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Hyperpolarized 3helium magnetic resonance ventilation imaging of the lung in cystic fibrosis: comparison with high resolution CT and spirometry

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Abstract

The purpose of this study was to compare hyperpolarized 3helium magnetic resonance imaging (3He MRI) of the lungs in adults with cystic fibrosis (CF) with high-resolution computed tomography (HRCT) and spirometry. Eight patients with stable CF prospectively underwent 3He MRI, HRCT, and spirometry within 1 week. Three-dimensional (3D) gradient-echo sequence was used during an 18-s breath-hold following inhalation of hyperpolarized 3He. Each lung was divided into six zones; 3He MRI was scored as percentage ventilation per lung zone. HRCT was scored using a modified Bhalla scoring system. Univariate (Spearman rank) and multivariate correlations were performed between 3He MRI, HRCT, and spirometry. Results are expressed as mean±SD (range). Spirometry is expressed as percent predicted. There were four men and four women, mean age=31.9±9 (20–46). Mean forced expiratory volume in 1 s (FEV)1=52%±29 (27–93). Mean 3He MRI score=74%±25 (55–100). Mean HRCT score=48.8±24 (13.5–83). The correlation between3He MRI and HRCT was strong (R=±0.89, p<0.001). Bronchiectasis was the only independent predictor of 3He MRI; 3He MRI correlated better with FEV1 and forced vital capacity (FVC) (R=0.86 and 0.93, p<0.01, respectively) than HRCT (R=±0.72 and ±0.81, p<0.05, respectively). This study showed that 3He MRI correlates strongly with structural HRCT abnormalities and is a stronger correlate of spirometry than HRCT in CF.

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Acknowledgements

This study was funded by the Cystic Fibrosis Research Trust Fund of Ireland and the Academic Research Fund of the Department of Radiology, St. Vincent’s University Hospital. Technical development was funded in part by EPSRC, UK #GR/S81834/01(P) and European Framework V project Polarized Helium for Imaging the Lungs. We acknowledge GE Healthcare for loan of our polarizer and Spectra Gases for support with gas. We thank Sally Fleming and Sharon Rothwell for helping with patient care. We thank all patients for their participation.

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Authors and Affiliations

  1. Department of Radiology, St. Vincent’s University Hospital, Dublin 4, Ireland

    Colm J. McMahon, Jonathan D. Dodd, Stephen J. Skehan & James B. Masterson

  2. Department of National Referral Centre for Adult Cystic Fibrosis, St. Vincent’s University Hospital, Dublin 4, Ireland

    Charles G. Gallagher

  3. The Unit of Academic Radiology, University of Sheffield, Royal Hallamshire Hospital, Sheffield, England, UK

    Catherine Hill, Neil Woodhouse, Jim M. Wild, Stan Fichele & Edwin J. R. van Beek

  4. Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

    Edwin J. R. van Beek

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  1. Colm J. McMahon
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  2. Jonathan D. Dodd
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  3. Catherine Hill
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  4. Neil Woodhouse
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  5. Jim M. Wild
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  9. Edwin J. R. van Beek
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Correspondence to Colm J. McMahon.

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McMahon, C.J., Dodd, J.D., Hill, C. et al. Hyperpolarized 3helium magnetic resonance ventilation imaging of the lung in cystic fibrosis: comparison with high resolution CT and spirometry. Eur Radiol 16, 2483–2490 (2006). https://doi.org/10.1007/s00330-006-0311-5

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  • DOI: https://doi.org/10.1007/s00330-006-0311-5

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