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8-OH-DPAT enhances dopamine D2-induced maternal disruption in rats

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Abstract

Recent evidence indicates that 5-HT1A receptors play a significant role in mediating maternal behavior in rats. Given that they also modulate the mesocortical dopamine system, we hypothesized that 5-HT1A receptors may mediate maternal behavior, possibly by interacting with the D2 receptor. To address this issue, we used a combination of 5-HT1A agonist (8-OH-DPAT, 0.5 mg/kg) and two D2 drugs (an agonist quinpirole, QUIN, 1.0 mg/kg; a potent D2 antagonist haloperidol, HAL, 0.1 mg/kg) on rat maternal behavior in the home-cage maternal behavior and pup preference tests. We replicated the findings that acute QUIN, HAL, and 8-OH-DPAT disrupted home-cage maternal behavior. When administered in combination, pretreatment with HAL and QUIN worsened 8-OH-DPAT-induced maternal disruption and induced a decrease in the pup preference ratio. Accordingly, 8-OH-DPAT enhanced QUIN’ and HAL’s disruption of pup retrieval and pup preference, reversed the increase in hovering over pups induced by HAL. These findings suggest that activation of 5-HT1A receptors enhances D2-mediated maternal disruption. Furthermore, given that the combination of D2 drugs and 5-HT1A agonists only produced an additive effect on maternal disruption, 5-HT1A receptors may have a direct effect on maternal behavior independent of their interaction with D2 receptors.

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Abbreviations

QUIN:

Quinpirole

HAL:

Haloperidol

DA:

Dopamine

dBNST:

Dorsal part of the bed nucleus of the stria terminalis

DRN:

Dorsal raphe nucleus

mPFC:

Medial prefrontal cortex

EPM:

Elevated plus maze

PPI:

Prepulse inhibition

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Acknowledgements

This research was supported by a Grant from the National Natural Science Foundation of China (31900334), the Natural Science Foundation of Jiangsu Province (BK20190910), the Postdoctoral Science Foundation of China (2018M630610 and 2019T120468), the Science and Technology Innovation Cultivation Fund of Yangzhou University (2019CXJ151) and Innovation and Entrepreneurship Training Program for Students of Yangzhou University (X20200735).

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  1. Yongjian Cai and Xinyue Zhang contribute equally to this work.

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  1. Department of Animal Behavior, College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, 225009, Jiangsu, China

    Yongjian Cai, Xinyue Zhang, Tianyi Jiang, Haocheng Zhong, Xingchen Han, Rui Ma & Ruiyong Wu

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  1. Yongjian Cai
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Cai, Y., Zhang, X., Jiang, T. et al. 8-OH-DPAT enhances dopamine D2-induced maternal disruption in rats. J Comp Physiol A 208, 467–477 (2022). https://doi.org/10.1007/s00359-022-01551-4

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