Skip to main content

Advertisement

Springer Nature Link
Log in

The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF)

  • Original Article
  • Published:
Heart and Vessels Aims and scope Submit manuscript

Abstract

Home telemonitoring is becoming more important to home medical care for patients with heart failure. Since there are no data on home telemonitoring for Japanese patients with heart failure, we investigated its effect on cardiovascular outcomes. The HOMES-HF study was the first multicenter, open-label, randomized, controlled trial (RCT) to elucidate the effectiveness of home telemonitoring of physiological data, such as body weight, blood pressure, and pulse rate, for Japanese patients with heart failure (UMIN Clinical Trials Registry 000006839). The primary end-point was a composite of all-cause death or rehospitalization due to worsening heart failure. We analyzed 181 recently hospitalized patients with heart failure who were randomly assigned to a telemonitoring group (n = 90) or a usual care group (n = 91). The mean follow-up period was 15 (range 0–31) months. There was no statistically significant difference in the primary end-point between groups [hazard ratio (HR), 0.95; 95% confidence interval (CI), 0.548–1.648; p = 0.572]. Home telemonitoring for Japanese patients with heart failure was feasible; however, beneficial effects in addition to those of usual care were not demonstrated. Further investigation of more patients with severe heart failure, participation of home medical care providers, and use of a more integrated home telemonitoring system emphasizing communication as well as monitoring of symptoms and physiological data are required.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Okura Y, Ramadan MM, Ohno Y, Mitsuma W, Tanaka K, Ito M, Suzuki K, Tanabe N, Kodama M, Aizawa Y (2008) Impending epidemic future-projection of heart failure in Japan to the year 2055. Circ J 72:489–491

    Article  PubMed  Google Scholar 

  2. Pandor A, Gomersall T, Stevens JW, Wang J, Al-Mohammad A, Bakhai A, Cleland JGF, Cowie MR, Wong R (2013) Remote monitoring after recent hospital discharge in patients with heart failure: a systematic review and network meta-analysis. Heart 99:1717–1726

    Article  PubMed  Google Scholar 

  3. Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, Lin Z, Phillips CO, Hodshon BV, Cooper LS, and Krumholz HM (2010) Telemonitoring in patients with heart failure. N Engl J Med 363:2301–2309 (Erratum in: (2013) N Engl J Med 369:1869. (2011) N Engl J Med 364:490)

  4. Koehler F, Winkler S, Schieber M, Sechtem U, Stangl K, Böhm M, Boll H, Baumann G, Honold M, Koehler K, Gelbrich G, Kirwan BA, Anker SD, On behalf of the Telemedical Interventional Monitoring in Heart Failure Investigators (2011) Impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure: the telemedical interventional monitoring in heart failure study. Circulation 123:1873–1880

    Article  PubMed  Google Scholar 

  5. Koehler F, Winkler S, Schieber M, Sechtem U, Stangl K, Böhm M, Brouwer S, Perrin E, Baumann G, Gelbrich G, Boll H, Honold M, Koehler K, Kirwan BA, Anker SD (2012) Telemedicine in heart failure: pre-specified and exploratory subgroup analyses from the TIM-HF trial. Int J Cardiol 29:143–150

    Article  Google Scholar 

  6. Kotooka N, Asaka M, Sato Y, Kinugasa Y, Nochioka K, Mizuno A, Nagatomo D, Mine D, Yamada Y, Eguchi K, Hanaoka H, Inomata T, Fukumoto Y, Yamamoto K, Tsutsui H, Masuyama T, Kitakaze M, Inoue T, Shimokawa H, Momomura S, Seino Y, Node K, On behalf of the HOMES-HF study investigators (2013) Home telemonitoring study for Japanese patients with heart failure (HOMES-HF): protocol for a multicentre randomised controlled trial. BMJ Open 3(6):e002972

    Article  PubMed  PubMed Central  Google Scholar 

  7. Brown S, Thorpe H, Hawkins K, Brown J (2005) Minimization–reducing predictability for multi-centre trials whilst retaining balance within centre. Stat Med 24:3715–3727

