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Neuroprotective effect of neurotropin on chronic oxaliplatin-induced neurotoxicity in stage II and stage III colorectal cancer patients: results from a prospective, randomised, single-centre, pilot clinical trial

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background

Oxaliplatin is effective in adjuvant and first-line colorectal cancer chemotherapy. Oxaliplatin-induced severe chronic neurotoxicity is the main dose-limiting adverse event. No standard treatment for oxaliplatin-induced chronic neurotoxicity has been identified.

Materials and methods

We conducted a prospective pilot clinical trial to explore whether neurotropin has neuroprotective effects on chronic neurotoxicity. From May 1, 2010 to May 1, 2011, 80 stage II and III colorectal cancer patients who were eligible to receive oxaliplatin-based chemotherapy voluntarily enrolled in the trial. The patients were randomly divided into two groups, one of which received neurotropin treatment.

Results

The patients in the control group experienced significantly ≥ grade 2 and ≥ grade 3 neurotoxicity (by NCI CTCAE grading) than those in the neurotropin group (60.9 vs. 21.1 %, for at least grade 2 neurotoxicity, P = 0.001; 39 vs. 2.7 %, for at least grade 3 neurotoxicity, P < 0.001). If neurotoxicity was assessed by oxaliplatin-specific neurotoxicity grading, the patients in the control group also experienced significantly more ≥ grade 2 neurotoxicity (51.2 vs. 12.5 %, P = 0.001). Neurotropin was the only factor that affected the incidence of ≥ grade 2 neurotoxicity in the multivariate Cox proportional hazards regression analysis.

Conclusion

Neurotropin combined with oxaliplatin decreases chronic neurotoxicity effectively and safely.

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Acknowlegments

We are grateful to Dr. Zhi-Heng Peng and Dr. Wen-Hua Fan for collecting data. This study was supported by the Chinese Society of Clinical Oncology Research Funding.

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Authors and Affiliations

  1. Department of Colorectal Surgery, Sun Yat-sen University Cancer Centre, Guangzhou, Guangdong, 510060, People’s Republic of China

    R. X. Zhang, Z. H. Lu, D. S. Wan, X. J. Wu, P. R. Ding, L. H. Kong, Z. Z. Pan & G. Chen

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  1. R. X. Zhang
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  2. Z. H. Lu
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  3. D. S. Wan
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  4. X. J. Wu
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  5. P. R. Ding
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  6. L. H. Kong
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  7. Z. Z. Pan
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  8. G. Chen
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Corresponding authors

Correspondence to Z. Z. Pan or G. Chen.

Additional information

R. X. Zhang and Z. H. Lu contributed equally to this work.

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Zhang, R.X., Lu, Z.H., Wan, D.S. et al. Neuroprotective effect of neurotropin on chronic oxaliplatin-induced neurotoxicity in stage II and stage III colorectal cancer patients: results from a prospective, randomised, single-centre, pilot clinical trial. Int J Colorectal Dis 27, 1645–1650 (2012). https://doi.org/10.1007/s00384-012-1509-4

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  • DOI: https://doi.org/10.1007/s00384-012-1509-4

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