Abstract
Purpose
To report long-term oncologic and functional outcomes of a large consecutive single center series of Robot-assisted radical cystectomy (RARC)- intracorporeal (IC) Urinary Diversion (UD), identifying their predicting factors.
Methods
A single center Bladder cancer (BC) database was queried for “RARC” and “ICUD”, including patients treated between January 2012 and September 2020. Kaplan–Meier curves were assessed disease-free (DFS), cancer-specific (CSS) and overall survival (OS) probability. Univariable (UV) and multivariable (MV) analysis were adopted to identify predictors of DFS, CSS and OS. Kaplan–Meier method evaluated day- and night-time continence recovery probabilities; UV and MV analysis were adopted to identify predictors of Day-time continence.
Results
Overall, 251 patients were included. Among them, 192 patients underwent intracorporeal ileal orthotopic neobladder (ION) (76.5%). Five-year DFS, CSS and OS rates were 66.5%, 65.4% and 61.5%; pT stage ≥ 3 and pathologic nodal involvement were identified as negative independent predictors of DFS (HR 2.39, p = 0.001, HR 4.64, p ≤ 0.001), CSS (HR 2.20, p = 0.01, HR 3.97, p < 0.001) and OS (HR 2.25, p = 0.005, HR 3.95, p < 0.001). In RARC-ION patients, Trifecta rate was 64.1%. One-year day- and night-time continence rates were 78.6% and 48.3%. Age (HR 0.98, p = 0.03), female gender (HR 0.57, p = 0.008) and complications Clavien grade ≥ 3 (HR 0.55, p = 0.03) were identified as independent predictors of day-time incontinence.
Conclusions
Long-term oncologic outcomes and their predicting factors seem aligned to the largest historical open series and multi-institutional robotic series data. According to the identified predicting factors undermining a proper achievement of day-time continence, this represents an objective support, in order to properly advice specific sub-group of patients.
Similar content being viewed by others
References
Witjes JA, Bruins HM, Cathomas R et al (2021) European Association of Urology Guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines. Eur Urol 79:82–104. https://doi.org/10.1016/j.eururo.2020.03.055
Bochner BH, Dalbagni G, Marzouk KH et al (2018) Randomized trial comparing open radical cystectomy and robot-assisted laparoscopic radical cystectomy: oncologic outcomes. Eur Urol 74:465–471. https://doi.org/10.1016/j.eururo.2018.04.030
Simone G, Tuderti G, Misuraca L et al (2018) Perioperative and mid-term oncologic outcomes of robotic assisted radical cystectomy with totally intracorporeal neobladder: results of a propensity score matched comparison with open cohort from a single-centre series. Eur J Surg Oncol 44:1432–1438. https://doi.org/10.1016/j.ejso.2018.04.006
Parekh DJ, Reis IM, Castle EP et al (2018) Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial. Lancet 391:2525–2536. https://doi.org/10.1016/S0140-6736(18)30996-6
Brassetti A, Cacciamani G, Anceschi U et al (2020) Long-term oncologic outcomes of robot-assisted radical cystectomy (RARC) with totally intracorporeal urinary diversion (ICUD): a multi-center study. World J Urol 38:837–843. https://doi.org/10.1007/s00345-019-02842-3
Cacciamani GE, Rajarubendra N, Artibani W, Gill IS (2019) Robotic intracorporeal urinary diversion: state of the art. Curr Opin Urol 29:293–300. https://doi.org/10.1097/MOU.0000000000000592
Tuderti G, Mastroianni R, Brassetti A et al (2021) Robot-assisted radical cystectomy with intracorporeal neobladder: impact of learning curve and long-term assessment of functional outcomes. Minerva Urol Nephrol 73:754–762. https://doi.org/10.23736/S2724-6051.20.03948-X
Simone G, Papalia R, Misuraca L et al (2018) Robotic intracorporeal Padua ileal bladder: surgical technique, perioperative, oncologic and functional outcomes. Eur Urol 73:934–940. https://doi.org/10.1016/j.eururo.2016.10.018
Claroni C, Covotta M, Torregiani G et al (2019) Recovery from anesthesia after robotic-assisted radical cystectomy: two different reversals of neuromuscular blockade. J Clin Med 8:1774. https://doi.org/10.3390/jcm8111774
Brassetti A, Tuderti G, Anceschi U et al (2019) Combined reporting of surgical quality, cancer control and functional outcomes of robot-assisted radical cystectomy with intracorporeal orthotopic neobladder into a novel trifecta. Minerva Urol Nefrol 71:590–596. https://doi.org/10.23736/S0393-2249.19.03566-5
Levey AS, Bosch JP, Lewis JB et al (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461–470. https://doi.org/10.7326/0003-4819-130-6-199903160-00002
Levey AS, Eckardt K-U, Tsukamoto Y et al (2005) Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 67:2089–2100. https://doi.org/10.1111/j.1523-1755.2005.00365.x
Yuh B, Wilson T, Bochner B et al (2015) Systematic review and cumulative analysis of oncologic and functional outcomes after robot-assisted radical cystectomy. Eur Urol 67:402–422. https://doi.org/10.1016/j.eururo.2014.12.008
Desai MM, Gill IS, de Castro Abreu AL et al (2014) Robotic intracorporeal orthotopic neobladder during radical cystectomy in 132 patients. J Urol 192:1734–1740. https://doi.org/10.1016/j.juro.2014.06.087