    Article  PubMed  Google Scholar 

  8. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198

    Article  PubMed  CAS  Google Scholar 

  9. Sakano Y, Tojyo M (1986) The General Self-Efficacy Scale (GSES): scale development and validation. Jap J Behav Ther 12:73–82

    Google Scholar 

  10. Rector TS (2005) A conceptual model of quality of life in relation to heart failure. J Card Fail 11:173–176

    Article  PubMed  Google Scholar 

  11. Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16:606–613

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Chaudhry SI, Phillips CO, Stewart SS, Riegel B, Mattera JA, Jerant AF, Krumholz HM (2007) Telemonitoring for patients with chronic heart failure: a systematic review. J Card Fail 13:56–62

    Article  PubMed  PubMed Central  Google Scholar 

  13. Klersy C, De Silvestri A, Gabutti G, Regoli F, Auricchio A (2009) A meta-analysis of remote monitoring of heart failure patients. J Am Coll Cardiol 54:1683–1694 (Erratum in: (2010) J Am Coll Cardiol 55:2185)

  14. Schoenfeld DA, Richter JR (1982) Nomograms for calculating the number of patients needed for a clinical trial with survival as an endpoint. Biometrics 38:163–170

    Article  PubMed  CAS  Google Scholar 

  15. Gooley TA, Leisenring W, Crowley J, Storer BE (1999) Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 18:695–706

    Article  PubMed  CAS  Google Scholar 

  16. Fine JP, Gray RJ (1999) A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 94:496–509

    Article  Google Scholar 

  17. Bakoyannis G, Touloumi G (2012) Practical methods for competing risks data: a review. Stat Methods Med Res 21:257–272

    Article  PubMed  Google Scholar 

  18. Satagopan JM, Ben-Porat L, Berwick M, Robson M, Kutler D, Auerbach AD (2004) A note on competing risks in survival data analysis. Br J Cancer 91:1229–1235

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Whellan DJ, Hasselblad V, Peterson E, O’Connor CM, Schulman KA (2005) Meta-analysis and review of heart failure disease management randomized controlled clinical trials. Am Heart J 149:722–729

    Article  PubMed  Google Scholar 

  20. Inglis SC, Clark RA, McAlister FA, Stewart S, Cleland JG (2011) Which components of heart failure programmes are effective? A systematic review and meta-analysis of the outcomes of structured telephone support or telemonitoring as the primary component of chronic heart failure management in 8323 patients: a bridged cochrane review. Eur J Heart Fail 13:1028–1040

    Article  PubMed  Google Scholar 

  21. Swedberg K, Wolf A, Ekman I (2011) Telemonitoring in patients with heart failure. N Engl J Med 364:1078 (author reply 1079–1080)

    Article  PubMed  CAS  Google Scholar 

  22. Walsh MN, Bove AA, Cross RR, Ferdinand KC, Forman DE, Freeman AM, Hughes S, Klodas E, Koplan M, Lewis WR, MacDonnell B, May DC, Messer JV, Pressler SJ, Sanz ML, Spertus JA, Spinler SA, Teichholz LE, Wong JB, Byrd KD, Drozda JP, Cacchione JG, Erb BD, Harrington RA, Kennett JD, Krumholz HM, Masoudi FA, Peterson ED, Poppas A, Sahn DJ, Sanz ML, Shahian DM, Windle JR, Wyman JF (2012) American College of Cardiology Foundation. ACCF 2012 health policy statement on patient-centered care in cardiovascular medicine: a report of the American College of Cardiology Foundation Clinical Quality Committee. J Am Coll Cardiol 59:2125–2143

    Article  PubMed  Google Scholar 

  23. Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383

    Article  PubMed  CAS  Google Scholar 

  24. Tsuchihashi M, Tsutsui H, Kodama K, Kasagi F, Takeshita A (2000) Clinical characteristics and prognosis of hospitalized patients with congestive heart failure, a study in Fukuoka, Japan. Jpn Circ J 64:953–959

    Article  PubMed  CAS  Google Scholar 

  25. Tsuchihashi-Makaya M, Hamaguchi S, Kinugawa S, Yokota T, Goto D, Yokoshiki H, Kato N, Takeshita A, Tsutsui H, For the JCARE-CARD Investigators (2009) Characteristics and outcomes of hospitalized patients with heart failure and reduced vs preserved ejection fraction. Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD). Circ J 73:1893–1900 (Erratum in: (2009) Circ J 73:2365)

