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Effects of lacosamide “a novel antiepileptic drug” in the early stages of chicken embryo development

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Abstract

Introduction

Antiepileptic drugs (AEDs) are teratogens and confer a risk of congenital malformation. The estimated prevalence of major congenital malformations such as cardiac defects, facial clefts, hypospadias, and neural tube defects in epileptic women is 4–10 %, which represents a two- to fourfold increase in pregnant women compared to the general population. However, there are no clear data for newer drugs. Lacosamide (LCM), a novel AED, is the first of the third-generation AEDs to be approved as adjunctive therapy for the treatment of partial-onset seizures. There are no data on the pharmacokinetics of LCM during pregnancy, and only some published data have reported on its effects during pregnancy.

Methods

In this study, three different doses of LCM (0.12, 0.5, and 1.60 mg in 0.18 mL) were applied under the embryonic disks of specific pathogen-free Leghorn chicken embryos after a 30-h incubation. Incubation was continued for 80 h, at which time all embryos were evaluated macroscopically and microscopically.

Results

There was growth retardation in all of the LCM-treated groups. Major malformations increased in a dose-dependent manner and were mostly observed in the supratherapeutic group.

Conclusion

Based on our data, LCM may cause growth retardation or major congenital malformations. Nevertheless, more extensive investigations of its reliability are needed.

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Acknowledgments

The authors would like to thank to Dr. Nayif YILMAZ for his assistance in obtaining the drugs.

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Authors and Affiliations

  1. Department Neurosurgery, Celal Bayar University School of Medicine, Yelken Evleri Sitesi B Blok k:5 d:16 Güzelyurt, Manisa, Turkey

    Mesut Mete, Ulkun Unlu Unsal, Yusuf Kurtulus Duransoy & Mehmet Selcuki

  2. Department of Biology, Faculty of Science and Letters Zoology Section, Celal Bayar University, Manisa, Turkey

    Beyhan Gurcu & Fatih Collu

  3. Department of Histology-Embryology, Celal Bayar University School of Medicine, Manisa, Turkey

    Mehmet Ibrahim Tuglu

Authors
  1. Mesut Mete
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  2. Beyhan Gurcu
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  3. Fatih Collu
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  4. Ulkun Unlu Unsal
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  5. Yusuf Kurtulus Duransoy
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  6. Mehmet Ibrahim Tuglu
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  7. Mehmet Selcuki
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Corresponding author

Correspondence to Mesut Mete.

Ethics declarations

All experiments were conducted in accordance with the animal research protocol of Celal Bayar University Ethics Committee (no. 77.637.4335–27).

Conflict of interest

Authors declare that there is no conflict of interest.

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Mete, M., Gurcu, B., Collu, F. et al. Effects of lacosamide “a novel antiepileptic drug” in the early stages of chicken embryo development. Childs Nerv Syst 32, 1715–1719 (2016). https://doi.org/10.1007/s00381-016-3181-4

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  • DOI: https://doi.org/10.1007/s00381-016-3181-4

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