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Erythrocyte rheological properties but not whole blood and plasma viscosity are associated with severity of hypertension in older people

Zusammenhang des Hypertonieschweregrads bei älteren Menschen mit den rheologischen Eigenschaften der Erythrozyten, nicht aber mit der Viskosität von Vollblut und Plasma

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Abstract

Objective

This study was carried out to determine whether changes in hemorheological parameters parallel the severity of essential hypertension.

Methods

A total of 198 older hypertensive patients were recruited and classified into 3 stages of hypertension according to the grading standard of hypertension. The whole blood viscosity (WBV) at various shear rates, plasma viscosity and erythrocyte rheology (including erythrocyte rigidity index, erythrocyte aggregation index and erythrocyte deformation index) were examined.

Results

Erythrocyte rheology paralleled the severity of essential hypertension and was significantly correlated to the average 24 h systolic blood pressure and diastolic blood pressure. Logistic analysis revealed that erythrocyte rigidity and the erythrocyte aggregation index were positively correlated with the severity of hypertension, while the erythrocyte deformation index was negatively correlated. No association was found between WBV, plasma viscosity and the severity of hypertension.

Conclusion

The rheological properties of erythrocyte viscosity were correlated with the severity of hypertension in older people but the WBV and plasma viscosity were not.

Zusammenfassung

Zielsetzung

In der vorliegenden Studie wurde untersucht, ob sich hämorheologische Störungen parallel zum Schweregrad einer essenziellen Hypertonie verändern.

Methoden

Insgesamt wurden 198 ältere Patienten mit Bluthochdruck in die Studie eingeschlossen und entsprechend der Standardeinteilung einem von 3 Hypertoniestadien zugeordnet. Untersucht wurden die Viskosität des Vollbluts bei verschiedenen Schergeschwindigkeiten, die Plasmaviskosität und die rheologischen Eigenschaften der Erythrozyten, einschließlich des Rigiditäts-, Aggregations- und Verformungsindex der Erythrozyten.

Ergebnisse

Die rheologischen Eigenschaften der Erythrozyten waren mit dem Schweregrad der essenziellen Hypertonie assoziiert und korrelierten signifikant mit dem durchschnittlichen systolischen und diastolischen Blutdruck über 24 h. Logistische Analysen ergaben, dass die Indizes der Erythrozytenrigidität und -aggregation positiv mit der Hypertonieschwere korrelierten, der Erythrozytenverformungsindex dagegen negativ. Kein Zusammenhang fand sich bezüglich der Viskosität des Vollbluts und Plasmas.

Schlussfolgerung

Die rheologischen Eigenschaften der Erythrozytenviskosität korrelierten mit dem Schweregrad der Hypertonie bei älteren Menschen, während für die Viskosität des Vollbluts und Plasmas kein solcher Zusammenhang bestand.

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References

  1. Stuart J, Kenny MW (1980) Blood rheology. J Clin Pathol 3:417–429

    Article  Google Scholar 

  2. Chien S (1977) Blood rheology in hypertension and cardiovascular disease. Cardiovasc Med 2:356–360

    Google Scholar 

  3. Yapislar H, Taskin E (2014) L‑carnosine alters some hemorheologic and lipid peroxidation parameters in nephrectomized rats. Med Sci Monit 11(20):399–405

    Google Scholar 

  4. Bhavsar J, Rosenson RS (2010) Adenosine transport, erythrocyte deformability and microvascular dysfunction: an unrecognized potential role for dipyridamole therapy. Clin Hemorheol Microcirc 44:193–205

    CAS  PubMed  Google Scholar 

  5. Jae SY, Kurl S, Laukkanen JA et al (2014) Higher blood hematocrit predicts hypertension in men. J Hypertens 32:245–250

    Article  CAS  PubMed  Google Scholar 

  6. Letcher RL, Chien S, Pickering TG, Sealey JE, Laragh JH (1981) Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects. Role of fibrinogen and concentration. Am J Med 70:1195–1202

    Article  CAS  PubMed  Google Scholar 

  7. Fowkes FG, Lowe GD, Rumley A, Lennie SE, Smith FB, Donnan PT (1993) The relationship between blood viscosity and blood pressure in a random sample of the population aged 55 to 74 years. Eur Heart J 14:597–601

    Article  CAS  PubMed  Google Scholar 

  8. Carallo C, Irace C, De Franceschi MS et al (2011) The effect of aging on blood plasma viscosity. An 11.6 years follow-up study. Clin Hemorheol Microcirc 47:67–74

    CAS  PubMed  Google Scholar 

  9. Pickering TG, Hall JE, Appel LJ et al (2005) Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45:142–161

    Article  CAS  PubMed  Google Scholar 

  10. Baskurt OK, Boynard M, Cokelet GC et al (2009) New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc 42:75–97

    PubMed  Google Scholar 

  11. Jones JG, Adams RA, Evans SA (1994) Bulk filtration through micropore membranes for analysing blood cell rheology in clinical research. Clin Hemorheol 14:149–169

    Google Scholar 

  12. Reid HL, Barnes AJ, Lock PJ, Dormandy JA, Dormandy TL (1976) A sample method for measuring erythrocyte deformability. J Clin Pathol 29:855–858

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. International Committee for Standardization in Haematology (1986) Expert panel on blood rheology. Clin Hemorheol 6:439–452

    Google Scholar 

  14. Bertoluzzo SM, Bollini A, Rasia M, Raynal A (1999) Kinetic model for erythrocyte aggregation. Blood Cells Mol Dis 25:338–348