  26. DeBusk RF, Miller NH, Parker KM, Bandura A, Kraemer HC, Cher DJ, West JA, Fowler MB, Greenwald G (2004) Care management for low-risk patients with heart failure: a randomized, controlled trial. Ann Intern Med 141:606–613

    Article  PubMed  Google Scholar 

  27. Goldberg LR, Piette JD, Walsh MN, Frank TA, Jaski BE, Smith AL, Rodriguez R, Mancini DM, Hopton LA, Orav EJ, Loh E, On behalf of the WHARF Investigators (2003) Randomized trial of a daily electronic home monitoring system in patients with advanced heart failure: the Weight Monitoring in Heart Failure (WHARF) trial. Am Heart J 146:705–712

    Article  PubMed  Google Scholar 

  28. Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM (1995) A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 333:1190–1195

    Article  PubMed  CAS  Google Scholar 

  29. Kahan BC, Cro S, Doré CJ, Bratton DJ, Rehal S, Maskell NA, Rahman N, Jairath V (2014) Reducing bias in open-label trials where blinded outcome assessment is not feasible: strategies from two randomised trials. Trials 15:456

    Article  PubMed  PubMed Central  Google Scholar 

  30. Frenneaux MP, Gollop ND, Loudon BL, Parasuraman S (2015) Remote monitoring in heart failure. Eur Heart J Qual Care Clin Outcomes 1:45–46

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge Tomoko Hirotaki, Miki Mori, Aya Yamada, Sae Katafuchi, and Junko Ishida for their valuable assistance. The members of HOMES-HF study investigators are Telemonitoring Center: Mika Nakamizo Chika Nishiyama, Kikumi Morita (Saga University). Independent Data Management Center: Yuko Horiuchi, Michiko Hanawa, Takako Kanai, and Hideki Hanaoka (Chiba University Hospital Clinical Research Center). Independent Endpoint Committee: Tohru Izumi (Kitasato University), Yoshihiko Saito (Nara Medical University), Yukihito Sato (Hyogo Prefectural Amagasaki Hospital). Local Investigators: Dokkyo Medical University Hospital, Tochigi (Haruyama A, Inami S, Nishi Y, Amano A, Arikawa T, Kikuchi M), Eto Clinic, Saga (Eto Y), Hiramatsu Hospital, Saga (Ishii K, Fukuda K, Soejima S), Hisano Clinic, Saga (Hisano R), Hokkaido University Hospital, Hokkaido (Goto D, Kinugawa S), Hyogo College of Medicine Hospital, Hyogo (Naito Y, Goda A, Iwasaku T, Eguchi A, Okuhara Y), Hyogo Prefectural Amagasaki Hospital, Hyogo (Taniguchi R, Takatsu Y, Washida K, Miyamoto T, Toma M, Yoshitani K, Fukuhara R, Fujiwara H), Imari Arita Kyoritsu Hospital, Saga (Matsunaga K), Jichi Medical University Hospital, Tochigi (Iwata T, Nishimura Y, Hoshide S, Shinpo M, Kario K), Katsuya Clinic, Hyogo (Katsuya T, Katsuya S), Kitasato University School of Medicine, Kanagawa (Naruke T, Kiryu M, Kurokawa S, Sato T, Koitabashi T), Koga Hospital 21, Fukuoka (Kajiwara M, Hiramatsu Y), Kyushu Kosei Nenkin Hospital, Fukuoka (Sedutsu Y, Hashimoto T, Yamamoto U, Miyata K, Mohri M, Yamamoto H, Origuchi H), National Cerebral and Cardiovascular Center Hospital, Osaka (Hasegawa T, Funada A, Takahama H, Ohara T, Kanzaki H, Asakura M, Noguchi T, Goto Y, Anzai T), Nippon Medical School Chiba-Hokusoh Hospital, Chiba (Ibuki C, Oba T, Takano M, Mitsunori Maruyama, Junko Abe, Daisuke Murakami, Ryo Munakata, Toru Inami, Nakamichi Kimata, Yamamoto T, Kurihara O), Oita University Hospital, Oita (Hara M, Nakagawa M, Yufu K, Sinohara T, Takahashi N, Saikawa T), Saga Prefectural Hospital Koseikan, Saga (Okahara A, Shirahama N, Koga Y, Nagamoto Y, Shiomi T, Yoshida K, Sadamatsu K), Saga University Hospital, Saga (Yoshioka G, Kakimoto Y, Uchino M, Tago M, Hiwatashi A, Kodama K, Sakamoto Y, Shimomura M, Sakuma M, Komatsu A, Yohisda K, Hikichi Y), Saiseikai Fukuoka General Hospital, Fukuoka (Hongo T, Natsuaki M), Saiseikai Karatsu Hospital, Saga (Sato A, Yazawa M, Tokushima T), Saitama Medical Center Jichi Medical University, Saitama (Hirahara T), Shimane University Hospital, Shimane (Watanabe N, Tanabe K, Ishibashi Y, Takahashi N, Endo A, Sugamori T, Kotani N, Sato H, Takeda M, Adachi T, Ito S, Ito S, Oshima T, Kawahara H, Paku M), St. Luke’s International Hospital, Tokyo (Nishi Y, Yamazoe M, Komatsu I, Niwa K), Tarumizu Municipal Medical Center, Tarumizu Chuo Hospital, Kagoshima (Iwatani N, Yamasuji K, Fukumoto N, Takenaka T, Abe S), Toho University Ohashi Medical Center, Tokyo (Noro M, Kujime S, Ito N, Enomoto Y), Tohoku University Hospital, Miyagi (Fukuda K, Takahashi J, Wakayama Y, Sugimura K, Matsumoto Y, Fukumoto Y), Tottori University Hospital, Tottori (Yanagihara K, Yamada K, Hirai M, Kato M).

