Zusammenfassung
Wir berichten den Verlauf eines Patienten nach ‘Crush-Stenting’ von Paclitaxel-freisetzenden TAXUS-Stents innerhalb einer LAD/D1-Bifurkationsstenose. Speziell zur Evaluation der neointimalen Antwort des Hauptgefäßes auf diesen Eingriff führten wir nach 9 Monaten eine elektive Re-Angiographie mit intravaskulärer Bildgebung mittels ‘Optical Coherence Tomography (OCT)’, einer neuartigen hochauflösenden Bildgebungstechnik, und IVUS durch. Die Untersuchung zeigte, das die Stents im Hauptgefäß mit einer homogenen neointimalen Schicht überdeckt waren ohne Hinweise auf eine bedeutsame Lumeneinengung oder eine Malapposition. Im Vergleich zu IVUS bestätigte OCT die Einbettung der Stentstreben in die Gefäßwand mit einer deutlich überlegenen Darstellungsqualität und ermöglichte darüber hinaus neue Einsichten in das Stentverhalten innerhalb offener Bifurkationsstellen.
Summary
We report a case of crush-stenting with Paclitaxeleluting TAXUS stents in a left anterior descending artery (LAD) bifurcation lesion. In order to obtain precise information on the mid-term neointimal response of the main vessel to this approach, we evaluated the patient angiographically 9 months later, including intravascular visualization with optical coherence tomography (OCT), a new high resolution imaging technique, and IVUS. The evaluation revealed that there was a homogeneous neointimal coverage of the main vessel stents without evidence of significant recurrent lumen renarrowing or malappositions. Compared to IVUS, OCT proved the coverage of the stent struts adjacent to the vessel wall with a superior imaging quality and, in addition, provided new insights into the stent performance at the open bifurcation site.
References
Al Suwaidi J, Berger PB, Rihal CS, Garratt KN, Bell MR, Ting HH, Bresnahan JF, Grill DE, Holmes DR Jr (2000) Immediate and long term outcome of intracoronary stent implantation for true bifurcation lesions. J Am Coll Cardiol 35:929–936
Morice MC, Serruys PW, Sousa JE, Fajadet J, Ban Hayashi E, Perin M, Colombo A, Schuler G, Barragan P, Guagliumi G, Molnar F, Falotico R, RAVEL study group (2002) A randomized comparison of a sirolimuseluting stent with a standard stent for coronary revascularization. N Engl J Med 346:1773–1780
Colombo A, Drzewiecki J, Banning A, Grube E, Hauptmann K, Silber S, Dudek D, Fort S, Schiele F, Zmudka K, Guagliumi G, Russell ME, TAXUS II study group (2003) Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions. Circulation 108:R36–R42
Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O’Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, Jaeger JL, Kuntz RE, SIRIUS Investigators (2003) Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med 349(14):1315–1323
Stone GW, Ellis SG, Cox DA, Hermiller J, O’Shaughnessy C, Mann JT, Turco M, Caputo R, Bergin P, Greenberg J, Popma JJ, Russell ME, TAXUS-IV Investigators (2004) One-year clinical results with the slow-release, polymer-based, paclitaxel-eluting TAXUS stent: the TAXUS-IV trial. Circulation 109(16):1942–1947
Stone GW, Ellis SG, Cox DA, Hermiller J, O’Shaughnessy C, Mann JT, Turco M, Caputo R, Bergin P, Greenberg J, Popma JJ, Russell ME, TAXUS-IV Investigators (2004) A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med 350(3):221–231
Tanabe K, Hoye A, Lemos PA, Aoki J, Arampatzis CA, Saia F, Lee CH, Degertekin M, Hofma SH, Sianos G, McFadden E, Smits PC, van der Giessen WJ, de Feyter P, van Domburg RT, Serruys PW (2004) Restenosis rates following bifurcation stenting with sirolimus-eluting stents for de novo narrowings. Am J Cardiol 94(1):115–118
Colombo A, Moses JW, Morice MC, Ludwig J, Holmes DR Jr, Spanos V, Louvard Y, Desmedt B, Di Mario C, Leon MB (2004) Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions. Circulation 109(10):1244–1249
Ormiston JA, Currie E, Webster MW, Kay P, Ruygrok PN, Stewart JT, Padgett RC, Panther MJ (2004) Drugeluting stents for coronary bifurcations: insights into the crush technique. Catheter Cardiovasc Interv 63(3):332–336
Colombo A, Stankovic G, Orlic D, Corvaja N, Liistro F, Airoldi F, Chieffo A, Spanos V, Montorfano M, Di Mario C (2003) Modified T-stenting technique with crushing for bifurcation lesions: immediate results and 30-day outcome. Catheter Cardiovasc Interv 60(2):145–151
Gerckens U, Buellesfeld L, McNamara E, Grube E. Optical Coherence Tomography (OCT) (2003) Potential of a new high-resolution intracoronary imaging technique. Herz 28(6):496–500
Regar E, Schaar JA, Mont E, Virmani R, Serruys PW (2003) Optical coherence tomography. Cardiovasc Radiat Med 4(4):198–204
Bouma BE, Tearney GJ, Yabushita H, Shishkov M, Kauffman CR, DeJoseph Gauthier D, MacNeill BD, Houser SL, Aretz HT, Halpern EF, Jang IK (2003) Evaluation of intracoronary stenting by intravascular optical coherence tomography. Heart 89(3):317–320
Virmani R, Farb A, Kolodgie FD (2002) Histopathologic alterations after endovascular radiation and anti-proliferative stents: similarities and differences. Herz 27(1):1–6
Sindermann JR, Verin V, Hopewell JW, Rodemann HP, Hendry JH (2004) Biological aspects of radiation and drug-eluting stents for the prevention of restenosis. Cardiovasc Res 63(1):22–30
Grube E, Lansky A, Hauptmann KE, Di Mario C, Di Sciascio G, Colombo A, Silber S, Stumpf J, Reifart N, Fajadet J, Marzocchi A, Schofer J, Dumas P, Hoffmann R, Guagliumi G, Pitney M, Russell ME; SCORE randomized trial (2004) High-dose 7-hexanoyltaxol-eluting stent with polymer sleeves for coronary revascularization: one-year results from the SCORE randomized trial. J Am Coll Cardiol 44(7):1368–1372
McFadden EP, Stabile E, Regar E, Cheneau E, Ong AT, Kinnaird T, Suddath WO, Weissman NJ, Torguson R, Kent KM, Pichard AD, Satler LF, Waksman R, Serruys PW (2004) Late thrombosis in drug-eluting coronary stents after discontinuation of antiplatelet therapy. Lancet 364(9444):1519–1521
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Buellesfeld, L., Lim, V., Gerckens, U. et al. Comparative endoluminal visualization of TAXUS crush-stenting at 9 months follow-up by intravascular ultrasound and optical coherence tomography. ZS Kardiologie 94, 690–694 (2005). https://doi.org/10.1007/s00392-005-0276-4
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DOI: https://doi.org/10.1007/s00392-005-0276-4