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Impact of naturopathy, yoga, and dietary interventions as adjuvant chemotherapy in the management of stage II and III adenocarcinoma of the colon

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Abstract

Introduction

Naturopathy, Yoga and Dietary interventions are known to improve the quality of life in cancer patients. We aim to evaluate the effect of naturopathy interventions along with adjuvant chemotherapy in patients who underwent surgery for Adenocarcinoma of the Colon.

Methods

A total of 116 adult patients were randomised in to one of the two groups; the experimental group received naturopathy, Yoga and Dietary interventions and the control group received psycho-social counselling in addition to standard chemotherapy. Haematological, biochemical and psychological evaluations were performed at set intervals during a total period of eighteen months starting from the first cycle of adjuvant chemotherapy.

Results

Results showed that the overall hemoglobin (p < 0.0001) and carcinoembryonic antigen (CEA) (p = 0.0038) levels were statistically significant in patients on the experimental arm. The rest of the laboratory parameters, viz. total leukocyte count, platelet counts, and serum creatinine levels, for overall data was not statistically significant in both the groups. Psychological attributes such as anxiety, depression, symptom severity, and Functional Living Index: Cancer (FLIC) were found to be statistically significant (p < 0.0001) in the experimental subjects as compared with those in the control. On the whole, men benefited more than women from the study interventions.

Conclusions

We conclude that Yoga and Naturopathy interventions in addition to chemotherapy show improvement in overall functional life index along with improvement in haemoglobin in patients with stages II and III Adenocarcinoma of Colon.

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References

  1. Boyle P, Bmj ML-, 2000 Undefined ABC of colorectal cancer: Epidemiology. bmj.com

  2. Janout V, Kollárová H (2001) Epidemiology of colorectal cancer. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 145:5–10. https://doi.org/10.5507/bp.2001.001

    Article  CAS  PubMed  Google Scholar 

  3. Ma B, Gao P, Wang H, Xu Q, Song Y, Huang X, Sun J, Zhao J, Luo J, Sun Y, Wang Z (2017) What has preoperative radio(chemo)therapy brought to localized rectal cancer patients in terms of perioperative and long-term outcomes over the past decades? A systematic review and meta-analysis based on 41,121 patients. Int J Cancer 141:1052–1065. https://doi.org/10.1002/ijc.30805

    Article  CAS  PubMed  Google Scholar 

  4. Watanabe T, Muro K, Ajioka Y et al (2018) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer. Int J Clin Oncol 23:1–34. https://doi.org/10.1007/s10147-017-1101-6

    Article  PubMed  Google Scholar 

  5. Raymond E, Faivre S, Woynarowski JM, Chaney SG (1998) Oxaliplatin: mechanism of action and antineoplastic activity. Semin Oncol 25:4–12

    CAS  PubMed  Google Scholar 

  6. Alotaibi A, Baumgartner A, Najafzadeh M, Cemeli E., Anderson D. (2012) In vitro investigation of DNA damage induced by the DNA cross-linking agents oxaliplatin and satraplatin in lymphocytes of colorectal cancer patients. J Cancer Ther 03:78–89. https://doi.org/10.4236/jct.2012.31011

  7. Comella P (2007) A review of the role of capecitabine in the treatment of colorectal cancer. Ther Clin Risk Manag 3:421–431

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Twelves C, Wong A, Nowacki MP, Abt M, Burris H III, Carrato A, Cassidy J, Cervantes A, Fagerberg J, Georgoulias V, Husseini F, Jodrell D, Koralewski P, Kröning H, Maroun J, Marschner N, McKendrick J, Pawlicki M, Rosso R, Schüller J, Seitz JF, Stabuc B, Tujakowski J, van Hazel G, Zaluski J, Scheithauer W (2005) Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med 352:2696–2704. https://doi.org/10.1056/NEJMoa043116

