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Improved perioperative care is associated with improved long-term survival in colorectal cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

To compare perioperative colorectal cancer care and survival in patient cohorts operated in 2005 and in 2010 in Lithuania.

Methods

Comparative observational cohort study was performed. The study was conducted in the three Lithuanian cancer hospitals. Patients, who underwent curative surgery for colorectal cancer in 2005 and 2010, were included. Demographic characteristics, distribution of the tumors, preoperative diagnostics and staging, surgical treatment, the quality of pathological examination, morbidity, and mortality were analyzed. One- and 5-year overall survival data were compared between the groups.

Results

Colorectal cancer diagnostics and treatment improved from 2005 to 2010 significantly. The disease was identified as stage III–IV for 45 vs. 48% of the patients; however, computed tomography staging scan was performed only for 5.9 vs. 17.8% in 2005 and 2010, respectively. Laparoscopic operations were performed 1.5 vs. 10.5% and abdominoperineal resections—42.7 vs. 31.7% in 2005 and 2010, respectively. The number of harvested lymph nodes was mentioned in 55.8 vs. 97.7% of the cases, whereas more than 12 lymph nodes were examined in 18 vs. 66.6% of cases after histological examination. The overall 5-year survival was 52.1 vs. 63.1% (p < 0.0001), while the 5-year survival of the patients with stage IV of disease was 4.2 vs. 17.8% in 2005 and 2010, respectively.

Conclusion

Preoperative investigation, surgical treatment, pathological examination, and postoperative course are associated with improved overall survival in colorectal cancer patients, undergoing curative surgery in the resource-limited settings.

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Authors and Affiliations

  1. Institute of Clinical Medicine, Clinic of Gastroenterology, Nephrourology and Surgery, Vilnius University, Vilnius, Lithuania

    Eligijus Poskus, Marius Kryzauskas, Tomas Poskus, Saulius Mikalauskas & Kestutis Strupas

  2. Department of Surgery, Klaipeda University Hospital, 41 Liepojos Str, LT-92288, Klaipeda, Lithuania

    Narimantas Evaldas Samalavicius & Oleg Aliosin

  3. Department of Abdominal and General Surgery and Oncology, National Cancer Institute, Clinic of Internal, Family Medicine and Oncology, Faculty of Medicine, Vilnius University, 1 Santariskiu Str, LT-08406, Vilnius, Lithuania

    Narimantas Evaldas Samalavicius & Sarunas Dailidenas

  4. Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania

    Algimantas Tamelis, Zilvinas Saladzinskas & Paulius Lizdenis

  5. Centre of Bioinformatics and Biostatistics, Department of Human and Medical Genetics, Vilnius University, Vilnius, Lithuania

    Audrone Jakaitiene

  6. Laboratory of Cancer Epidemiology, National Cancer Institute, Vilnius, Lithuania

    Giedre Smailyte

Authors
  1. Eligijus Poskus
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  2. Marius Kryzauskas
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  3. Tomas Poskus
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  4. Saulius Mikalauskas
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  8. Algimantas Tamelis
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  9. Zilvinas Saladzinskas
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Corresponding author

Correspondence to Marius Kryzauskas.

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Poskus, E., Kryzauskas, M., Poskus, T. et al. Improved perioperative care is associated with improved long-term survival in colorectal cancer. Int J Colorectal Dis 33, 779–785 (2018). https://doi.org/10.1007/s00384-018-3021-y

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  • DOI: https://doi.org/10.1007/s00384-018-3021-y

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