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Mid- and low-rectal cancer: laparoscopic vs open treatment—short- and long-term results. Meta-analysis of randomized controlled trials

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Abstract

Background

The laparoscopic approach in the treatment of mid- or low-rectal cancer is still controversial. Compared with open surgery, laparoscopic resection of extraperitoneal cancer is associated with improved short-time non-oncological outcomes, although high-level evidence showing similar short- and long-term oncological outcomes is scarce.

Objective

The aim of our paper is to study the oncological and non-oncological outcomes of laparoscopic versus open surgery for extraperitoneal rectal cancer.

Data sources

A systematic review of MedLine, EMBASE, and CENTRAL from January 1990 to October 2020 was performed by combining various key words.

Study selection

Only randomized controlled trials (RCTs) comparing laparoscopic versus open surgery for extraperitoneal rectal cancer were included. The quality of RCTs was assessed using the Cochrane reviewer’s handbook. This meta-analysis was based on the recommendation of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.

Intervention(s)

This study analyzes laparoscopic versus open surgery for extraperitoneal rectal cancer.

Main outcome measures

Primary outcomes were oncological parameters.

Results

Fifteen RCTs comprising 4,411 patients matched the selection criteria. Meta-analysis showed a significant difference between laparoscopic and open surgery in short-time non-oncological outcomes. Although laparoscopic approach increased operation time, it decreases significantly the blood loss and length of hospital stay. No significant difference was noted regarding short- and long-term oncological outcomes, but 4 and 5 years disease-free survival were statistically higher in the open group.

Limitations

There are still questions about the long-term oncological outcomes of laparoscopic surgery for extraperitoneal rectal cancer being comparable to the open technique.

Conclusions

Considering that all surgical resections have been performed in high volume centers by expert surgeons, the minimally invasive surgery in patients with extraperitoneal cancer could still be not considered equivalent to open surgery in terms of oncological radicality.

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Authors and Affiliations

  1. Department of Biotechnological and Applied Clinical Science, General Surgery, University of L’Aquila, San Salvatore Hospital, Coppito (AQ), 67100, L’Aquila, Italy

    Mario Schietroma, Lucia Romano, Adriana Ionelia Apostol, Silvia Vada, Francesco Carlei & Antonio Giuliani

  2. Epidemiology Unit, Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

    Stefano Necozione

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Schietroma, M., Romano, L., Apostol, A.I. et al. Mid- and low-rectal cancer: laparoscopic vs open treatment—short- and long-term results. Meta-analysis of randomized controlled trials. Int J Colorectal Dis 37, 71–99 (2022). https://doi.org/10.1007/s00384-021-04048-9

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