    Article  CAS  PubMed  Google Scholar 

  9. Sá Lilian A, Vettori Josiane C, Moreira Cláudia LR, Leandro Miraya S, Tirapelli Daniela PC, Perdoná Gleici SC, Souza Hayala CC, Oliveira Harley F, Santos Fabiana N, Rapatoni Liane, Ribeiro Karen B, Almeida Thiago CL, Feres Omar, Rocha José JRR, Peria Fernanda M (2015) Fatigue in patients with colorectal cancer treated with capecitabine and oxaliplatin. Integr Cancer Sci Ther 2. https://doi.org/10.15761/ICST.1000115

  10. Bower JE (2014) Cancer-related fatigue--mechanisms, risk factors, and treatments. Nat Rev Clin Oncol 11:597–609

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Othayoth R, Mathi P, Bheemanapally K, Kakarla L, Botlagunta M (2015) Characterization of vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. J Microencapsul 32:578–588. https://doi.org/10.3109/02652048.2015.1065921

    Article  CAS  PubMed  Google Scholar 

  12. Robien K, Oppeneer SJ, Kelly JA, Hamilton-Reeves JM (2013) Drug-vitamin D interactions: a systematic review of the literature. Nutr Clin Pract 28:194–208

    Article  PubMed  PubMed Central  Google Scholar 

  13. Toxqui L, Vaquero MP (2015) Chronic iron deficiency as an emerging risk factor for osteoporosis: a hypothesis. Nutrients 7:2324–2344

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Bourke L, Thompson G, Gibson DJ, Daley A, Crank H, Adam I, Shorthouse A, Saxton J (2011) Pragmatic lifestyle intervention in patients recovering from colon cancer: a randomized controlled pilot study. Arch Phys Med Rehabil 92:749–755. https://doi.org/10.1016/j.apmr.2010.12.020

    Article  PubMed  Google Scholar 

  15. Raghunath K, Sumathi C, Rajappa SJ (2019) Efficacy of yoga and naturopathy as an adjuvant in the management of non-Hodgkin’s lymphoma. 9:

  16. Botlagunta M (2016) Nutraceuticals-loaded chitosan nanoparticles for chemoprevention and cancer fatigue. In: Nutraceuticals. Elsevier, pp. 783–839

  17. Kim SE, Paik HY, Yoon H, Lee JE, Kim N, Sung MK (2015) Sex- and gender-specific disparities in colorectal cancer risk. World J Gastroenterol 21:5167–5175. https://doi.org/10.3748/wjg.v21.i17.5167

    Article  PubMed  PubMed Central  Google Scholar 

  18. Stein KD, Denniston M, Baker F, Dent M, Hann DM, Bushhouse S, West M (2003) Validation of a modified Rotterdam Symptom Checklist for use with cancer patients in the United States. J Pain Symptom Manag 26:975–989. https://doi.org/10.1016/S0885-3924(03)00321-X

    Article  Google Scholar 

  19. Schipper H, Clinch J, McMurray A, Levitt M (1984) Measuring the quality of life of cancer patients: the functional living index-cancer: development and validation. J Clin Oncol 2:472–483. https://doi.org/10.1200/JCO.1984.2.5.472

    Article  CAS  PubMed  Google Scholar 

  20. Sadja J, Mills PJ (2013) Effects of yoga interventions on fatigue in cancer patients and survivors: a systematic review of randomized controlled trials. Explor J Sci Heal 9:232–243

    Google Scholar 

  21. Ratnakumari ME, Manavalan N, Sathyanath D, et al Study to evaluate the changes in polycystic ovarian morphology after naturopathic and yogic interventions. Int J Yoga 11:139–147. https://doi.org/10.4103/ijoy.IJOY_62_16

  22. Fleming SA, Gutknecht NC (2010) Naturopathy and the primary care practice. Prim Care - Clin Off Pract 37:119–136

    Article  Google Scholar 

  23. Yüce S, Şeker MM, Koç S et al (2014) Oxaliplatin and ototoxicity: is it really safe for hearing? Turkish J Med Sci 44:586–589. https://doi.org/10.3906/sag-1304-76