Presicce F, Leonardo C, Tuderti G et al (2021) Late complications of robot-assisted radical cystectomy with totally intracorporeal urinary diversion. World J Urol 39:1903–1909. https://doi.org/10.1007/s00345-020-03378-7
Tuderti G, Brassetti A, Minisola F et al (2019) Transnephrostomic indocyanine green-guided robotic ureteral reimplantation for benign ureteroileal strictures after robotic cystectomy and intracorporeal neobladder: step-by-step surgical technique, perioperative and functional outcomes. J Endourol 33:823–828. https://doi.org/10.1089/end.2019.0376
Ghodoussipour S, Ahmadi N, Goh A et al (2022) Robotic repair of ureteroenteric stricture following radical cystectomy: a multi-institutional experience. Urology 161:125–130. https://doi.org/10.1016/j.urology.2021.11.020
Raza SJ, Wilson T, Peabody JO et al (2015) Long-term oncologic outcomes following robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium. Eur Urol 68:721–728. https://doi.org/10.1016/j.eururo.2015.04.021
Benamran D, Phé V, Drouin SJ et al (2020) Functional outcomes obtained with intracorporeal neobladder after robotic radical cystectomy for cancer: a narrative review. J Robot Surg 14:813–820. https://doi.org/10.1007/s11701-020-01070-x
Desai MM, Gill IS (2015) “The devil is in the details”: randomized trial of robotic versus open radical cystectomy. Eur Urol 67:1053–1055. https://doi.org/10.1016/j.eururo.2015.01.017
Anceschi U, Maida DIF, Flammia RS et al (2022) Robotic intracorporeal Padua ileal neobladder vs. Florin pouch: comparison of mid-term urodynamic and functional profiles. Minerva Urol Nephrol 74:825–827. https://doi.org/10.23736/S2724-6051.22.04884-4
Di Maida F, Grosso AA, Tasso G et al (2022) Robot assisted radical cystectomy with Florence Robotic Intracorporeal Neobladder (FloRIN): functional and urodynamic features compared with a contemporary series of open Vescica Ileale Padovana (VIP). Eur J Surg Oncol 48:1854–1861. https://doi.org/10.1016/j.ejso.2022.04.007
Tuderti G, Mastroianni R, Flammia S et al (2020) Sex-sparing robot-assisted radical cystectomy with intracorporeal Padua ileal neobladder in female: surgical technique, perioperative, oncologic and functional outcomes. J Clin Med 9:577. https://doi.org/10.3390/jcm9020577
Mastroianni R, Ferriero M, Tuderti G et al (2022) Open radical cystectomy versus robot-assisted radical cystectomy with intracorporeal urinary diversion: early outcomes of a single-center randomized controlled trial. J Urol 207:982–992. https://doi.org/10.1097/JU.0000000000002422
Mastroianni R, Tuderti G, Anceschi U et al (2022) Comparison of patient-reported health-related quality of life between open radical cystectomy and robot-assisted radical cystectomy with intracorporeal urinary diversion: interim analysis of a randomised controlled trial. Eur Urol Focus 8:465–471. https://doi.org/10.1016/j.euf.2021.03.002
Mastroianni R, Tuderti G, Ferriero M et al (2023) Open vs robotic intracorporeal Padua ileal bladder: functional outcomes of a single-centre RCT. World J Urol 41:739–746. https://doi.org/10.1007/s00345-023-04312-3
Hautmann RE, Volkmer BG, Schumacher MC et al (2006) Long-term results of standard procedures in urology: the ileal neobladder. World J Urol 24:305–314. https://doi.org/10.1007/s00345-006-0105-z
Hautmann RE, Abol-Enein H, Davidsson T et al (2013) ICUD-EAU international consultation on bladder cancer 2012: urinary diversion. Eur Urol 63:67–80. https://doi.org/10.1016/j.eururo.2012.08.050
Lombardo R, Mastroianni R, Tuderti G et al (2021) Benchmarking PASADENA consensus along the learning curve of robotic radical cystectomy with intracorporeal neobladder: CUSUM based assessment. J Clin Med 10:5969. https://doi.org/10.3390/jcm10245969
Funding
The authors did not receive support from any organization for the submitted work. -The authors have no relevant financial or non-financial interests to disclose.
Author information
Authors and Affiliations
Contributions
TG contributed to project development, data analysis, manuscript writing. MR contributed to data collection. CG contributed to data collection. AU contributed to data collection. Bove AM contributed to data collection. BA contributed to data collection. FM contributed to data collection. ML: contributed to data collection. FRS contributed to data collection. PF contributed to data collection. D’AS contributed to data collection. Leonardo C contributed to data collection. GS contributed to data collection. AM contributed to data collection. ZA contributed to data collection. GAB contributed to data collection. TG contributed to data collection. GM contributed to manuscript editing, supervision. SG contributed to project development, data analysis, manuscript editing, supervision.
Corresponding author
Ethics declarations
Conflict of interest
We have nothing to disclose.
Human and animal rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Tuderti, G., Mastroianni, R., Chiacchio, G. et al. Long-term oncologic and functional outcomes following robot-assisted radical cystectomy and intracorporeal Padua ileal bladder: results from a single high-volume center. World J Urol 41, 2359–2366 (2023). https://doi.org/10.1007/s00345-023-04523-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00345-023-04523-8