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Effectiveness of indocyanine green fluorescence imaging in resection of hepatoblastoma

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Abstract

Objective

The present research aimed to analyze the application of indocyanine green (ICG) fluorescence contrast technique in the resection of hepatoblastoma (HB) in children, and to discuss the use of ICG in the surgery of HB and the value of guidance.

Methods

We retrospectively analyzed the data of 23 children with HB resected using ICG fluorescence contrast technique at the Children’s Hospital of Nanjing Medical University from June 2020 to September 2022, including 16 boys and 7 girls, aged 5 days to 80 months. The patients were administered with an ICG injection of 0.1 mg/kg around 24–48 h before surgery. The surgical margin was detected by real-time fluorescence imaging and confirmed by postoperative pathology.

Results

All primary lesions showed bright fluorescence in 23 HB cases. 22 had clear borders with normal liver tissue, while one neonatal case showed no difference between tumor and background. 13 anatomic resection and 10 non-anatomic resection were performed with ICG fluorescence navigation. The surface of the residual liver was scattered with multiple tumor fluorescence, which was then locally enucleated according to the fluorescence. 22 isolated specimens were dissected and fluorescently visualized. Pathology identified deformed, vacuolated and densely arranged hepatocytes resembling pseudo-envelope changes without tumor residual, due to the compression of the tissue at the site of circumferential imaging.

Conclusion

The ring ICG fluorescence imaging of HB indicates the tumor resection boundary effectively, especially in multiple lesions cases.

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Data availability

The datasets for this article are not publicly available due to concerns regarding participant/patient anonymity. Requests to access the datasets should be directed to the corresponding author.

Abbreviations

ICG:

Indocyanine green

HB:

Hepatoblastoma

NIR:

Near-infrared

AFP:

Alpha-fetoprotein

CT:

Computed tomography

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Authors and Affiliations

  1. Department of Pediatric Surgery, Children’s Hospital of Nanjing Medical University, No.72 Guangzhou Road, Nanjing, 210000, Jiangsu, China

    Qiyang Shen, Sirui Pan, Tao Li & Jianfeng Zhou

  2. Department of Pediatric Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, China

    Xingyu Liu

Authors
  1. Qiyang Shen
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  2. Xingyu Liu
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  3. Sirui Pan
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  4. Tao Li
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  5. Jianfeng Zhou
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Contributions

Study conception and design: JZ, TL,QS, Data acquisition: QS, JZ Analysis and data interpretation: QS, JZ, Drafting of the manuscript: QS, JZ Critical revision: TL, JZ.

Corresponding authors

Correspondence to Tao Li or Jianfeng Zhou.

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Shen, Q., Liu, X., Pan, S. et al. Effectiveness of indocyanine green fluorescence imaging in resection of hepatoblastoma. Pediatr Surg Int 39, 181 (2023). https://doi.org/10.1007/s00383-023-05465-3

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  • DOI: https://doi.org/10.1007/s00383-023-05465-3

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