Abstract
We describe the first case of regression of a white epidermoid cyst in a child. White epidermoid cysts are rare benign lesions, particularly in pediatric cases. Typically, these cysts need surgical resection. However, we report the case of a 3-year-old child with recurrent aseptic meningitis, in whom CT scan and MRI revealed a white epidermoid cyst in the pre-bulbar cistern. Surprisingly, over a 5-year follow-up period, the cyst showed dramatic regression without any symptoms. This case sheds light on the potential for spontaneous regression of white epidermoid cysts in children, challenging the need for risky surgical interventions. This report opens up new perspectives on the pathophysiology and management options for this type of lesion in children.
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References
Kumar S, Sahana D, Rathore L, Sahu RK, Jain A, Borde P, Tawari M, Madhariya SN (2021) Fourth Ventricular epidermoid cyst — case series, systematic review and analysis. Asian J Neurosurg 16(3):470–482. https://doi.org/10.4103/ajns.AJNS_539_20. PMID: 34660356; PMCID: PMC8477812
Gao PY, Osborn AG, Smirniotopoulos JG, Harris CP (1992) Radiologic-pathologic correlation. Epidermoid tumor of the cerebellopontine angle. AJNR Am J Neuroradiol 13:863–872
Ohara T, Maki S, Furuya T, Inada T, Kamiya K, Ota M, Okawa A, Ikeda O, Takahashi K, Yamazaki M, Koda M (2015) Elderly onset intramedullary epidermoid cyst in the conus medullaris: a case report. J Med Case Rep 9(1):7. https://doi.org/10.1186/1752-1947-9-7. PMID:25582755; PMCID: PMC4326493
Takeshita M, Kubo O, Hiyama H, Tajika Y, Izawa M, Kagawa M, Takakura K, Kobayashi N, Toyoda M (1994) Magnetic resonance imaging and quantitative analysis of contents of epidermoid and dermoid cysts. Neurol Med Chir (Tokyo) 34(7):436–439. https://doi.org/10.2176/nmc.34.436. PMID: 7526232
Jamjoom DZ, Alamer A, Tampieri D (2022) Correlation of radiological features of white epidermoid cysts with histopathological findings. Sci Rep 12(1):2314. https://doi.org/10.1038/s41598-022-06167-x. PMID:35145173; PMCID: PMC8831518
Tampieri D, Melanson D, Ethier R (1989) MR imaging of epidermoid cysts. AJNR 10(2):351–356
Li F, Zhu S, Liu Y, Chen G, Chi L, Qu F (2007) Kystes épidermoïdes intracrâniens hyperdenses : une étude de 15 cas. Acta Neurochir (Wien). 149(1):31–9; discussion 39. https://doi.org/10.1007/s00701-006-1060-6. Epub 2006 11 décembre. PMID: 17151831
Mishra SS, Panigrahi S, Dhir MK, Pattajoshi AS (2014) Intrinsic brainstem white epidermoid cyst: an unusual case report. J Pediatr Neurosci 9(1):52–54
Singh SS, Gupta K, Kumaran SP, Ghosal N, Furtado SV (2012) Pontomedullary white epidermoid: a rare cause of tinnitus. Singap Med J 53(8):179–181
Lundy P, Grabb P (2020) A rare case of a pediatric white epidermoid cyst. Childs Nerv Syst 36(8):1795–1798. https://doi.org/10.1007/s00381-020-04507-8. Epub 2020 Jan 14 PMID: 31938868
Patibandla MR, Yerramneni VK, Mudumba VS, Manisha N, Addagada GC (2016) Brainstem epidermoid cyst: an update. Asian J Neurosurg 11(3):194–200. https://doi.org/10.4103/1793-5482.145163. PMID: 27366244; PMCID: PMC4849286
Shah A, Makkiyah F, Goel A (2016) Sylvian fissure epidermoid cyst presenting with intention tremor. Asian J Neurosurg 11:174–175
Lopez Gomez P, Mato Mañas D, Marco de Lucas E (2021) Epidermoid cyst extending along trigeminal nerve pathway with unusual imaging findings. World Neurosurg. 146:75–77. https://doi.org/10.1016/j.wneu.2020.10.148. Epub 2020 Nov 2. PMID: 33144211
Tatagiba M, Iaconetta G, Samii M (2000) Epidermoid cyst of the cavernous sinus: clinical features, pathogenesis and treatment. Br J Neurosurg 14:571–575
Bucciero A, Del Basso De Caro ML, Carraturo S, Vizioli L, Cerillo A, Tedeschi G (1995) Supratentorial dermoid cysts. Presentation and management of five cases. J Neurosurg Sci 39(1):7–11. PMID: 8568557
Kriss TC, Kriss VM, Warf BC (1995) Recurrent meningitis: the search for the dermoid or epidermoid tumor. Pediatr Infect Dis J 14:697–700
Baujat G, Le Masne A, Cinalli G, Abadie V (1998) Méningite à Escherichia coli chez un nourrisson de 16 mois révélant un kyste épidermoïde de la fosse postérieure [Escherichia coli meningitis in a 16-month old infant revealing a posterior fossa epidermoid cyst]. Arch Pediatr. 5(9):988–91. French. https://doi.org/10.1016/s0929-693x(98)80008-0. PMID: 9789630
Kobayashi T, Kuchiwaki H, Inao S, Nakashima N (1993) A squamous cell carcinoma originated from intracranial dermoid cyst. Neurochirurgia (Stuttg) 36(1):26–29. https://doi.org/10.1055/s-2008-1053791. PMID: 8446293
Ochi M, Hayashi K, Hayashi T, Morikawa M, Ogino A, Hashmi R, Iwanaga M, Yasunaga A, Shibata S (1998) Unusual CT and MR appearance of an epidermoid tumor of the cerebellopontine angle. AJNR Am J Neuroradiol 19(6):1113–5. PMID: 9672021; PMCID: PMC8338666
Ginat DT, Meyers SP (2012) Intracranial lesions with high signal intensity on T1-weighted MR images: differential diagnosis. Radiographics 32(2):499–516
Aggarwal V, Narang A, Jain R, Maheshwari C, Kavita D (2021) Surgical nuances of intramedullary white epidermoid cyst in the conus medullaris: a rare entity. Asian J Neurosurg 16(3):614–617. https://doi.org/10.4103/ajns.AJNS_321_20. PMID:34660381; PMCID: PMC8477828
Gosal JS, Garg M, Tiwari S, Das KK, Jha DK (2021) White epidermoid: an important radiological mimic of the dermoid. Childs Nerv Syst 37(3):737–738. https://doi.org/10.1007/s00381-020-04883-1. Epub 2020 Sep 11 PMID: 32918137
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J.M and O.K wrote the main manuscrit. E.M prepared all the figures. All authors reviewed the manuscrit.
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Malczuk, J., Costachescu, B., Schmitt, E. et al. Spontaneous regression of white epidermoid cyst of the pre-bulbar cistern in a 3-year-old child: a case report and literature review. Childs Nerv Syst 39, 3065–3070 (2023). https://doi.org/10.1007/s00381-023-06140-7
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DOI: https://doi.org/10.1007/s00381-023-06140-7