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Pediatric benign triton tumor of trigeminal nerve: a case report and literature review

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Abstract

Purpose

Benign triton tumors (BTTs) in the pediatric population are extremely rare occurrences. Paucity of data on BTTs poses both diagnostic and therapeutic challenges, particularly when found intracranially.

Methods

A case report of a 10-year-old male diagnosed with incidental maxillary trigeminal (V2) BTT is presented. We discuss radiographic and histopathological interpretations. Furthermore, we provide a brief review of current literature and historical background on pediatric trigeminal BTT diagnosis, histopathology, and management.

Results

Successful gross total resection of the tumor was achieved via Dolenc approach to the cavernous sinus. Management options with consideration of outcomes from the few prior cases reported in the literature are presented.

Conclusion

Treatment of trigeminal nerve tumors requires a broad differential diagnosis and understanding rare tumors is essential in the diagnosis and treatment algorithm.

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All data generated or analyzed during this study are included in the article.

References

  1. Awasthi D, Kline DG, Beckman EN (1991) Neuromuscular hamartoma (benign “triton” tumor) of the brachial plexus. J Neurosurg 75(5):795–797. https://doi.org/10.3171/jns.1991.75.5.0795

    Article  PubMed  CAS  Google Scholar 

  2. Thakrar R, Robson CD, Vargas SO, Meara JG, Rahbar R, Smith ER (2014) Benign triton tumor: multidisciplinary approach to diagnosis and treatment. Pediatr Dev Pathol Sep-Oct 17(5):400–405. https://doi.org/10.2350/14-04-1459-CR.1

    Article  Google Scholar 

  3. Louhimo I, Rapola J (1972) Intraneural muscular hamartoma: report of two cases in small children. J Pediatr Surg 7:696–699

    Article  PubMed  CAS  Google Scholar 

  4. Castro DE, Raghuram K, Phillips CD (2005) Benign triton tumor of the trigeminal nerve. Amer J of Neurorad 26(4):967–969

    Google Scholar 

  5. Tobias S, Kim CH, Sade B, Staugaitis SM, Lee JH (2006) Neuromuscular hamartoma of the trigeminal nerve in an adult. Acta Neurochir (Wien) 148(1):83–87. https://doi.org/10.1007/s00701-005-0642-z

    Article  CAS  Google Scholar 

  6. Akimoto J, Fukami S, Hashimoto R, Haraoka J (2012) Neuromuscular hamartoma is a possible primary pathology of oculomotor ophthalmoplegic migraine. Cephalalgia 32(2):171–174. https://doi.org/10.1177/0333102411431331

    Article  PubMed  Google Scholar 

  7. Bassett GS, Monforte-Munoz H, Mitchell WG, Rowland JM (1997) Cavus deformity of the foot secondary to a neuromuscular choristoma (hamartoma) of the sciatic nerve. A case report. J Bone Joint Surg Am 79(9):1398–1401. https://doi.org/10.2106/00004623-199709000-00016

  8. Demir Y, Uluoglu O, Ozmen S, Boyacioglu ZM, Atabay K (2003) Neuromuscular hamartoma in the mental region. J Oral Maxillofac Surg 61(3):397–400. https://doi.org/10.1053/joms.2003.50066

    Article  PubMed  Google Scholar 

  9. Markel SF, Enzinger FM (1982) Neuromuscular hamartoma–a benign “triton tumor” composed of mature neural and striated muscle elements. Cancer 49:140–144

    Article  PubMed  CAS  Google Scholar 

  10. Amita K, Shankar SV, Nischal KC, Basavaraj HB (2013) Benign triton tumor: a rare entity in head and neck region. Korean J Pathol 47(1):74–76. https://doi.org/10.4132/KoreanJPathol.2013.47.1.74

    Article  PubMed  PubMed Central  Google Scholar 

  11. Bae DH, Kim CH, Cheong JH, Kim JM (2014) Adulthood benign triton tumor developed in the orbit. J Korean Neurosurg Soc 56(2):146–148. https://doi.org/10.3340/jkns.2014.56.2.146

