Skip to main content
Log in

Evaluation of the intraoperative risk factors for esophageal anastomotic complications after primary repair of esophageal atresia with tracheoesophageal fistula

  • Original Article
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study is to identify the risk factors for esophageal anastomotic stricture (EAS) and/or anastomotic leakage (EAL) after primary repair of esophageal atresia with tracheoesophageal fistula (EA/TEF) in infants.

Methods

A retrospective chart review of 52 patients with congenital EA/TEF between January 2000 and December 2015 was conducted. Univariate and multivariate analyses were performed to identify the risk factors for anastomotic complications.

Results

Twenty-four patients were excluded from the analysis because they had insufficient data, trisomy 18 syndrome, delayed anastomosis, or multi-staged operations; the remaining 28 were included. Twelve patients (42.9 %) had anastomotic complications. EAS occurred in 12 patients (42.9 %), and one of them had EAL (3.57 %). There was no correlation between anastomotic complications and birth weight, gestational weeks, sex, the presence of an associated anomaly, age at the time of repair, gap between the upper pouch and lower pouch of the esophagus, number of sutures, blood loss, and gastroesophageal reflux. Anastomosis under tension and tracheomalacia were identified as risk factors for anastomotic complications (odds ratio 15, 95 % confidence interval (CI) 1.53–390.0 and odds ratio 8, 95 % CI 1.33–71.2, respectively).

Conclusion

Surgeons should carefully perform anastomosis under less tension to prevent anastomotic complications in the primary repair of EA/TEF.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Nice T, Tuanama Diaz B, Shroyer M, Rogers D, Chen M, Martin C, Beierle E, Chaignaud B, Anderson S, Russell R (2016) Risk factors for stricture formation after esophageal atresia repair. J Laparoendosc Adv Surg Tech A 393–8. doi:10.1089/lap.2015.0120

  2. Pini Prato A, Carlucci M, Bagolan P, Gamba PG, Bernardi M, Leva E, Paradies G, Manzoni C, Noccioli B, Tramontano A, Jasonni V, Vaccarella F, De Pascale S, Alberti D, Riccipetitoni G, Falchetti D, Caccia F, Pelizzo G, Schleef J, Lima M, Andriolo P, Franchella A, Cacciari A, Caravaggi F, Federici S, Andermarcher M, Perrino G, Codrich D, Camoglio FS, Chiarenza FS, Martino A, Appignani A, Briganti V, Caterino S, Cozzi D, Messina M, Rizzo A, Liotta L, Salerno D, Aceti MG, Bartoli F, Romeo C, Esposito C, Lelli Chiesa PL, Clemente E, Mascia L, Cacciaguerra S, Di Benedetto V, Licciardi S, De Grazia E, Ubertazzi M, Piazza G, Mattioli G, Rossi F, Nobili M (2015) A cross-sectional nationwide survey on esophageal atresia and tracheoesophageal fistula. J Pediatr Surg 50:1441–1456. doi:10.1016/j.jpedsurg.2015.01.004

    Article  CAS  PubMed  Google Scholar 

  3. Dingemann C, Dietrich J, Zeidler J, Blaser J, Gosemann JH, Ure BM, Lacher M (2015) Early complications after esophageal atresia repair: analysis of a German health insurance database covering a population of 8 million. Dis Esophagus. doi:10.1111/dote.12369

    PubMed  Google Scholar 

  4. Wang B, Tashiro J, Allan BJ, Sola JE, Parikh PP, Hogan AR, Neville HL, Perez EA (2014) A nationwide analysis of clinical outcomes among newborns with esophageal atresia and tracheoesophageal fistulas in the United States. J Surg Res 190:604–612. doi:10.1016/j.jss.2014.04.033

    Article  PubMed  Google Scholar 

  5. Allin B, Knight M, Johnson P, Burge D (2014) Outcomes at one-year post anastomosis from a national cohort of infants with oesophageal atresia. PLoS One 9:e106149. doi:10.1371/journal.pone.0106149

    Article  PubMed  PubMed Central  Google Scholar 

  6. Shah R, Varjavandi V, Krishnan U (2015) Predictive factors for complications in children with esophageal atresia and tracheoesophageal fistula. Dis Esophagus 28:216–223. doi:10.1111/dote.12177

    Article  CAS  PubMed  Google Scholar 

  7. Sun LY, Laberge JM, Yousef Y, Baird R (2015) The esophageal anastomotic stricture index (EASI) for the management of esophageal atresia. J Pediatr Surg 50:107–110. doi:10.1016/j.jpedsurg.2014.10.008

    Article  PubMed  Google Scholar 

  8. Spitz L, Kiely E, Brereton RJ (1987) Esophageal atresia: five year experience with 148 cases. J Pediatr Surg 22:103–108

