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Stammzellbasierte Therapieansätze für retinale Erkrankungen

Stem cell-based therapies for retinal disorders

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Zusammenfassung

Im Rahmen zellbasierter Therapien für erbliche Netzhautdystrophien und verschiedene andere retinale Erkrankungen hat sich das Interesse zunehmend auf die therapeutischen Anwendungsmöglichkeiten von embryonalen und gewebespezifischen Stammzellen fokussiert. Stammzellen sind durch ihre Fähigkeit zur Selbsterneuerung und ihre Multipotenz charakterisiert. Aufgrund dieser Eigenschaften können sie in vitro vermehrt und potenziell in ganz bestimmte, „erwünschte“ Zelltypen differenziert werden. Stammzellen sind nicht nur Kandidatenzellen für die Entwicklung von Zellersatzstrategien, sondern auch interessante Zellen für den Aufbau von ex-vivo-Gentherapien. In diesem Artikel werden Experimente diskutiert, in denen das zelltherapeutische Potenzial von embryonalen, mesenchymalen, hämatopoetischen, neuralen und retinalen Stammzellen für die Behandlung hereditärer Netzhautdystrophien und verschiedener anderer retinaler Erkrankungen untersucht wurde.

Abstract

In the context of cell-based therapies for hereditary retinal dystrophies and other retinal disorders, interest has focussed on the therapeutic potential of embryonic and tissue-specific stem cells. Stem cells are characterised by their capacity for self-renewal and by their multipotentiality. Because of these properties, they can be expanded in vitro and eventually differentiated into “desired” specialized cell types. Stem cells are not only candidate cells for the development of cell replacement strategies, but are also interesting cells for the establishment of ex vivo gene therapies. Here, we discuss recent experimental work performed to evaluate the therapeutic potential of embryonic, mesenchymal, hematopoietic, neural and retinal stem cells for the treatment of inherited retinal dystrophies and other retinal diseases.

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Authors and Affiliations

  1. Transplantationslabor des Kopf- und Hautzentrums, Klinik und Poliklinik für Augenheilkunde des Universitätsklinikums Hamburg-Eppendorf, Hamburg, Germany

    U. Bartsch, S. J. Linke & B. Petrowitz

  2. Transplantationslabor, Klinik und Poliklinik für Augenheilkunde des Universitätsklinikums Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    U. Bartsch

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  1. U. Bartsch
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Correspondence to U. Bartsch.

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Gefördert durch das Bundesministerium für Bildung und Forschung (01GN0126) und die Ernst und Claere Jung S.jpgtung.

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Bartsch, U., Linke, S.J. & Petrowitz, B. Stammzellbasierte Therapieansätze für retinale Erkrankungen. Ophthalmologe 102, 679–687 (2005). https://doi.org/10.1007/s00347-005-1188-4

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