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Pineal anlage tumor: a case report and review of the literature

  • Case Report
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Abstract

Purpose

Pineal anlage tumors (PAT) are extremely rare malignant tumors in the pediatric population considered to be a variant of pineoblastomas. These tumors are characterized by a combination of neuroectodermal and heterologous ectomesenchymal components. PAT can be clinically aggressive and has a propensity to cerebrospinal fluid (CSF) dissemination. So far, only 13 cases of these tumors have been reported in the literature.

Case Article

In this article, we report the case of an anlage tumor in a 3-year-old girl with a rapidly aggressive course.

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Abbreviations

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

CT:

Computerized tomography

MNTI:

Melanotic neuroectodermal tumor of childhood

MRI:

Magnetic resonance imaging

PAT:

Pineal anlage tumor

WHO:

World Health Organization

References

  1. Favero G, Bonomini F, Rezzani R (2021) Pineal gland tumors: a review. Cancers 13(7):1547

    CAS  PubMed  Google Scholar 

  2. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger et al (2021) Neuro Oncol 23(8):1231–1251

    Article  CAS  Google Scholar 

  3. Mc Grogan G, Rivel J, Vital C, Guerin JA (1992) Pineal tumor with features of pineal anlage tumor. Acta Neurochir 117:73–77

    Article  CAS  Google Scholar 

  4. Ahuja A, Sharma MC, Suri V, Sarkar C, Sharma BS, Garg A (2011) Pineal anlage tumor – a rare entity with divergent histology. J Clin Neurosci 18:811–813

    Article  Google Scholar 

  5. Uppal DK, Madan R, Chatterjee D et al (2021) Pineal anlage tumor: a case report and infant-pathological review. Clin Neurol Neurosurg 206:106629

  6. Schmidbauer M, Budka H, Pilz P (1989) Neuroepithelial and ectomesenchymal differentiation in a primitive pineal tumor (pineal anlage tumor). Clin Neuropathol 8:7–10

    CAS  PubMed  Google Scholar 

  7. Raisanen J, Vogel H, Horoupian DS (1990) Primitive pineal tumor with retinoblastomatous and retinal/ciliary epithelial differentiation: an immunohistochemical study. J Neurooncol 9:165–170

    Article  CAS  Google Scholar 

  8. Gudinaviciene I, Pranys D, Zheng P, Kros JMA (2005) 10-month-old boy with a large pineal tumor. Brain Pathol 15:263–264

    Article  Google Scholar 

  9. Berns S, Pearl G (2006) Review of pineal anlage tumor with divergent histology. Arch Pathol Lab Med 130:1233–1235

    Article  Google Scholar 

  10. Olaya JE, Raghavan R, Totaro L, Zouros A (2010) Pineal anlage tumor in a 5-month-old boy. J Meurosurg Pediatrics 5:636–640

    Article  Google Scholar 

  11. Rodríguez-Velasco A, Ramírez-Reyes AG (2014) Tumor pineal anlage en un niño de 8 meses. Primer caso informado en lengua hispana Rev Med Inst Mex Seguro Soc 52(Suppl 2):S90–S93

    Google Scholar 

  12. Ajayi O, Palma A, Sadanand V, Deisch J (2014) Pineal anlage tumor: case report and review of literature. JSM Neurosurg Spine 2(4):1035

    Google Scholar 

  13. Ramdasi R, Kothari K, Goel N, Mahore A (2015) An unusual variant of anlage tumor of pineal region in an infant. Brain Tumor Res Treat 3:52–55

    Article  Google Scholar 

  14. Homma T, Hemmi A, Ohta T, Kusumi Y, Yoshino A, Hao H (2017) A rare case of a pineoblastoma with a rhabdomyoblastic component. Neuropathology 37:227–232

    Article  CAS  Google Scholar 

  15. Li JY, Chen L (2020) Pineal anlage tumor: report of a case. Chin J Pathol 49(11):1190–1192

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Federal University of Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Eduardo Cambruzzi

  2. Santa Casa Hospital Complex, Porto Alegre, Rio Grande do Sul, Brazil

    Eduardo Cambruzzi

  3. Conceição Hospital Group, Porto Alegre, Rio Grande do Sul, Brazil

    Eduardo Cambruzzi, Mateus Scarabelot Medeiros, Jose Nathan Andrade Muller da Silva, Gabriella Bezerra Cortês Nascimento, Natália Brandelli Zandoná & Willian Pegoraro Kus

  4. Institute of Cardiology, University Foundation of Cardiology, Porto Alegre, Rio Grande do Sul, Brazil

    Eduardo Cambruzzi

  5. Faculty of Medicine, Unisinos, Sao Leopoldo, Rio Grande do Sul, Brazil

    Eduardo Cambruzzi

  6. Department of Pathology, Santa Rita Hospital, Complexo Hospitalar Santa Casa, Rua Sarmento Leite, 187, 2º andar, Porto Alegre, RS, Brazil

    Eduardo Cambruzzi

Authors
  1. Eduardo Cambruzzi
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  2. Mateus Scarabelot Medeiros
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  3. Jose Nathan Andrade Muller da Silva
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  4. Gabriella Bezerra Cortês Nascimento
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  5. Natália Brandelli Zandoná
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  6. Willian Pegoraro Kus
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Corresponding author

Correspondence to Eduardo Cambruzzi.

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Cambruzzi, E., Medeiros, M.S., da Silva, J.N.A.M. et al. Pineal anlage tumor: a case report and review of the literature. Childs Nerv Syst 38, 1625–1629 (2022). https://doi.org/10.1007/s00381-021-05441-z

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  • DOI: https://doi.org/10.1007/s00381-021-05441-z

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