Abstract
Introduction
8-Oxoguanine DNA glycosylase 1 (OGG1), a key protein involved in the base excision repair pathway, can recognize and excise several lesions from oligodeoxynucleotides with single DNA damage. A C/G polymorphism at 1,245 bp (C1245G) in exon 7 of the OGG1 (Ser326Cys, rs1052133) is found to have a lower enzymatic activity. A variety of case–control studies have been published evaluating the association between OGG1 Ser326Cys polymorphism and colorectal cancer (CRC), though their conclusions were always contradictory.
Materials and methods
This meta-analysis enrolled 12 studies to estimate the overall risk of OGG1 Ser326Cys polymorphism associated with CRC. The pooled odds ratios (ORs) were performed for codominant model (Cys/Cys versus Ser/Ser; Ser/Cys versus Ser/Ser), dominant model (Ser/Cys + Cys/Cys versus Ser/Ser) and recessive model (Cys/Cys versus Ser/Cys + Ser/Ser).
Results
No significant associations were found for Cys/Cys versus Ser/Ser (OR = 1.19, 95% confidence interval (CI) 0.92–1.53), Ser/Cys versus Ser/Ser (OR = 1.04, 95% CI 0.95–1.13), Ser/Cys + Cys/Cys versus Ser/Ser (OR = 1.06, 95% CI 0.98–1.16) and Cys/Cys versus Ser/Cys + Ser/Ser (OR = 1.11, 95% CI 0.90–1.38); moreover, in the stratified analyses, no significantly increased risk was found for all genetic models.
Conclusions
Our meta-analysis suggests that the OGG1 Ser326Cys polymorphism is not associated with CRC risk.
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Acknowledgments
This project was supported by a grant from the Social Development Technology Projects of Kunshan City, China (KS1013) and a grant from The Technology Development Program of Nanjing Medical University, Jiangsu Province, China (08NMUM107).
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Ying Zhang and Bang-Shun He contributed equally to this work and should be considered as co-first authors.
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Zhang, Y., He, BS., Pan, YQ. et al. Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis. Int J Colorectal Dis 26, 1525–1530 (2011). https://doi.org/10.1007/s00384-011-1258-9
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DOI: https://doi.org/10.1007/s00384-011-1258-9