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Sixty-four-slice multidetector computed tomography for preoperative evaluation of left ventricular function and mass in patients with mitral regurgitation: comparison with magnetic resonance imaging and echocardiography

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Abstract

Quantitative values of left ventricular (LV) function and muscle mass in patients with mitral regurgitation are independent predictors of cardiac morbidity and mortality. The aim of this study was to prospectively evaluate whether 64-MDCT can assess the LV function in patients with mitral regurgitation with high accuracy when compared with the MRI and echocardiography results. Fifty-one patients with mitral regurgitation underwent retrospectively ECG-gated 64-MDCT, echocardiography, and MRI for assessing the global ventricular function. End-diastolic and end-systolic volume, stroke volume, ejection fraction, and mass were measured on 64-MDCT and echocardiography, and compared with the results measured on MRI which served as the reference standard. Intertechnique agreement was tested by using Pearson’s correlation and Bland–Altman analyses. No significant differences were revealed in calculated LV function and mass between the 64-MDCT and MRI (paired t test, p = 0.07–0.53). Pearson’s correlation analysis showed the functional parameters and mass correlated closely between the 64-MDCT and MRI (r = 0.89–0.96, p < 0.001). When compared with MRI, echocardiography underestimated the volumetric parameters of LV (paired t test, p = 0.0003–0.004), but significantly overestimated the EF values (p = 0.003), and moderate correlations of functional parameters were obtained (r = 0.78, 0.60, 0.81, and 0.62, respectively). ECG-gated 64-MDCT allows for accurate and reliable assessment of LV function in patients with mitral regurgitation, whereas LV volumes measured by two-dimensional echocardiography were underestimated and the ejection fraction was overestimated when compared with those achieved by using MRI.

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Authors and Affiliations

  1. Department of Medical Imaging, West China Second University Hospital, Sichuan University, 20#, Section 3, South Renmin Road, Chengdu, Sichuan, 610041, China

    Ying-kun Guo & Gang Ning

  2. Department of Radiology, West China Hospital, Sichuan University, 37#, Guo Xue Xiang, Chengdu, Sichuan, 610041, China

    Ying-kun Guo, Zhi-gang Yang, Xiao-chun Zhang & Qi-ling Wang

  3. National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37#, Guo Xue Xiang, Chengdu, Sichuan, 610041, China

    Zhi-gang Yang

  4. Department of Cardiology, West China Hospital, Sichuan University, 37#, Guo Xue Xiang, Chengdu, Sichuan, 610041, China

    Li Rao, Ying Pen & Yang Wu

  5. Department of Thoracic and Cardiovascular Surgery, West China Hospital, Sichuan University, 37#, Guo Xue Xiang, Chengdu, Sichuan, 610041, China

    Li Dong & Tai-ming Zhang

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  1. Ying-kun Guo
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Correspondence to Zhi-gang Yang.

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Guo, Yk., Yang, Zg., Ning, G. et al. Sixty-four-slice multidetector computed tomography for preoperative evaluation of left ventricular function and mass in patients with mitral regurgitation: comparison with magnetic resonance imaging and echocardiography. Eur Radiol 19, 2107–2116 (2009). https://doi.org/10.1007/s00330-009-1392-8

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