Funding

The HOMES-HF study was supported by grants from the Japanese Ministry of Health, Labor, and Welfare Comprehensive Research on Aging and Health (KR23000003, KR24000001), and the Japan Society for the Promotion of Science KAKENHI Grant Number JP17K09510.

Author information

Authors and Affiliations

  1. Department of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, Saga, Saga, 849-8501, Japan

    Norihiko Kotooka, Machiko Asaka, Daisuke Nagatomo, Daigo Mine & Koichi Node

  2. Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Japan

    Masafumi Kitakaze

  3. Department of Clinical Research, Graduate School of Medicine, Chiba University, Chiba, Japan

    Kengo Nagashima & Yasunori Sato

  4. Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Tottori University, Yonago, Japan

    Yoshiharu Kinugasa & Kazuhiro Yamamoto

  5. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

    Kotaro Nochioka & Hiroaki Shimokawa

  6. Department of Cardiology, St. Luke’s International Hospital, Tokyo, Japan

    Atsushi Mizuno

  7. Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Omiya, Japan

    Yoko Yamada & Shin-ichi Momomura

  8. Koga Hospital 21, Kurume, Japan

    Akiko Kuratomi

  9. Department of Cardiology and Clinical Examination, Oita University, Oita, Japan

    Norihiro Okada

  10. Saiseikai Karatsu Hospital, Karatsu, Japan

    Daisuke Fujimatsu

  11. Tarumizu Municipal Medical Center, Tarumizu Chuo Hospital, Tarumizu, Japan

    So Kuwahata

  12. Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Japan

    Shigeru Toyoda & Teruo Inoue

  13. Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    Shin-ichi Hirotani & Tohru Masuyama

  14. Department of Medicine, Division of Cardiovascular Medicine, Jichi Medical University, Shimotsuke, Japan

    Takahiro Komori, Kazuo Eguchi & Kazuomi Kario

  15. Department of Cardiovascular Medicine, Kitasato Institute Hospital, Tokyo, Japan

    Takayuki Inomata

  16. Toho University Ohashi Medical Center, Tokyo, Japan

    Kaoru Sugi

  17. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Hiroyuki Tsutsui

  18. Department of Cardiology, Nippon Medical School Chiba-Hokusoh Hospital, Inzai, Japan

    Yoshihiko Seino

Authors
  1. Norihiko Kotooka
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. Masafumi Kitakaze
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. Kengo Nagashima
    View author publications

