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Health-related quality of life (HRQoL), anxiety and depression in patients with ureteral stricture: a multi-institutional study

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Abstract

Purpose

To evaluate health-related quality of life (HRQoL), anxiety and depression levels in patients with ureteral stricture (US) and to further investigate factors independently affecting this.

Methods

We prospectively recruited a cohort of 275 consecutive patients with US between June 2020 and April 2021. The participants were required to provide complete sociodemographic, clinical and pathologic information. All patients were administered questionnaires to evaluate HRQoL, anxiety and depression. Multivariate linear regression analyses were performed to assess the contribution of covariates on HRQoL, anxiety and depression.

Results

Patients with US, particularly iatrogenic US, scored significantly lower than the Chinese general population in all domains of the SF-36 (all p < 0.001), except SF. Increased age, female and high education attainment were independently associated with poor HRQoL. Interestingly, iatrogenic US, nephrostomy tube placement, urinary symptoms, high anxiety and depression level independently predicted poor HRQoL. Furthermore, the percentages of anxiety and depression cases in patients with US were 31.3% and 20.7%, respectively. Iatrogenic US and urinary symptoms, specifically waist discomfort, were the strongest predictors of increased levels of anxiety and depression.

Conclusion

Patients with US exhibited poor quality of life and emotional status. Various factors independently predicted worse HRQoL and emotion, which provide potential targets for medical, lifestyle-related, psychological interventions.

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Data availability

The data that support the findings of this study are available from the corresponding author, upon reasonable request.

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Funding

This study was supported by grants from the National High Level Hospital Clinical Research Funding (Scientific Research Seed Fund of Peking University First Hospital) (2022SF78).

Author information

Author notes

  1. Zhihua Li, Xiang Wang and Yicen Ying contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China

    Zhihua Li, Xiang Wang, Yicen Ying, Xinfei Li, Weijie Zhu, Chang Meng, Guanpeng Han, Jie Wang, Yanbo Huang, Kunlin Yang, Hua Guan, Xuesong Li & Liqun Zhou

  2. Department of Nursing, Peking University First Hospital, Peking University, No. 8 Xishiku St, Xicheng District, Beijing, 100034, China

    Zhihua Li, Yanbo Huang & Hua Guan

  3. Department of Urology, Emergency General Hospital, No. 29 Xibahenanli St, Chaoyang District, Beijing, 100020, China

    Peng Zhang

  4. Department of Urology, Beijing Jiangong Hospital, No. 6 Rufuli St, Xicheng District, Beijing, 100034, China

    Jing Liu & Hongjian Zhu

Authors
  1. Zhihua Li
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  2. Xiang Wang
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  3. Yicen Ying
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  4. Xinfei Li
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  6. Chang Meng
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  7. Guanpeng Han
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  9. Jie Wang
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  11. Kunlin Yang
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  12. Peng Zhang
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  13. Hongjian Zhu
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  14. Hua Guan
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  15. Xuesong Li
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Correspondence to Xuesong Li.

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Li, Z., Wang, X., Ying, Y. et al. Health-related quality of life (HRQoL), anxiety and depression in patients with ureteral stricture: a multi-institutional study. World J Urol 41, 275–281 (2023). https://doi.org/10.1007/s00345-022-04227-5

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  • DOI: https://doi.org/10.1007/s00345-022-04227-5

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