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PTGER4 modulating variants in Crohn’s disease

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

Variants modulating expression of the prostaglandin receptor 4 (PTGER4) have been reported to be associated with Cohn’s disease (CD), but the clinical impact remains to be elucidated. We analyzed these variants in a large German inflammatory bowel disease (IBD) cohort and searched for a potential phenotype association.

Methods

The variants rs4495224 and rs7720838 were studied in adult German IBD patients (CD, n = 475; ulcerative colitis (UC), n = 293) and healthy controls (HC, n = 467). Data were correlated to results from NOD2 genotyping and to clinical characteristics.

Results

We found a significant association for the rs7720838 variant with overrepresentation of the T allele to CD (p = 0.0058; OR 0.7703, 95 % CI 0.641–0.926) but not to UC. Furthermore, logistic regression analysis revealed that the presence of the T allele was associated with stricturing disease behavior in CD patients (p = 0.03; OR 1.84, 95 % CI 1.07–3.16). Interestingly, the chance for developing stricturing disease behavior was enhanced if mutant alleles in both rs7720838 and NOD2 were present (OR 2.87, 95 % CI 1.42–5.81; p = 0.003). No overall association to CD or UC was found for the rs4495224 variant.

Conclusions

The PTGER4 modulating variant rs7720838 increases susceptibility for CD and might resemble a risk factor for stricturing disease behavior.

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Acknowledgments

We thank Mrs. Bettina Bochow and Mrs. Sabina Naranjo-Kuchta for technical assistance with genotyping.

Conflict of interest

The study was supported by a grant from the Eli and Edythe Broad Foundation (to C.B., Proposal No. IBD-0164R) and by the Forschungsförderung of the Charité, Universitätsmedizin Berlin.

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Authors and Affiliations

  1. Department of Hepatology and Gastroenterology, Universitätsmedizin Berlin, Charité Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany

    Matthias Prager, Janine Büttner & Carsten Büning

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  1. Matthias Prager
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  2. Janine Büttner
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  3. Carsten Büning
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Correspondence to Carsten Büning.

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Prager, M., Büttner, J. & Büning, C. PTGER4 modulating variants in Crohn’s disease. Int J Colorectal Dis 29, 909–915 (2014). https://doi.org/10.1007/s00384-014-1881-3

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