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Cosmid-derived markers anchoring the bovine genetic map to the physical map

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Abstract

The mapping strategy for the bovine genome described in this paper uses large insert clones as a tool for physical mapping and as a source of highly polymorphic microsatellites for genetic typing, and was one objective of the BovMap Project funded by the European Union (UE). Eight-three cosmid and phage clones were characterized and used to physically anchor the linkage groups defining all the bovine autosomes and the X Chromosome (Chr). By combining physical and genetic mapping, clones described in this paper have led to the identification of the linkage groups corresponding to Chr 9, 12, 16, and 25. In addition, anchored loci from this study were used to orient the linkage groups corresponding to Chr 3, 7, 8, 9, 13, 16, 18, 19, and 28 as identified in previously published maps. Comparison of the estimated size of the physical and linkage maps suggests that the genetic length of the bovine genome may be around 4000 cM.

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Authors and Affiliations

  1. IDVGA-CNR, 20133, Milan, Italy

    L. Ferretti, B. Castiglioni, A. Mezzelani & Y. Zhang

  2. Roslin Institute (Edinburgh), EH25 9PS, Roslin, Midlothian, Scotland, UK

    B. G. D. Urquhart, A. L. G. Morgan, V. M. Teres & J. L. Williams

  3. Laboratoire de Génétique biochimique et de Cytogénétique, INRA-CRJ, 78350, Jouy-en-Josas, France

    A. Eggen, E. P. Cribiu & H. Leveziel

  4. Department of Morphology, Genetics and Aquatic Biology, Norwegian College of Veterinary Medicine, 0033, Oslo, Norway

    I. Olsaker

  5. Department of Animal Breeding and Genetics, Hannover School of Veterinary Sciences, 30559, Hannover, Germany

    B. Harlizius & U. Thieven

  6. Swiss Federal Institute of Technology (ETH), Section Animal Breeding, 8092, Zurich, Switzerland

    S. Solinas Toldo & R. Fries

  7. Dipartimento di Genetica e Microbiologia, via Abbiategrasso 207, Università degli Studi di Pavia, 27100, Pavia, Italy

    L. Ferretti & Y. Zhang

  8. Department of Molecular Genetics, Research Centre of Animal Production, Rostock-Dummerstorf, 18196, Dummerstorf, Germany

    M. Schwerin

  9. Laboratorio de Genétíca Bioquimica, Facultad de Veterinaria, E-50013, Zaragoza, Spain

    I. Martin-Burriel

  10. Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S-750 07, Uppsala, Sweden

    B. P. Chowdhary

  11. Department of Animal Breeding and Genetics, Justus-Liebig University, 35390, Giessen, Germany

    G. Erhardt

  12. Lehrstuhl fuer Tierzucht, Technische Universitaet Muenchen-Weihenstephan, 85350, Freising, Germany

    R. Fries

  13. Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, 3508, Utrecht, TD, The Netherlands

    I. J. Nijman

  14. CSIRO Division of Tropical Animal Production, University of Queensland, 4072, Brisbane, Australia

    W. Barendse

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  1. L. Ferretti
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  2. B. G. D. Urquhart
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  3. A. Eggen
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  4. I. Olsaker
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  5. B. Harlizius
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  6. B. Castiglioni
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  8. S. Solinas Toldo
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  9. U. Thieven
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  10. Y. Zhang
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  11. A. L. G. Morgan
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  12. V. M. Teres
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  13. M. Schwerin
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  14. I. Martin-Burriel
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  15. B. P. Chowdhary
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  17. I. J. Nijman
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  18. E. P. Cribiu
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  19. W. Barendse
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  20. H. Leveziel
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  21. R. Fries
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  22. J. L. Williams
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Ferretti, L., Urquhart, B.G.D., Eggen, A. et al. Cosmid-derived markers anchoring the bovine genetic map to the physical map. Mammalian Genome 8, 29–36 (1997). https://doi.org/10.1007/s003359900341

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