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Incidence and antiviral treatment of cytomegalovirus infection in infants with biliary atresia

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Abstract

Purpose

Patients with biliary atresia (BA) and cytomegalovirus (CMV) infection may have poorer outcomes after Kasai portoenterostomy (KPE) than uninfected patients, suggesting a rationale for antiviral treatment (AVT). We aimed to describe the incidence of CMV infection and of AVT in BA patients, and to detect any differences between infected and uninfected patients to conclude if AVT is of use.

Methods

Data on BA patients who underwent KPE 2004–2020 were retrospectively collected, and the outcome was analyzed with regard to CMV status.

Results

Fifteen out of forty-six (33%) BA patients had signs of ongoing CMV infection. They did not differ significantly from the CMV-negative patients regarding rate of prematurity, birth weight, or biochemical markers but were slightly older at KPE. All patients received steroids postoperatively and all patients with ongoing CMV infection received AVT with very good effect on viremia and without major side effects. The AVT consisted of oral valganciclovir (10–40 (– 58) mg/kg/d) or intravenous ganciclovir (5.3–11 mg/kg/d).

Conclusion

Ongoing CMV infection is common in this group of patients. The viremia can effectively be treated with AVT without any major side effects. Larger, randomized studies are needed to clarify the possible effect on clinical outcome.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Pediatrics, Astrid Lindgren Children’s Hospital, Karolinska University Hospital Solna, ST Pediatrik S304 Norrbacka, Eugeniavägen 27, 171 76, Stockholm, Sweden

    Ulrika Liliemark & Björn Fischler

  2. Department of Pediatric Surgery, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden

    Jan F. Svensson

  3. Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden

    Jan F. Svensson

  4. CLINTEC, Karolinska Institutet, Stockholm, Sweden

    Björn Fischler

Authors
  1. Ulrika Liliemark
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  2. Jan F. Svensson
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  3. Björn Fischler
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Contributions

All authors contributed to the study conception and design. Data collection and analysis were performed by UL. The first draft of the manuscript was written by UL and all authors contributed to previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Ulrika Liliemark.

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Liliemark, U., Svensson, J.F. & Fischler, B. Incidence and antiviral treatment of cytomegalovirus infection in infants with biliary atresia. Pediatr Surg Int 39, 117 (2023). https://doi.org/10.1007/s00383-023-05394-1

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