    You can also search for this author inPubMed Google Scholar

  4. Machiko Asaka
    View author publications

    You can also search for this author inPubMed Google Scholar

  5. Yoshiharu Kinugasa
    View author publications

    You can also search for this author inPubMed Google Scholar

  6. Kotaro Nochioka
    View author publications

    You can also search for this author inPubMed Google Scholar

  7. Atsushi Mizuno
    View author publications

    You can also search for this author inPubMed Google Scholar

  8. Daisuke Nagatomo
    View author publications

    You can also search for this author inPubMed Google Scholar

  9. Daigo Mine
    View author publications

    You can also search for this author inPubMed Google Scholar

  10. Yoko Yamada
    View author publications

    You can also search for this author inPubMed Google Scholar

  11. Akiko Kuratomi
    View author publications

    You can also search for this author inPubMed Google Scholar

  12. Norihiro Okada
    View author publications

    You can also search for this author inPubMed Google Scholar

  13. Daisuke Fujimatsu
    View author publications

    You can also search for this author inPubMed Google Scholar

  14. So Kuwahata
    View author publications

    You can also search for this author inPubMed Google Scholar

  15. Shigeru Toyoda
    View author publications

    You can also search for this author inPubMed Google Scholar

  16. Shin-ichi Hirotani
    View author publications

    You can also search for this author inPubMed Google Scholar

  17. Takahiro Komori
    View author publications

    You can also search for this author inPubMed Google Scholar

  18. Kazuo Eguchi
    View author publications

    You can also search for this author inPubMed Google Scholar

  19. Kazuomi Kario
    View author publications

    You can also search for this author inPubMed Google Scholar

  20. Takayuki Inomata
    View author publications

    You can also search for this author inPubMed Google Scholar

  21. Kaoru Sugi
    View author publications

    You can also search for this author inPubMed Google Scholar

  22. Kazuhiro Yamamoto
    View author publications

    You can also search for this author inPubMed Google Scholar

  23. Hiroyuki Tsutsui
    View author publications

    You can also search for this author inPubMed Google Scholar

  24. Tohru Masuyama
    View author publications

    You can also search for this author inPubMed Google Scholar

  25. Hiroaki Shimokawa
    View author publications

    You can also search for this author inPubMed Google Scholar

  26. Shin-ichi Momomura
    View author publications

    You can also search for this author inPubMed Google Scholar

  27. Yoshihiko Seino
    View author publications

    You can also search for this author inPubMed Google Scholar

  28. Yasunori Sato
    View author publications

    You can also search for this author inPubMed Google Scholar

  29. Teruo Inoue
    View author publications

    You can also search for this author inPubMed Google Scholar

  30. Koichi Node
    View author publications

    You can also search for this author inPubMed Google Scholar

Consortia

On behalf of the HOMES-HF study investigators

  • Mika Nakamizo
  • , Chika Nishiyama
  • , Kikumi Morita
  • , Yuko Horiuchi
  • , Michiko Hanawa
  • , Takako Kanai
  • , Hideki Hanaoka
  • , Tohru Izumi
  • , Yoshihiko Saito
  • , Yukihito Sato
  • , A. Haruyama
  • , S. Inami
