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Reasons to go for thulium-based anatomical endoscopic enucleation of the prostate

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Abstract

Purpose

To summarize the current evidence and the reasons to go for thulium-based anatomical endoscopic enucleation of the prostate (AEEP).

Methods

This review discusses the available literature on thulium-based AEEP.

Results

Thulium lasers operate at a wavelength between 1940 and 2013 nm. This wavelength, which has a low penetration depth in water, allows to perform smooth cuts in the prostatic tissue and allows urologists to perform various procedures: resection, vaporization, enucleation, or vapoenucleation of the prostate. Depending on the type of thulium laser, it can be used either in a continuous, or pulsed mode.

Conclusion

In recent years, an increasing amount of evidence has described the thulium laser as a minimally invasive and size-independent treatment option for benign prostatic enlargement with excellent long-term results.

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References

  1. Herrmann TRW (2016) Enucleation is enucleation is enucleation is enucleation. World J Urol 34:1353–1355. https://doi.org/10.1007/s00345-016-1922-3

    Article  PubMed  Google Scholar 

  2. Bach T, Muschter R, Sroka R et al (2012) Laser treatment of benign prostatic obstruction: basics and physical differences. EurUrol 61:317–325. https://doi.org/10.1016/j.eururo.2011.10.009

    Article  Google Scholar 

  3. Xia S, Zhang Y, Lu J et al (2005) Thulium laser resection of prostate-tangerine technique in treatment of benign prostate hyperplasia. Zhonghua Yi Xue Za Zhi 85:3225–3228

    PubMed  Google Scholar 

  4. Bach T, Wendt-Nordahl G, Michel MS et al (2009) Feasibility and efficacy of Thulium:YAG laser enucleation (VapoEnucleation) of the prostate. World J Urol 27:541–545. https://doi.org/10.1007/s00345-008-0370-0

    Article  CAS  PubMed  Google Scholar 

  5. Herrmann TRW, Bach T, Imkamp F et al (2010) Thulium laser enucleation of the prostate (ThuLEP): transurethral anatomical prostatectomy with laser support. Introduction of a novel technique for the treatment of benign prostatic obstruction. World J Urol 28:45–51. https://doi.org/10.1007/s00345-009-0503-0

    Article  PubMed  Google Scholar 

  6. Vargas C, García-Larrosa A, Capdevila S, Laborda A (2014) Vaporization of the prostate with 150-w thulium laser: complications with 6-month follow-up. J Endourol 28:841–845. https://doi.org/10.1089/end.2013.0715

    Article  PubMed  PubMed Central  Google Scholar 

  7. Becker B, Herrmann TRW, Gross AJ, Netsch C (2018) Thulium vapoenucleation of the prostate versus holmium laser enucleation of the prostate for the treatment of large volume prostates: preliminary 6-month safety and efficacy results of a prospective randomized trial. World J Urol 36:1663–1671. https://doi.org/10.1007/s00345-018-2321-8

    Article  CAS  PubMed  Google Scholar 

  8. Bach T, Xia SJ, Yang Y et al (2010) Thulium: YAG 2 mum cw laser prostatectomy: where do we stand? World J Urol 28:163–168. https://doi.org/10.1007/s00345-010-0522-x

    Article  CAS  PubMed  Google Scholar 

  9. Netsch C, Bach T, Herrmann TRW et al (2013) Evaluation of the learning curve for Thulium VapoEnucleation of the prostate (ThuVEP) using a mentor-based approach. World J Urol 31:1231–1238. https://doi.org/10.1007/s00345-012-0894-1

    Article  CAS  PubMed  Google Scholar 

  10. Bach T, Netsch C, Pohlmann L et al (2011) Thulium:YAGvapoenucleation in large volume prostates. J Urol 186:2323–2327. https://doi.org/10.1016/j.juro.2011.07.073

    Article  PubMed  Google Scholar 

  11. Netsch C, Stoehrer M, Brüning M et al (2014) Safety and effectiveness of Thulium VapoEnucleation of the prostate (ThuVEP) in patients on anticoagulant therapy. World J Urol 32:165–172. https://doi.org/10.1007/s00345-013-1093-4

    Article  CAS  PubMed  Google Scholar 

  12. Becker B, Orywal AK, Gross AJ, Netsch C (2019) Thulium vapoenucleation of the prostate (ThuVEP) for prostates larger than 85 ml: long-term durability of the procedure. Lasers Med Sci 34:1637–1643. https://doi.org/10.1007/s10103-019-02760-1

