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Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database

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Abstract

Purpose

To investigate gender differences in clinicopathological features and to analyze the prognostic impact of gender in renal cell carcinoma (RCC) patients undergoing surgery.

Methods

A total of 6,234 patients (eleven centers; Europe and USA) treated by radical or partial nephrectomy were included in this retrospective study (median follow-up 59 months; IQR 30–106). Gender differences in clinicopathological parameters were assessed. Multivariable Cox regression models were applied to determine the influence of parameters on disease-specific survival (DSS) and overall survival (OS).

Results

A total of 3,751 patients of the study group were male patients (60.2 %), who were significantly younger at diagnosis and received more frequently NSS than women. Significantly, more often high-grade tumors and simultaneous metastasis were present in men. Whereas tumor size and pTN stages did not differ between genders, clear-cell and chromophobe RCC was diagnosed less frequently, but papillary RCC more often in men. Gender also independently influenced DSS (HR 0.75, p < 0.001) and OS (HR 0.80, p < 0.001) with a benefit for women. However, inclusion of gender in multivariable models did not significantly gain predictive accuracies (PA) for DSS (0.868–0.870, p = 0.628) and OS (0.775–0.777, p = 0.522). Furthermore, no significantly different DSS and OS rates were found in patients undergoing NSS.

Conclusions

This study demonstrates important gender differences in clinicopathological features and outcome of RCC patients with improved DSS and OS for women compared to men, even if solely patients with clear-cell RCC or M0-stage are taken into evaluation. However, inclusion of gender in multivariable models does not significantly gain PA of multivariable models.

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References

  1. Pierorazio PM, Murphy AM, Benson MC, McKiernan JM (2007) Gender discrepancies in the diagnosis of renal cortical tumors. World J Urol 25(1):81–85

    Article  PubMed  Google Scholar 

  2. Aron M, Nguyen MM, Stein RJ, Gill IS (2008) Impact of gender in renal cell carcinoma: an analysis of the SEER database. Eur Urol 54(1):133–140

    Article  PubMed  Google Scholar 

  3. Stafford HS, Saltzstein SL, Shimasaki S, Sanders C, Downs TM, Sadler GR (2008) Racial/ethnic and gender disparities in renal cell carcinoma incidence and survival. J Urol 179(5):1704–1708

    Article  PubMed  Google Scholar 

  4. Woldrich JM, Mallin K, Ritchey J, Carroll PR, Kane CJ (2008) Sex differences in renal cell cancer presentation and survival: an analysis of the National Cancer Database, 1993–2004. J Urol 179(5):1709–1713

    Article  PubMed  Google Scholar 

  5. Schrader AJ, Sevinc S, Olbert PJ, Hegele A, Varga Z, Hofmann R (2008) Gender-specific characteristics and survival of renal cell carcinoma. Urologe 47(9):1182, 1184–6

    Google Scholar 

  6. Chen J, Shi B, Zhang D, Jiang X, Xu Z (2009) The clinical characteristics of renal cell carcinoma in female patients. Int J Urol 16(6):554–557

    Article  PubMed  Google Scholar 

  7. Lee S, Jeon HG, Kwak C, Kim HH, Byun SS, Lee SE, Lee E (2012) Gender-specific clinicopathological features and survival in patients with renal cell carcinoma (RCC). BJU Int 110:28–33

    Article  Google Scholar 

  8. Hew MN, Zonneveld R, Kümmerlin IP, Opondo D, de la Rosette JJ, Laguna MP (2012) Age and gender related differences in renal cell carcinoma in a European cohort. J Urol 188(1):33–38

    Article  PubMed  Google Scholar 

  9. Greene FL, Gospodarowicz M, Wittekend C et al (2009) American Joint Committee on Cancer (AJCC) staging manual, 7th edn. Springer, Philadelphia

    Google Scholar 

  10. Fuhrman S, Lasky LC, Limas L (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655–663

    Article  PubMed  CAS  Google Scholar 

  11. Kovacs G, Akhtar M, Beckwith BJ et al (1997) The Heidelberg classification of renal cell tumours. J Pathol 183(2):131–133

    Article  PubMed  CAS  Google Scholar 

  12. Brookman-May S, May M, Ficarra V et al (2012) Does preoperative platelet count and thrombocytosis play a prognostic role in patients undergoing nephrectomy for renal cell carcinoma? Results of a comprehensive retrospective series. World J Urol. doi:10.1007/s00345-012-0931-0

    Google Scholar 

  13. Harrell FE Jr, Lee KL, Mark DB (1996) Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 15:361–387

    Article  PubMed  Google Scholar 

  14. Murai M (2008) Editorial comment on: impact of gender in renal cell carcinoma: an analysis of the SEER database. Eur Urol 54(1):140–141

    Article  PubMed  Google Scholar 

  15. Sun M, Shariat SF, Cheng C et al (2011) Prognostic factors and predictive models in renal cell carcinoma: a contemporary review. Eur Urol 60(4):644–661