    Article  Google Scholar 

  15. Tomita M, Gotoh F, Tanahashi N, Turcani P (1986) Whole blood red blood cell aggregometer for human and feline blood. Am J Physiol 251:H1205–H1210

    CAS  PubMed  Google Scholar 

  16. Brooks DE, Greig RG, Janzen J (1980) Mechanisms of erythrocyte aggregation. In: Erythrocyte mechanics and blood flow. Alan R. Liss Inc., New York, pp 119–140

    Google Scholar 

  17. White WB, Berson AS, Robbins C et al (1993) National standard for measurement of resting and ambulatory blood pressures with automated sphygmomanometers. Hypertension 21:504–509

    Article  CAS  PubMed  Google Scholar 

  18. Hinshaw LB (1996) Sepsis/septic shock: participation of the microcirculation: an abbreviated review. Crit Care Med 2:1072–1078

    Article  Google Scholar 

  19. Ajmani RS (1997) Hypertension and hemorheology. Clin Hemorheol Microcirc 17:397–420

    CAS  PubMed  Google Scholar 

  20. Shabanov VA, Terekhina EV, Kostrov VA (2001) Changes in blood rheological properties in patients with hypertension. Ter Arkh 73:70–73

    CAS  PubMed  Google Scholar 

  21. Janvier F, Zhu JX, Armstrong J, Meiselman HJ, Cloutier G (2013) Effects of amphiphilic star-shaped poly (ethylene glycol) polymers with a cholic acid core on human red blood cellaggregation. J Mech Behav Biomed Mater 18:100–107

    Article  CAS  PubMed  Google Scholar 

  22. Chabanel A, Zuccarelli F, Samama MM (1995) Red cell aggregability increases with the severity of venous insufficiency. Int Angiol 14:69–73

    CAS  PubMed  Google Scholar 

  23. Luquita A, Urli L, Svetaz MJ et al (2010) In vitro and ex vivo effect of hyaluronic acid on erythrocyte flow properties. J Biomed Sci 17:8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Michalska-Małecka K, Słowińska-Łożyńska L (2012) Aggregation and deformability of erythrocytes in primary open-angle glaucoma (POAG); the assessment of arterialhypertension. Clin Hemorheol Microcirc 51:277–285

    PubMed  Google Scholar 

  25. Salazar VBY, Martini J, Chávez NA et al (2010) Intaglietta M. Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: experimental and clinical evidence. Clin Hemorheol Microcirc 44:75–85

    Google Scholar 

  26. Salazar Vázquez BY, Salazar Vázquez MA, Intaglietta M, De Faire U, Fagrell B, Cabrales P (2009) Hematocrit and mean arterial blood pressure in pre- and postmenopause women. Vasc Health Risk Manag 5:483–488

    Google Scholar 

  27. Alkuraishy HM, Al-Gareeb AI, Albuhadilly AK (2014) Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders – a randomized controlled clinical study. Biomed Res Int 2014:324–307

    Article  Google Scholar 

  28. Baskurt OK, Meiselman HJ (1997) Cellular determinants of low-shear blood viscosity. Biorheology 34:235–247

    Article  CAS  PubMed  Google Scholar 

  29. Takiwaki M, Tomoda F, Koike T et al (2014) Increased levels of small dense low-density lipoprotein cholesterol associated with hemorheological abnormalities in untreated, early-stage essential hypertensives. Hypertens Res 37:1008–1013

    Article  CAS  PubMed  Google Scholar 

  30. Danesh J, Whincup P, Walker M, Lennon L, Thomson A, Appleby P, Rumley A, Lowe GDO (2001) Fibrin D‑dimer and coronary heart disease: prospective study and meta-analysis. Circulation 103:2323–2327

    Article  CAS  PubMed  Google Scholar 

  31. Lowe GDO, Rumley A (1999) Use of fibrinogen and fibrin-dimer in prediction of arterial thrombotic events. Thromb Haemost 82:667–672

    CAS  PubMed  Google Scholar 

  32. Kario K, Matsuo T, Kobayashi H, Yamamoto K, Shimada K (1997) Earthquake-induced potentiation of acute risk factors in hypertensive elderly patients: possible triggering of cardiovascular events after a major earthquake. J Am Coll Cardiol 29:926–933

    Article  CAS  PubMed  Google Scholar 

  33. Soma P, Pretorius E (2015) Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus. Cardiovasc Diabetol 31(14):96

    Article  Google Scholar 

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Acknowledgement

This study was supported by the National Natural Science Fund (No: 81401158).

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Authors and Affiliations

  1. Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yi Shan Road, 200233, Shanghai, People’s Republic of China

    Guo-xiang Fu, Min Ji, Li-zhi Han, Chan-chan Xu, Feng-feng Pan, Ting-jun Hu & Yuan Zhong

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  1. Guo-xiang Fu
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  2. Min Ji
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  3. Li-zhi Han
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  4. Chan-chan Xu
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  5. Feng-feng Pan
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  7. Yuan Zhong
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Corresponding author

Correspondence to Yuan Zhong.

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Conflict of interest

G-x. Fu, M. Ji, L‑z. Han, C‑c. Xu, F‑f. Pan, T-j. Hu and Y. Zhong state that there are no conflicts of interest.

All patients enrolled in this study were fully informed about the purpose and procedures and gave written informed consent. The protocol of the study was approved by the ethics committee of the institutions involved.

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Fu, Gx., Ji, M., Han, Lz. et al. Erythrocyte rheological properties but not whole blood and plasma viscosity are associated with severity of hypertension in older people. Z Gerontol Geriat 50, 233–238 (2017). https://doi.org/10.1007/s00391-016-1039-8

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  • DOI: https://doi.org/10.1007/s00391-016-1039-8

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