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Daley TD, Darling MR, Wehrli B (2008) Benign triton tumor of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(6):763–766. https://doi.org/10.1016/j.tripleo.2007.09.005

    Article  PubMed  Google Scholar 

  13. Malhotra A, Tu L, Kalra VB et al (2018) Neuroimaging of Meckel’s cave in normal and disease conditions. Insights Imaging 9:499–510. https://doi.org/10.1007/s13244-018-0604-7

    Article  PubMed  PubMed Central  Google Scholar 

  14. Yuh WTC, Wright DC, Barloon TJ, Schultz DH, Sato Y, Cervantes CA (1988) MR Imaging of primary tumors of trigeminal nerve and Meckel’s cave. AJR 151:577–582

  15. Lena G, Dufour T, Gambrelli D et al (1994) Choristoma of the intracranial maxillary nerve in a child: case report. J Neurosurg 81:788–791

    Article  PubMed  CAS  Google Scholar 

  16. Vajramani G, Devi I, Santosh V et al (1999) Benign triton tumor of the trigeminal nerve. Childs Nerv Syst 15:140–144

    Article  PubMed  CAS  Google Scholar 

  17. Abdel Razek AAK, Gamaleldin OA, Elsebaie NA (2020) Peripheral nerve sheath tumors of head and neck: imaging-based review of World Health Organization classification. J Comput Assist Tomogr 44(6):928–940

  18. Hébert-Blouin M, Scheithauer BW, Amrami KK, Durham SR, Spinner RJ (2012) Fibromatosis: a potential sequela of neuromuscular choristoma. J Neurosurg 116(2):399–408. https://doi.org/10.3171/2011.6.JNS102171

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurological Surgery, University of Illinois at Chicago, Chicago, IL, USA

    Sophia Peng

  2. Division of Neurosurgery, Ann & Robert H Lurie Children’s Hospital, 225 E Chicago Ave, Box 28, Chicago, IL, 60611, USA

    Mandana Behbahani, Shelly Sharma, Stacy Speck & Tord D. Alden

  3. Department of Pathology, Ann & Robert H Lurie Children’s Hospital, Chicago, IL, USA

    Nitin R. Wadhwani

  4. Division of Otolaryngology, Ann & Robert H Lurie Children’s Hospital, Chicago, IL, USA

    Jeff C. Rastatter

  5. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Tord D. Alden

  6. Division of Pediatric Neurosurgery, Ann & Robert H Lurie Children’s Hospital, 225 E. Chicago Avenue, Chicago, IL, USA

    Tord D. Alden

Authors
  1. Sophia Peng
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  2. Mandana Behbahani
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  3. Shelly Sharma
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  4. Stacy Speck
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  5. Nitin R. Wadhwani
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  6. Jeff C. Rastatter
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  7. Tord D. Alden
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Sophia Peng, Mandana Behbahani, and Shelly Sharma. The surgical management team consisted of Drs. Sophia Peng, Mandana Behbahani, Ms. Stacy Speck, Drs. Jeff Rastatter, and Tord Alden. The procedure was completed by Drs. Sophia Peng, Mandana Behbahani, Jeff Rastatter, and Tord Alden. Dr. Tord Alden was the lead surgeon on this case. Histopathology was completed by Dr. Nitin R. Wadhwani. The first draft of the manuscript was written by Sophia Peng and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Tord D. Alden.

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The authors have no competing interests to declare that are relevant to the content of this article. The authors declare no competing interests.

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Peng, S., Behbahani, M., Sharma, S. et al. Pediatric benign triton tumor of trigeminal nerve: a case report and literature review. Childs Nerv Syst 38, 2055–2061 (2022). https://doi.org/10.1007/s00381-022-05641-1

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  • DOI: https://doi.org/10.1007/s00381-022-05641-1

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