  • , Y. Nishi
  • , A. Amano
  • , T. Arikawa
  • , M. Kikuchi
  • , Y. Eto
  • , K. Ishii
  • , K. Fukuda
  • , S. Soejima
  • , R. Hisano
  • , D. Goto
  • , S. Kinugawa
  • , Y. Naito
  • , A. Goda
  • , T. Iwasaku
  • , A. Eguchi
  • , Y. Okuhara
  • , R. Taniguchi
  • , Y. Takatsu
  • , K. Washida
  • , T. Miyamoto
  • , M. Toma
  • , K. Yoshitani
  • , R. Fukuhara
  • , H. Fujiwara
  • , K. Matsunaga
  • , T. Iwata
  • , Y. Nishimura
  • , S. Hoshide
  • , M. Shinpo
  • , K. Kario
  • , T. Katsuya
  • , S. Katsuya
  • , T. Naruke
  • , M. Kiryu
  • , S. Kurokawa
  • , T. Sato
  • , T. Koitabashi
  • , M. Kajiwara
  • , Y. Hiramatsu
  • , Y. Sedutsu
  • , T. Hashimoto
  • , U. Yamamoto
  • , K. Miyata
  • , M. Mohri
  • , H. Yamamoto
  • , H. Origuchi
  • , T. Hasegawa
  • , A. Funada
  • , H. Takahama
  • , T. Ohara
  • , H. Kanzaki
  • , M. Asakura
  • , T. Noguchi
  • , Y. Goto
  • , T. Anzai
  • , C. Ibuki
  • , T. Oba
  • , M. Takano
  • , Maruyama Mitsunori
  • , Abe Junko
  • , Murakami Daisuke
  • , Munakata Ryo
  • , Inami Toru
  • , Kimata Nakamichi
  • , T. Yamamoto
  • , O. Kurihara
  • , M. Hara
  • , M. Nakagawa
  • , K. Yufu
  • , T. Sinohara
  • , N. Takahashi
  • , T. Saikawa
  • , A. Okahara
  • , N. Shirahama
  • , Y. Koga
  • , Y. Nagamoto
  • , T. Shiomi
  • , K. Yoshida
  • , K. Sadamatsu
  • , G. Yoshioka
  • , Y. Kakimoto
  • , M. Uchino
  • , M. Tago
  • , A. Hiwatashi
  • , K. Kodama
  • , Y. Sakamoto
  • , M. Shimomura
  • , M. Sakuma
  • , A. Komatsu
  • , K. Yohisda
  • , Y. Hikichi
  • , T. Hongo
  • , M. Natsuaki
  • , A. Sato
  • , M. Yazawa
  • , T. Tokushima
  • , T. Hirahara
  • , N. Watanabe
  • , K. Tanabe
  • , Y. Ishibashi
  • , N. Takahashi
  • , A. Endo
  • , T. Sugamori
  • , N. Kotani
  • , H. Sato
  • , M. Takeda
  • , T. Adachi
  • , S. Ito
  • , S. Ito
  • , T. Oshima
  • , H. Kawahara
  • , M. Paku
  • , Y. Nishi
  • , M. Yamazoe
  • , I. Komatsu
  • , K. Niwa
  • , N. Iwatani
  • , K. Yamasuji
  • , N. Fukumoto
  • , T. Takenaka
  • , S. Abe
  • , M. Noro
  • , S. Kujime
  • , N. Ito
  • , Y. Enomoto
  • , K. Fukuda
  • , J. Takahashi
  • , Y. Wakayama
  • , K. Sugimura
  • , Y. Matsumoto
  • , Y. Fukumoto
  • , K. Yanagihara
  • , K. Yamada
  • , M. Hirai
  •  & M. Kato

Contributions

Study conception and design: NK, KK, TI, KS, KY, HT, TM, HS, SM, YS, YS, TI, and KN. Conducting the trial and acquisition of data: YK, KN, AM, DN, DM, MA, YY, AK, NO, DF, SK, ST, SH, TK, and KE. Statistical analysis: KN and YS. Drafting the article: NK, MA, KN, and YS. Revising the article: MK, TI, KN, SH, KN, KY, HT, YS, and KN. Final approval: all authors.

Corresponding author

Correspondence to Norihiko Kotooka.

Ethics declarations

Conflict of interest

Dr. Kotooka and Dr. Asaka have an endowed chair from Sumitomo Electric Industries Ltd., since 2014, and from Asahi Kasei Corporation since 2017. None of the authors has any relationship with industry or any financial associations within the past 2 years that might pose a conflict of interest in connection with the submitted article.

Additional information

The members of HOMES-HF study investigators are listed in “Acknowledgements”.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kotooka, N., Kitakaze, M., Nagashima, K. et al. The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF). Heart Vessels 33, 866–876 (2018). https://doi.org/10.1007/s00380-018-1133-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00380-018-1133-5

Keywords