    Article  PubMed  Google Scholar 

  13. Enikeev D, Okhunov Z, Rapoport L et al (2018) Novel thulium fiber laser for enucleation of prostate: a retrospective comparison with open simple prostatectomy. J Endourol 33:16–21. https://doi.org/10.1089/end.2018.0791

    Article  Google Scholar 

  14. Taratkin M, Netsch C, Enikeev D et al (2020) The impact of the laser fiber-tissue distance on histological parameters in a porcine kidney model. World J Urol. https://doi.org/10.1007/s00345-020-03326-5

    Article  PubMed  Google Scholar 

  15. Becker B, Enikeev D, Netsch C et al (2020) Comparative analysis of vaporization and coagulation properties of a hybrid laser (combination of a thulium and blue diode laser) vs thulium and Ho:YAG lasers: potential applications in endoscopic enucleation of the prostate. J Endourol 34:862–867. https://doi.org/10.1089/end.2020.0009

    Article  PubMed  Google Scholar 

  16. Netsch C, Gross AJ, Herrmann TRW, Becker B (2020) Current use of thulium lasers in endourology and future perspectives. Arch EspUrol 73:682–688

    Google Scholar 

  17. Carmignani L, Picozzi S, Casellato S et al (2013) 2174 thulium laser enucleation of the prostate versus transvesical open enucleation for prostate adenoma: a randomized prospective trial. J Urol. https://doi.org/10.1016/j.juro.2013.02.2083

    Article  PubMed  Google Scholar 

  18. Świniarski PP, Stępień S, Dudzic W et al (2012) BPH Thulium laser enucleation of the prostate (TmLEP) vs. transurethral resection of the prostate (TURP): evaluation of early results. cejurol3/2012 65:130–134. https://doi.org/10.5173/ceju.2012.03.art6

    Article  Google Scholar 

  19. Chang C-H, Lin T-P, Chang Y-H et al (2015) Vapoenucleation of the prostate using a high-power thulium laser: a one-year follow-up study. BMC Urol 15:40. https://doi.org/10.1186/s12894-015-0032-7

    Article  PubMed  PubMed Central  Google Scholar 

  20. Enikeev D, Netsch C, Rapoport L et al (2019) Novel thulium fiber laser for endoscopic enucleation of the prostate: a prospective comparison with conventional transurethral resection of the prostate. Int J Urol 26:1138–1143. https://doi.org/10.1111/iju.14115

    Article  CAS  PubMed  Google Scholar 

  21. Hou C-P, Lin Y-H, Juang H-H et al (2020) Clinical outcome of transurethral enucleation of the prostate using the 120-W thulium Laser (VelaTM XL) compared to bipolar transurethral resection of the prostate (TURP) in aging male. J Aging 12:1888–1898. https://doi.org/10.18632/aging.102720

    Article  CAS  Google Scholar 

  22. Yang Z, Wang X, Liu T (2013) Thulium laser enucleation versus plasmakinetic resection of the prostate: a randomized prospective trial with 18-month follow-up. Urology 81:396–400. https://doi.org/10.1016/j.urology.2012.08.069

    Article  PubMed  Google Scholar 

  23. Yuan R, Boyu Y, Fujun Z et al (2019) Transurethral thulium laser enucleation versus resection of the prostate for treating benign prostatic hyperplasia: a retrospective study. Lasers Med Sci 34:329–334. https://doi.org/10.1007/s10103-018-2597-3

    Article  PubMed  Google Scholar 

  24. Sun Q, Guo W, Cui D et al (2019) Thulium laser enucleation versus thulium laser resection of the prostate for prevention of bladder neck contracture in a small prostate: a prospective randomized trial. World J Urol 37:853–859. https://doi.org/10.1007/s00345-018-2463-8

    Article  PubMed  Google Scholar 

  25. Netsch C, Magno C, Butticè S et al (2016) Thulium vaporesection of the prostate and thulium vapoenucleation of the prostate in patients on oral anticoagulants: a retrospective three-centre matched-paired comparison. UrolInt 96:421–426. https://doi.org/10.1159/000441013

    Article  CAS  Google Scholar 

  26. Chung JS, Kang PM, Seo WI et al (2014) Thulium laser (RevoLix) vaporesection versus vapoenucleation with morcellator (Piranha) for the treatment of benign prostatic obstruction: a propensity-matched multicenter analysis: Thulium vaporesection or vaponucleation. Int J Urol 21:1156–1161. https://doi.org/10.1111/iju.12547

    Article  PubMed  Google Scholar 

  27. Xiao K-W, Zhou L, He Q et al (2019) Enucleation of the prostate for benign prostatic hyperplasia thulium laser versus holmium laser: a systematic review and meta-analysis. Lasers Med Sci 34:815–826. https://doi.org/10.1007/s10103-018-02697-x

    Article  PubMed  Google Scholar 

  28. Bozzini G, Berti L, Aydoğan TB et al (2020) A prospective multicenter randomized comparison between holmium laser enucleation of the prostate (HoLEP) and thulium laser enucleation of the prostate (ThuLEP). World J Urol. https://doi.org/10.1007/s00345-020-03468-6

    Article  PubMed  Google Scholar 

  29. Hueber P-A, Ben-Zvi T, Liberman D et al (2012) Mid term outcomes of initial 250 case experience with GreenLight 120W-HPS photoselective vaporization prostatectomy for benign prostatic hyperplasia: comparison of prostate volumes < 60 cc, 60 cc-100 cc and > 100 cc. Can J Urol 19:6450–6458

    PubMed  Google Scholar 

  30. Mamoulakis C, Efthimiou I, Kazoulis S et al (2011) The modified Clavien classification system: a standardized platform for reporting complications in transurethral resection of the prostate. World J Urol 29:205–210. https://doi.org/10.1007/s00345-010-0566-y

    Article  PubMed  Google Scholar 

  31. Netsch C, Tiburtius C, Bach T et al (2014) Association of prostate size and perioperative morbidity in Thulium:YAGvapoenucleation of the prostate. UrolInt 93:22–28. https://doi.org/10.1159/000355105

    Article  CAS  Google Scholar 

  32. Pearce SM, Pariser JJ, Malik RD et al (2016) Outcomes following Thulium vapoenucleation of large prostates. IntBraz J Urol 42:757–765

    Google Scholar 

  33. Chang C-H, Lin T-P, Huang J-Y (2019) Safety and effectiveness of high-power thulium laser enucleation of the prostate in patients with glands larger than 80 mL. BMC Urol 19:8. https://doi.org/10.1186/s12894-019-0437-9

    Article  PubMed  PubMed Central  Google Scholar 

  34. Rivera M, Krambeck A, Lingeman J (2017) Holmium laser enucleation of the prostate in patients requiring anticoagulation. CurrUrol Rep 18:77. https://doi.org/10.1007/s11934-017-0727-2

    Article  Google Scholar 

  35. Castellani D, Pirola GM, Gasparri L et al (2019) Are Outcomes of thulium laser enucleation of the prostate different in men aged 75 and over? A propensity score analysis. Urology 132:170–176. https://doi.org/10.1016/j.urology.2019.06.025

    Article  PubMed  Google Scholar 

  36. Hou C-M, Chen C-L, Lin Y-H et al (2016) Treatment outcomes of benign prostate hyperplasia by thulium vapoenucleation of the prostate in aging men. UrolSci 27:230–233. https://doi.org/10.1016/j.urols.2016.03.006

    Article  Google Scholar 

  37. Rausch S, Heider T, Bedke J et al (2015) Analysis of early morbidity and functional outcome of thulium: yttrium-aluminum-garnet laser enucleation for benign prostate enlargement: patient age and prostate size determine adverse surgical outcome. Urology 85:182–188. https://doi.org/10.1016/j.urology.2014.10.002

    Article  PubMed  Google Scholar 

  38. Bozzini G, Berti L, Maltagliati M et al (2020) Ejaculation-sparing thulium laser enucleation of the prostate (ES-ThuLEP): outcomes on a large cohort. World J Urol. https://doi.org/10.1007/s00345-020-03442-2

    Article  PubMed  Google Scholar 

  39. Kim M, Song SH, Ku JH et al (2015) Pilot study of the clinical efficacy of ejaculatory hood sparing technique for ejaculation preservation in Holmium laser enucleation of the prostate. Int J Impot Res 27:20–24. https://doi.org/10.1038/ijir.2014.22

    Article  CAS  PubMed  Google Scholar 

  40. Wang Y, Shao J, Lu Y et al (2014) Impact of 120-W 2-μm continuous wave laser vapoenucleation of the prostate on sexual function. Lasers Med Sci 29:689–693. https://doi.org/10.1007/s10103-013-1386-2

    Article  PubMed  Google Scholar 

  41. Tiburtius C, Knipper S, Gross AJ, Netsch C (2014) Impact of thulium VapoEnucleation of the prostate on erectile function: a prospective analysis of 72 patients at 12-month follow-up. Urology 83:175–180. https://doi.org/10.1016/j.urology.2013.08.029

    Article  PubMed  Google Scholar 

  42. Saredi G, Pacchetti A, Pirola GM et al (2016) Impact of thulium laser enucleation of the prostate on erectile, ejaculatory and urinary functions. UrolInt 97:397–401. https://doi.org/10.1159/000446829

    Article  Google Scholar 

  43. Iacono F, Prezioso D, Di Lauro G et al (2012) Efficacy and safety profile of a novel technique, ThuLEP (Thulium laser enucleation of the prostate) for the treatment of benign prostate hypertrophy. Our experience on 148 patients. BMC Surg 12(Suppl 1):S21. https://doi.org/10.1186/1471-2482-12-S1-S21

    Article  PubMed  PubMed Central  Google Scholar 

  44. Enikeev D, Glybochko P, Rapoport L et al (2018) Impact of endoscopic enucleation of the prostate with thulium fiber laser on the erectile function. BMC Urol 18:87. https://doi.org/10.1186/s12894-018-0400-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Carmignani L, Bozzini G, Macchi A et al (2014) Sexual outcome of patients undergoing thulium laser enucleation (ThuLEP) for BPH. Asian J Androl. https://doi.org/10.4103/1008-682X.139255

    Article  Google Scholar 

  46. Mebust WK, Holtgrewe HL, Cockett ATK, Peters PC (2002) Transurethral prostatectomy: immediate and postoperative complications. A cooperative study of 13 participating institutions evaluating 3,885 patients. 1989. J Urol 167:999–1003

    Article  CAS  PubMed  Google Scholar 

  47. Oelke M, Bachmann A, Descazeaud A et al (2013) EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. EurUrol 64:118–140. https://doi.org/10.1016/j.eururo.2013.03.004

    Article  Google Scholar 

  48. Hauser S, Rogenhofer S, Ellinger J et al (2012) Thulium laser (Revolix) vapoenucleation of the prostate is a safe procedure in patients with an increased risk of hemorrhage. UrolInt 88:390–394. https://doi.org/10.1159/000336874

    Article  Google Scholar 

  49. Castellani D, Di Rosa M, Gasparri L et al (2020) Thulium laser vapoenucleation of the prostate (ThuVEP) in men at high cardiovascular risk and on antithrombotic therapy: a single-center experience. J Clin Med. https://doi.org/10.3390/jcm9040917

    Article  PubMed  PubMed Central  Google Scholar 

  50. Becker B, Netsch C, Hansen J et al (2019) Perioperative safety in patient under oral anticoagulation during holmium laser enucleation of the prostate. J Endourol 33:219–224. https://doi.org/10.1089/end.2018.0693

    Article  PubMed  Google Scholar 

  51. Gross AJ, Netsch C, Knipper S et al (2013) Complications and early postoperative outcome in 1080 patients after thulium vapoenucleation of the prostate: results at a single institution. EurUrol 63:859–867. https://doi.org/10.1016/j.eururo.2012.11.048

    Article  Google Scholar 

  52. Saredi G, Pirola GM, Pacchetti A et al (2015) Evaluation of the learning curve for thulium laser enucleation of the prostate with the aid of a simulator tool but without tutoring: comparison of two surgeons with different levels of endoscopic experience. BMC Urol 15:49. https://doi.org/10.1186/s12894-015-0045-2

    Article  PubMed  PubMed Central  Google Scholar 

  53. Krombach P, Ritter M, Häcker A (2013) 2177 learning curve in thulium enucleation of the prosTATE. J Urol. https://doi.org/10.1016/j.juro.2013.02.2086

    Article  Google Scholar 

  54. Kampantais S, Dimopoulos P, Tasleem A et al (2018) Assessing the learning curve of holmium laser enucleation of prostate (HoLEP). A Systematic Review Urology 120:9–22. https://doi.org/10.1016/j.urology.2018.06.012

    Article  PubMed  Google Scholar 

  55. Enikeev D, Glybochko P, Rapoport L et al (2018) A randomized trial comparing the learning curve of 3 endoscopic enucleation techniques (HoLEP, ThuFLEP, and MEP) for BPH using mentoring approach-initial results. Urology 121:51–57. https://doi.org/10.1016/j.urology.2018.06.045

    Article  PubMed  Google Scholar 

  56. Becker B, Enikeev D, Glybochko P et al (2019) Effect of optical fiber diameter and laser emission mode (cw vs pulse) on tissue damage profile using 1.94 µm Tm:fiber lasers in a porcine kidney model. World J Urol. https://doi.org/10.1007/s00345-019-02944-y

    Article  PubMed  PubMed Central  Google Scholar 

  57. Enikeev D, Morozov A, Taratkin M et al (2020) Systematic review of the endoscopic enucleation of the prostate learning curve. World J Urol. https://doi.org/10.1007/s00345-020-03451-1

    Article  PubMed  PubMed Central  Google Scholar 

  58. Robert G, Cornu J-N, Fourmarier M et al (2016) Multicentre prospective evaluation of the learning curve of holmium laser enucleation of the prostate (HoLEP). BJU Int 117:495–499. https://doi.org/10.1111/bju.13124

    Article  PubMed  Google Scholar 

  59. Peyronnet B, Robert G, Comat V et al (2017) Learning curves and perioperative outcomes after endoscopic enucleation of the prostate: a comparison between GreenLight 532-nm and holmium lasers. World J Urol 35:973–983. https://doi.org/10.1007/s00345-016-1957-5

    Article  PubMed  Google Scholar 

  60. Netsch C, Engbert A, Bach T, Gross AJ (2014) Long-term outcome following Thulium VapoEnucleation of the prostate. World J Urol 32:1551–1558. https://doi.org/10.1007/s00345-014-1260-2

    Article  CAS  PubMed  Google Scholar 

  61. Yang Z, Liu T, Wang X (2016) Comparison of thulium laser enucleation and plasmakinetic resection of the prostate in a randomized prospective trial with 5-year follow-up. Lasers Med Sci 31:1797–1802. https://doi.org/10.1007/s10103-016-2052-2

    Article  PubMed  Google Scholar 

  62. Becker B, Buttice S, Magno C et al (2018) Thulium vaporesection of the prostate and thulium vapoenucleation of the prostate: a retrospective bicentric matched-paired comparison with 24-month follow-up. UrolInt 100:105–111. https://doi.org/10.1159/000484444

    Article  CAS  Google Scholar 

  63. Castellani D, Saredi G, Pirola GM et al (2018) Comparison between two different en bloc thulium laser enucleation of the prostate: does technique influence complications and outcomes? Urology 119:121–126. https://doi.org/10.1016/j.urology.2018.05.024

    Article  PubMed  Google Scholar 

  64. Feng L, Zhang D, Tian Y, Song J (2016) Thulium laser enucleation versus plasmakinetic enucleation of the prostate: a randomized trial of a single center. J Endourol 30:665–670. https://doi.org/10.1089/end.2015.0867

    Article  PubMed  Google Scholar 

  65. Zhang F, Shao Q, Herrmann TRW et al (2012) Thulium laser versus holmium laser transurethral enucleation of the prostate: 18-month follow-up data of a single center. Urology 79:869–874. https://doi.org/10.1016/j.urology.2011.12.018

    Article  PubMed  Google Scholar 

  66. Hong K, Liu Y-Q, Lu J et al (2015) Efficacy and safety of 120-W thulium: yttrium-aluminum-garnet vapoenucleation of prostates compared with holmium laser enucleation of prostates for benign prostatic hyperplasia. Chin Med J 128:884–889. https://doi.org/10.4103/0366-6999.154282

    Article  PubMed  PubMed Central  Google Scholar 

  67. Pirola GM, Saredi G, Codas Duarte R et al (2018) Holmium laser versus thulium laser enucleation of the prostate: a matched-pair analysis from two centers. TherAdvUrol 10:223–233. https://doi.org/10.1177/1756287218779784

    Article  CAS  Google Scholar 

  68. Gu M, Liu C, Chen Y et al (2018) Comparison of Vela and holmium laser enucleation of the prostate: a retrospective clinical trial with a 12-month follow-up. IntUrolNephrol 50:819–823. https://doi.org/10.1007/s11255-018-1840-y

    Article  CAS  Google Scholar 

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Protocol/project development: TH. Data collection or management: BB, GB, TH, CN, TB, DE, and AG. Data analysis: BB, CN. Manuscript writing/editing: BB, CN, and AG. Manuscript overview: TH, GB, TB, and DE.

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Correspondence to B. Becker.

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Becker, B., Netsch, C., Bozzini, G. et al. Reasons to go for thulium-based anatomical endoscopic enucleation of the prostate. World J Urol 39, 2363–2374 (2021). https://doi.org/10.1007/s00345-021-03704-7

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