    Article  CAS  Google Scholar 

  24. Mellios T, Ko HL, Beuth J (2010) Impact of adjuvant chemo- and radiotherapy on the cellular immune system of breast cancer patients. In Vivo (Brooklyn) 24:227–230

    Google Scholar 

  25. Nirmagustina DE, Yang Y, Kumrungsee T et al (2018) Gender difference and dietary supplemental vitamin B6: impact on colon luminal environment. J Nutr Sci Vitaminol (Tokyo) 64:116–128. https://doi.org/10.3177/jnsv.64.116

    Article  CAS  Google Scholar 

  26. Desch CE, Benson AB, Somerfield MR et al (2005) Colorectal cancer surveillance: 2005 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol 23:8512–8519. https://doi.org/10.1200/JCO.2005.04.0063

    Article  PubMed  Google Scholar 

  27. Effect of comprehensive nursing intervention on therapy and life quality of patients with breast cancer | Abstract. https://www.alliedacademies.org/abstract/effect-of-comprehensive-nursing-intervention-on-therapy-and-life-quality-of-patients-with-breast-cancer-8979.html. Accessed 5 May 2020

  28. Ko IG, Park EM, Choi HJ, Yoo J, Lee JK, Jee YS (2014) Proper exercise decreases plasma carcinoembryonic antigen levels with the improvement of body condition in elderly women. Tohoku J Exp Med 233:17–23. https://doi.org/10.1620/tjem.233.17

    Article  CAS  PubMed  Google Scholar 

  29. De Cicco P, Catani MV, Gasperi V, et al (2019) Nutrition and breast cancer: a literature review on prevention, treatment and recurrence. Nutrients

    Google Scholar 

  30. Rao RM, Raghuram N, Nagendra HR, Kodaganur GS, Bilimagga RS, Shashidhara HP, Diwakar RB, Patil S, Rao N (2017) Effects of a yoga program on mood states, quality of life, and toxicity in breast cancer patients receiving conventional treatment: a randomized controlled trial. Indian J Palliat Care 23:237–246. https://doi.org/10.4103/IJPC.IJPC_92_17

    Article  PubMed  PubMed Central  Google Scholar 

  31. Chaoul A, Milbury K, Sood AK, Prinsloo S, Cohen L (2014) Mind-body practices in cancer care. Curr Oncol Rep 16:417

    Article  PubMed  PubMed Central  Google Scholar 

  32. Distasio SA (2008) Integrating yoga in to cancer care. Clin J Oncol Nurs 12:125–130. https://doi.org/10.1188/08.CJON.125-130

    Article  PubMed  Google Scholar 

  33. Dhruva A, Miaskowski C, Abrams D, Acree M, Cooper B, Goodman S, Hecht FM (2012) Yoga breathing for cancer chemotherapy-associated symptoms and quality of life: results of a pilot randomized controlled trial. J Altern Complement Med 18:473–479. https://doi.org/10.1089/acm.2011.0555

    Article  PubMed  PubMed Central  Google Scholar 

  34. Mooventhan A, Nivethitha L (2014) Scientific evidence-based effects of hydrotherapy on various systems of the body. N Am J Med Sci 6:199–209

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

The study was undertaken by Dr. K. Kalpana Raghunath, Principal Investigator, with the support of the grant In-aid sanctioned to “Addlife Naturopathy Department” part of Basavatarakam Indo-American Cancer Hospital and Research Institute under EMR scheme of Ministry of AYUSH.

Funding

This work is supported by a grant from The Ministry of Ayurveda, Yoga & Naturopathy, Unani, Siddha, Sowa Rigpa and Homeopathy (AYUSH).

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Correspondence to Kalpana Raghunath or Mahendran Botlagunta.

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Raghunath, K., Sumathi, C., Rajappa, S.J. et al. Impact of naturopathy, yoga, and dietary interventions as adjuvant chemotherapy in the management of stage II and III adenocarcinoma of the colon. Int J Colorectal Dis 35, 2309–2322 (2020). https://doi.org/10.1007/s00384-020-03711-x

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