    Article  PubMed  Google Scholar 

  16. Langner C, Ratschek M, Rehak P et al (2004) Steroid hormone receptor expression in renal cell carcinoma: an immunohistochemical analysis of 182 tumors. J Urol 171(2 Pt 1):611–614

    Article  PubMed  CAS  Google Scholar 

  17. Eichelberg C, Minner S, Isbarn H et al (2011) Prognostic value of alpha-methyl CoA racemase (AMACR) expression in renal cell carcinoma. World J Urol. doi:10.1007/s00345-011-0783-z

    PubMed  Google Scholar 

  18. Costa WH, Rocha RM, Cunha IW, Fonseca FP, Guimaraes GC, Zequi Sde C (2012) CD133 immunohistochemical expression predicts progression and cancer-related death in renal cell carcinoma. World J Urol 30(4):553–558

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, St. Elisabeth Hospital Straubing, Straubing, Germany

    Matthias May & Christian Gilfrich

  2. Department of Urology, Caritas St. Josef Medical School, University of Regensburg, Regensburg, Germany

    Atiqullah Aziz, Anette Stoltze, Fabian Fenske & Hans-Martin Fritsche

  3. Department of Urology, Medical University of Graz, Graz, Austria

    Richard Zigeuner, Thomas Chromecki & Orietta Dalpiaz

  4. Department of Urology, Pio Da Pietrelcina Hospital, Vasto, Italy

    Luca Cindolo & Luigi Schips

  5. Division of Urology, European Institute of Oncology, Milan, Italy

    Ottavio De Cobelli

  6. Department of Urology, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy

    Bernardo Rocco

  7. Department of Urology, Faculty of Health Sciences, University “La Sapienza”, Ospedale Sant’Andrea, Rome, Italy

    Cosimo De Nunzio & Andrea Tubaro

  8. Department of Urology, Clinical Municipal Hospital, Cluj-Napoca, Romania

    Ioman Coman

  9. Department of Urology, Klinikum Dortmund, Dortmund, Germany

    Michael Truss & Orietta Dalpiaz

  10. Department of Urology, Carl-Thiem-Klinikum Cottbus, Cottbus, Germany

    Bernd Hoschke

  11. Department of Urology, Emergency Hospital Satu Mare, Satu Mare, Romania

    Bogdan Feciche

  12. Department of Surgery, Division of Urologic Surgery, Washington University School of Medicine, St. Louis, WA, USA

    Robert S. Figenshau & Kerry Madison

  13. Department of Urology, Alcala de Henares, Hospital Universitario Principe de Asturias, Madrid, Spain

    Manuel Sánchez-Chapado & Maria del Carmen Santiago Martin

  14. Department of Urology, G. Rummo Hospital, Benevento, Italy

    Luigi Salzano & Giuseppe Lotrecchiano

  15. Department of Urology, University Hospitals Leuven, Leuven, Belgium

    Steven Joniau

  16. Department of Development and Regeneration, KU Leuven, Leuven, Belgium

    Steven Joniau

  17. Department of Urology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany

    Raphaela Waidelich, Christian Stief & Sabine Brookman-May

Authors
  1. Matthias May
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  2. Atiqullah Aziz
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  3. Richard Zigeuner
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  4. Thomas Chromecki
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  5. Luca Cindolo
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  6. Luigi Schips
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  7. Ottavio De Cobelli
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  8. Bernardo Rocco
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  9. Cosimo De Nunzio
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  10. Andrea Tubaro
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  11. Ioman Coman
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  12. Michael Truss
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  13. Orietta Dalpiaz
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  14. Bernd Hoschke
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  15. Christian Gilfrich
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  16. Bogdan Feciche
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  17. Anette Stoltze
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  18. Fabian Fenske
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  19. Hans-Martin Fritsche
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  20. Robert S. Figenshau
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  21. Kerry Madison
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  22. Manuel Sánchez-Chapado
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  23. Maria del Carmen Santiago Martin
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  24. Luigi Salzano
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  25. Giuseppe Lotrecchiano
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  26. Steven Joniau
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  27. Raphaela Waidelich
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  28. Christian Stief
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  29. Sabine Brookman-May
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Consortia

Members of the CORONA project the Young Academic Urologists Renal Cancer Group

Corresponding author

Correspondence to Sabine Brookman-May.

Additional information

Matthias May and Atiqullah Aziz have equally contributed to first authorship.

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May, M., Aziz, A., Zigeuner, R. et al. Gender differences in clinicopathological features and survival in surgically treated patients with renal cell carcinoma: an analysis of the multicenter CORONA database. World J Urol 31, 1073–1080 (2013). https://doi.org/10.1007/s00345-013-1071-x

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  • DOI: https://doi.org/10.1007/s00345-013-1071-x

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