Abstract
The potential relative beneficial aspects of upright, weight-bearing (pMRI), dynamic–kinetic (kMRI) spinal imaging over that of recumbent MRI (rMRI) include the revelation of occult spinal disease dependent on true axial loading, the unmasking of kinetic-dependent spinal disease and the ability to scan the patient in the position of clinically relevant signs and symptoms. This imaging unit under study also demonstrated low claustrophobic potential and yielded comparatively high resolution images with little motion/magnetic susceptibility/chemical shift artifact. Overall, it was found that rMRI underestimated the presence and maximum degree of gravity-dependent spinal pathology and missed altogether pathology of a dynamic nature, factors that are optimally revealed with p/kMRI. Furthermore, p/kMRI enabled optimal linkage of the patient’s clinical syndrome with the medical imaging abnormality responsible for the clinical presentation, thereby allowing for the first time an improvement at once in both imaging sensitivity and specificity.













Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.References
Jinkins JR, Dworkin JS, Green CA, Greenhalgh JF, Gianni M, Gelbein M, Wolf R, Damadian J, Damadian RV (2002) Upright, weight-bearing, dynamic–kinetic MRI of the spine: pMRI/kMRI. Riv Neuroradiol 15:333–356
Jinkins JR, Dworkin JS, Green CA, Greenhalgh JF, Gianni M, Gelbein M, Wolf R, Damadian J, Damadian RV (2003) Upright, weight-bearing, dynamic–kinetic magnetic resonance imaging of the spine—review of the first clinical results. J Hong Kong Coll Radiol 6:55–74
Smith TJ, Fernie GR (1991) Functional biomechanics of the spine. Spine 16:1197–1203
Smith TJ (1991) In vitro spinal biomechanics: experimental methods and apparatus. Spine 16:1204–1210
Marras WS, Granata KP (1995) A biomechanical assessment and model of axial twisting in the thoracolumbar spine. Spine 20:1440–1451
Resnick DK, Weller SJ, Benzel EC (1997) Biomechanics of the thoracolumbar spine. Neurosurg Clin N Am 8:455–469
Berne D, Goubier JN, Lemoine J et al (1999) The aging of the spine. Eur J Orthop Surg Traumatol 9:125–133
Boden SD, Wiesel SW (1990) Lumbosacral segmental motion in normal individuals: have we been measuring instability properly? Spine 15:571–576
Danielson BI, Willén J, Gaulitz A et al (1998) Axial loading of the spine during CT and MR in patients with suspected lumbar spinal stenosis. Acta Radiol 39:604–611
Frymoyer JW, Frymoyer WW, Wilder DG et al (1979) The Mechanical and kinematic analysis of the lumbar spine in normal living human subjects in vivo. J Biomech 12:165–172
Hedman TP, Fernie GR (1995) In vivo measurement of lumbar spinal creep in two seated postures using magnetic resonance imaging. Spine 20:178–183
Hilton RC, Ball J, Benn RT (1979) In-vitro mobility of the lumbar spine. Ann Rheum Dis 38:378–383
Inufusa A, An HS, Lim T-H et al (1996) Anatomic changes of the spinal canal and intervertebral foramen associated with flexion–extension movement. Spine 21:2412–2420
Mayoux-Benhamou MA, Revel M, Aaron C et al (1989) A morphometric study of the lumbar foramen: influence of flexion–extension movements and of isolated disc collapse. Surg Radiol Anat 11:97–102
Nachemson AL, Schultz AB, Berkson MH (1979) Mechanical properties of human lumbar spine motion segments: influences of age, sex, disc level, and degeneration. Spine 4:1–8
Nowicki BH, Haughton VM, Schmidt TA et al (1996) Occult lumbar lateral spinal stenosis in neural foramina subjected to physiologic loading. Am J Nueroradiol 17:1605–1614
Pennal GF, Conn GS, McDonald G et al (1972) Motion studies of the lumbar spine: a preliminary report. J Bone Jt Surg 54B:442–452
Penning L, Wilmink JT (1987) Posture-dependent bilateral compression of L4 or L5 nerve roots in facet hypertrophy: a dynamic CT-myelographic study. Spine 12:488–500
Schönström N, Lindahl S, Willén J et al (1989) Dynamic changes in the dimensions of the lumbar spinal canal: an experimental study in vitro. J Orthop Res 7:115–121
Sortland O, Magnes B, Hauge T (1977) Functional myelography with metrizamide in the diagnosis of lumbar spinal stenosis. Acta Radiol 355(Suppl):42–54
White AS, Panjabi MM (1978) The basic kinematics of the human spine: a review of past and current knowledge. Spine 3:12–29
Willén J, Danielson B, Gaulitz A et al (1997) Dynamic effects on the lumbar spinal canal: axially loaded CT-myelography and MRI in patients with sciatica and/or neurogenic claudication. Spine 22:2968–2976
Wilmink JT, Penning L, van den Burg W (1984) Role of stenosis of spinal canal in L4–L5 nerve root compression assessed by flexion–extension myelography. Neuroradiology 26:173–181
Friberg O (1987) Lumbar instability. A dynamic approach by traction–compression radiography. Spine 12:119–20
Fujiwara A, An HS, Lim TH et al (2001) Morphologic changes in the lumbar intervertebral foramen due to flexion–extension, lateral bending, and axial rotation: an in vitro anatomic and biomechanical study. Spine 26:876–882
Hayes MA, Howard TC, Gruel CR et al (1989) Roentgenographic evaluation of lumbar spine flexion–extension in asymptomatic individuals. Spine 14:327–331
Lee RR, Abraham RA, Quinn CB (2001) Dynamic physiologic changes in lumbar CSF volume quantitatively measured by three-dimensional fast spin-echo MRI. Spine 26:1172–1178
Panjabi MM, