fees from Boehringer and Vifor; nonfinancial support from the University Hospital Würzburg and the Comprehensive Heart Failure Center Würzburg; and grant support from the German Ministry for Education and Research. All other authors state that they have no conflicts of interest to declare.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Morbach, C., Buck, T., Rost, C. et al. Point-of-care B-type natriuretic peptide and portable echocardiography for assessment of patients with suspected heart failure in primary care: rationale and design of the three-part Handheld-BNP program and results of the training study. Clin Res Cardiol 107, 95–107 (2018). https://doi.org/10.1007/s00392-017-1181-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00392-017-1181-3