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Leptin concentration and nutritional status in the course of treatment in children with brain tumours—preliminary report

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Abstract

Purpose

To assess the nutritional status in children with central nervous system (CNS) tumours, including concentration of leptin, the neuropeptide responsible for regulation of energetic homeostasis in an organism.

Method

The studied group comprised 44 children with brain tumours, aged (4.02–18.7). In all children during the whole therapy (from the start to the period of 1 year and more after the end of therapy), a number of standard deviations (SDs) for the body mass index (SDS BMI) was derived from anthropometric measurements. Concentrations of leptin were assayed simultaneously.

Result

The lowest values of the anthropometric indices were found in children during the maintenance therapy. Concentrations of leptin in patients with malignant CNS tumours and significant undernutrition were slightly greater as compared to patients presenting normal nutritional status; however, without statistical significance.

Conclusion

In children with tumours of the central nervous system, there are quantitative disorders of the nutritional status which correlate with the period of the treatment. The most significant disorders in the nutritional status are observed during maintenance chemotherapy. There was no statistically significant correlation between the concentration of leptin and nutritional status in children with malignant brain tumours during the course of treatment and after its completion.

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References

  1. Anagnostoulis S, Karayiannalics AJ, Lambropoulou M, Efthimidaou A, Polychronidis A, Simopoulos C (2008) Human leptin induces angiogenesis in vivo. Cytokine 42:353–357

    Article  CAS  PubMed  Google Scholar 

  2. Arisan ED, Arisan S, Atis G, Palavan-Unsal N, Ergenekon E (2009) Serum adipocytokine levels in prostate cancer patients. Urol Int 82:203–208

    Article  CAS  PubMed  Google Scholar 

  3. Badman MK, Flier JS (2007) The adipocyte as an active participant in energy balance and metabolism. Gastroenterology 132:2103–2115

    Article  CAS  PubMed  Google Scholar 

  4. Barker LA, Gout BS, Crowe TC (2011) Hospital malnutrition: prevalence, identification and impact on patients and the healthcare system. Int J Environ Res Public Health 8(2):514–527, Epub 2011 Feb 16

    Article  PubMed  Google Scholar 

  5. Bennani-Baiti N, Davis AM (2008) Cytokines and cancer anorexia cachexia syndrome. Am J Hosp Palliat Care 25:407–411

    Article  PubMed  Google Scholar 

  6. Birkebaek NH, Fisker S, Clausen N, Tuovinen V, Sindet-Pedersen S, Christiansen JS (1998) Growth and endocrinological disorders up to 21 years after treatment for acute lymphoblastic leukemia in childhood. Med Pediatr Oncol 30:351–356

    Article  CAS  PubMed  Google Scholar 

  7. Brennan BM, Rahim A, Blum WF, Adams JA, Eden OB, Shalet SM (1999) Hyperleptynemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity? Clin Endocrinol (Oxf) 50(2):163–169

    Article  CAS  Google Scholar 

  8. Correia MI, Waitzberg DL (2003) The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr 22:235–239

    Article  PubMed  Google Scholar 

  9. Farooqi IS, O’Rahilly S (2009) Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 89(3):980S–984S, Epub 2009 Feb 11

    Article  CAS  PubMed  Google Scholar 

  10. Friedman JM (2011) Leptin and the regulation of body weight. Keio J Med 60(1):1–9

    Article  CAS  PubMed  Google Scholar 

  11. Laviano A, Inui A, Marks D, Meguid MM, Pichard C, Rossi Fanelli F, Seelaender M (2008) Neural control of the anorexia–cachexia syndrome. Am J Physiol Endocrinol Metab 295:E1000–E1008

    Article  CAS  PubMed  Google Scholar 

  12. Münzberg H, Björnholm M, Bates SH, Myers MG Jr (2005) Leptin receptor action and mechanisms of leptin resistance. Cell Mol Life Sci 62(6):642–652

    Article  PubMed  Google Scholar 

  13. Neary NM, Goldstone AP, Bloom SR (2004) Appetite regulation: from the gut to the hypothalamus. Clin Endocrinol 60:153–160

    Article  Google Scholar 

  14. Ogunwobi OO, Beales ILP (2007) The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. Int J Colorectal Dis 22:401–409

    Article  PubMed  Google Scholar 

  15. Skoczen S, Tomasik PJ, Bik-Multanowski M, Surmiak M, Balwierz W, Pietrzyk JJ, Sztefko K, Gozdzik J, Galicka-Latała D, Strojny W (2011) Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia. J Exp Clin Cancer 30(64)

  16. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI (1995) Identification and expression cloning of a leptin receptor OB-R. Cell 83(7):1263–1271

    Article  CAS  PubMed  Google Scholar 

  17. Tisdale MJ (2008) Catabolic mediators of cancer cachexia. Curr Opin Support Palliat Care 2:256–261

    Article  PubMed  Google Scholar 

  18. Van Cutsem E, Arends J (2005) The causes and consequences of cancer-associated malnutrition. Eur J Oncol Nurs 9:S51–S63

    Article  PubMed  Google Scholar 

  19. Van Eys J (1979) Malnutrition in children with cancer: incidence and consequence. Cancer 43:2030–2035

    Article  PubMed  Google Scholar 

  20. Venner AA, Lyon ME, Doyle-Baker PK (2006) Leptin: a potential biomarker for childhood obesity? Clin Biochem 39(11):1047–1056, Epub 2006 Aug 22

    Article  CAS  PubMed  Google Scholar 

  21. Wolf I, Sadetzki S, Kanety H (2006) Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients. Cancer 106(4):966–973

    Article  CAS  PubMed  Google Scholar 

  22. Zhang F, Chen Y, Heiman M, Dimarchi R (2005) Leptin: structure, function and biology. Vitam Horm 71:345–372

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Oncology, Hematology, and Chemotherapy, Upper Silesia Children’s Care Health Centre, Medical University of Silesia, 16 Medykow Str., 40-752, Katowice, Poland

    Katarzyna Musiol, Grazyna Sobol, Agnieszka Mizia-Malarz & Halina Wos

Authors
  1. Katarzyna Musiol
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  2. Grazyna Sobol
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  3. Agnieszka Mizia-Malarz
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  4. Halina Wos
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Correspondence to Katarzyna Musiol.

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Musiol, K., Sobol, G., Mizia-Malarz, A. et al. Leptin concentration and nutritional status in the course of treatment in children with brain tumours—preliminary report. Childs Nerv Syst 30, 131–136 (2014). https://doi.org/10.1007/s00381-013-2183-8

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  • DOI: https://doi.org/10.1007/s00381-013-2183-8

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