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The value of a rapid contrast-enhanced angio-MRI protocol in the detection of head and neck paragangliomas in SDHx mutations carriers: a retrospective study on behalf of the PGL.EVA investigators*

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Abstract

Objectives

To assess the performance of a simplified MRI protocol consisting of a contrast-enhanced three-dimensional MR angiography (CE-MRA) in association with a post-contrast T1-weighted sequence (T1WIV) for the detection of HNPGLs in SDHx mutation carriers.

Methods

This retrospective sub-study is based on the multicenter PGL.EVA cohort, which prospectively enrolled SDHx mutation carriers from 2005 to 2009; 157 index cases or relatives were included. CE-MRA and the T1WIV images were read solely with knowledge of the clinical data but blind to the diagnosis. Sensitivity, specificity and likelihood ratios for the simplified MRI protocol were compared to the full MRI protocol reading results and to the gold standard status obtained through the consensus of an expert committee.

Results

The sensitivity and specificity of the readings of the simplified MRI protocol were, respectively, 88.7 % (95 % CI = 78.1–95.3) and 93.7 % (95 % CI = 86.8–97.7) versus 80.7 % (95 % CI = 68.6–89.6) and 94.7 % (95 % CI = 88.1–98.3) for the readings of the full MRI protocol.

Conclusions

The simplified post-contrast MRI with shorter duration (5 to 10 minutes) showed no performance difference compared to the lengthy standard full MRI and can be proposed for the detection of head and neck paragangliomas (HNPGLs) in SDHx mutation carriers.

Key Points

• Rapid angio-MRI protocol and the usual lengthy protocol show equal diagnostic performance.

• The CE-MRA is the key sequence for the detection of HNPGLs.

• The T1WIV sequence assists in localizing HNPGLs.

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Abbreviations

HNPGL:

Head and neck paraganglioma

CE-MRA:

Contrast-enhanced three-dimensional MR angiography

T1WIV:

Post-contrast T1-weighted sequence

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Acknowledgments

Authors would like to thank Steven M. Yevich for editing the English text. The scientific guarantor of this publication is Prof. Philippe Halimi. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by Program Hospitalier National de Recherche Clinique 2004 (PCR05007).

One of the authors has significant statistical expertise: Aurore Caumont-Prim from Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité d’Épidémiologie et de Recherche Clinique, F-75015 Paris, France. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Some study subjects or cohorts have been previously reported in: Gimenez-Roqueplo A-P, Caumont-Prim A, Houzard C, et al. (2013) Imaging work-up for screening of paraganglioma and pheochromocytoma in SDHx mutation carriers: a multicenter prospective study from the PGL.EVA Investigators. J Clin Endocrinol Metab 98:E162–173. Methodology: retrospective, diagnostic study, multicenter study.

Author information

Authors and Affiliations

  1. Assistance Publique-Hôpitaux de Paris, Service de Radiologie, Hôpital Européen Georges Pompidou, F-75015, Paris, France

    Guillaume Gravel, Anne Hernigou & Philippe Halimi

  2. Assistance Publique-Hôpitaux de Marseille, Service d’Endocrinologie, Diabète et Maladies Métaboliques, Centre Hospitalier Universitaire la Timone, F-13000, Marseille, France

    Patricia Niccoli

  3. Service d’Endocrinologie, Diabétologie, Nutrition, Centre Hospitalier Universitaire d’Angers, F-49933, Angers, France

    Vincent Rohmer

  4. LUNAM Université, INSERM, U1063, F-49933, Angers, France

    Vincent Rohmer

  5. Assistance Publique-Hôpitaux de Marseille, Service de Radiologie, Centre Hospitalier Universitaire la Timone, F-13000, Marseille, France

    Guy Moulin

  6. Hospices civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, F-69003, Lyon, France

    Françoise Borson-Chazot

  7. Faculté de Médecine Lyon-Est, Université de Lyon, F-69372, Lyon, France

    Françoise Borson-Chazot

  8. INSERM UMR1052, UMR CNRS 5286, Cancer Research Center of Lyon, F-69008, Lyon, France

    Françoise Borson-Chazot

  9. Groupement Hospitalier Est, Service de Radiologie, Hospices civils de Lyon, F-69003, Lyon, France

    Pascal Rousset

  10. Service de Radiologie, Centre Hospitalier Universitaire d’Angers, F-49933, Angers, France

    Anne Pasco-Papon

  11. Service de Radiologie, Centre Hospitalo-Universitaire de Reims, F-51000, Reims, France

    Claude Marcus

  12. Service de Radiologie, Centre Hospitalo-Universitaire de Lille, F-59000, Lille, France

    Frédérique Dubrulle

  13. Assistance Publique-Hôpitaux de Paris, Service de Radiologie, Hôpital Cochin, F-75006, Paris, France

    Hervé Gouya

  14. Service de Radiologie, Institut Gustave Roussy, F-94800, Villejuif, France

    François Bidault

  15. Service de Radiologie, Centre Hospitalo-Universitaire de Nantes, F-44000, Nantes, France

    Benoit Dupas

  16. Service de Neuroradiologie, Centre Hospitalo-Universitaire de Clermont-Ferrand, F-63000, Clermont Ferrand, France

    Jean Gabrillargues

  17. Assistance Publique-Hôpitaux de Paris, Service de Génétique, Hôpital Européen Georges Pompidou, 20-40, rue Leblanc, 75015, Paris, France

    Anne-Paule Gimenez-Roqueplo

  18. INSERM, UMR970, Paris Cardiovascular Research Center, F-75015, Paris, France

    Anne-Paule Gimenez-Roqueplo

  19. Sorbonne Paris Cité, Faculté de Médecine, Université Paris Descartes, F-75006, Paris, France

    Anne-Paule Gimenez-Roqueplo & Philippe Halimi

  20. Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité d’Épidémiologie et de Recherche Clinique, F-75015, Paris, France

    Aurore Caumont-Prim

  21. INSERM, Centre d’investigation Épidémiologique 4, F-75015, Paris, France

    Aurore Caumont-Prim

Authors
  1. Guillaume Gravel
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  2. Patricia Niccoli
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  3. Vincent Rohmer
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  4. Guy Moulin
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  7. Anne Pasco-Papon
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  8. Claude Marcus
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  11. François Bidault
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  13. Jean Gabrillargues
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  14. Aurore Caumont-Prim
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  15. Anne Hernigou
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  16. Anne-Paule Gimenez-Roqueplo
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  17. Philippe Halimi
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Corresponding author

Correspondence to Anne-Paule Gimenez-Roqueplo.

Additional information

Anne-Paule Gimenez-Roqueplo and Philippe Halimi jointly directed this work.

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Gravel, G., Niccoli, P., Rohmer, V. et al. The value of a rapid contrast-enhanced angio-MRI protocol in the detection of head and neck paragangliomas in SDHx mutations carriers: a retrospective study on behalf of the PGL.EVA investigators*. Eur Radiol 26, 1696–1704 (2016). https://doi.org/10.1007/s00330-015-4024-5

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  • DOI: https://doi.org/10.1007/s00330-015-4024-5

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