    Article  CAS  PubMed  Google Scholar 

  9. Chittmittrapap S, Spitz L, Kiely EM, Brereton RJ (1990) Anastomotic stricture following repair of esophageal atresia. J Pediatr Surg 25:508–511

    Article  CAS  PubMed  Google Scholar 

  10. Castilloux J, Noble AJ, Faure C (2010) Risk factors for short- and long-term morbidity in children with esophageal atresia. J Pediatr 156:755–760. doi:10.1016/j.jpeds.2009.11.038

    Article  PubMed  Google Scholar 

  11. Tsai JY, Berkery L, Wesson DE, Redo SF, Spigland NA (1997) Esophageal atresia and tracheoesophageal fistula: surgical experience over two decades. Ann Thorac Surg 64:778–783 (discussion 783–774)

    Article  CAS  PubMed  Google Scholar 

  12. Schneider A, Blanc S, Bonnard A, Khen-Dunlop N, Auber F, Breton A, Podevin G, Sfeir R, Fouquet V, Jacquier C, Lemelle JL, Lavrand F, Becmeur F, Petit T, Poli-Merol ML, Elbaz F, Merrot T, Michel JL, Hossein A, Lopez M, Habonimana E, Pelatan C, De Lagausie P, Buisson P, de Vries P, Gaudin J, Lardy H, Borderon C, Borgnon J, Jaby O, Weil D, Aubert D, Geiss S, Breaud J, Echaieb A, Languepin J, Laplace C, Pouzac M, Lefebvre F, Gottrand F, Michaud L (2014) Results from the French National Esophageal Atresia register: one-year outcome. Orphanet J Rare Dis 9:206. doi:10.1186/s13023-014-0206-5

    Article  PubMed  PubMed Central  Google Scholar 

  13. Serhal L, Gottrand F, Sfeir R, Guimber D, Devos P, Bonnevalle M, Storme L, Turck D, Michaud L (2010) Anastomotic stricture after surgical repair of esophageal atresia: frequency, risk factors, and efficacy of esophageal bougie dilatations. J Pediatr Surg 45:1459–1462. doi:10.1016/j.jpedsurg.2009.11.002

    Article  PubMed  Google Scholar 

  14. Sulkowski JP, Cooper JN, Lopez JJ, Jadcherla Y, Cuenot A, Mattei P, Deans KJ, Minneci PC (2014) Morbidity and mortality in patients with esophageal atresia. Surgery 156:483–491. doi:10.1016/j.surg.2014.03.016

    Article  PubMed  PubMed Central  Google Scholar 

  15. Sfeir R, Bonnard A, Khen-Dunlop N, Auber F, Gelas T, Michaud L, Podevin G, Breton A, Fouquet V, Piolat C, Lemelle JL, Petit T, Lavrand F, Becmeur F, Polimerol ML, Michel JL, Elbaz F, Habonimana E, Allal H, Lopez E, Lardy H, Morineau M, Pelatan C, Merrot T, Delagausie P, de Vries P, Levard G, Buisson P, Sapin E, Jaby O, Borderon C, Weil D, Gueiss S, Aubert D, Echaieb A, Fourcade L, Breaud J, Laplace C, Pouzac M, Duhamel A, Gottrand F (2013) Esophageal atresia: data from a national cohort. J Pediatr Surg 48:1664–1669. doi:10.1016/j.jpedsurg.2013.03.075

    Article  PubMed  Google Scholar 

  16. Thakkar HS, Cooney J, Kumar N, Kiely E (2014) Measured gap length and outcomes in oesophageal atresia. J Pediatr Surg 49:1343–1346. doi:10.1016/j.jpedsurg.2014.03.021

    Article  PubMed  Google Scholar 

  17. Shawyer AC, Pemberton J, Flageole H (2014) Post-operative management of esophageal atresia-tracheoesophageal fistula and gastroesophageal reflux: a Canadian Association of Pediatric Surgeons annual meeting survey. J Pediatr Surg 49:716–719. doi:10.1016/j.jpedsurg.2014.02.052

    Article  PubMed  Google Scholar 

  18. Tovar JA, Fragoso AC (2013) Anti-reflux surgery for patients with esophageal atresia. Dis Esophagus 26:401–404. doi:10.1111/dote.12063

    Article  CAS  PubMed  Google Scholar 

  19. Murase N, Uchida H, Kaneko K, Ono Y, Makita S, Yokota K (2015) Prophylactic effect of H2 blocker for anastomotic stricture after esophageal atresia repair. Pediatr Int 57:461–464. doi:10.1111/ped.12529

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yuichi Okata.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study, formal consent is not required.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Okata, Y., Maeda, K., Bitoh, Y. et al. Evaluation of the intraoperative risk factors for esophageal anastomotic complications after primary repair of esophageal atresia with tracheoesophageal fistula. Pediatr Surg Int 32, 869–873 (2016). https://doi.org/10.1007/s00383-016-3931-0

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00383-016-3931-0

Keywords

Navigation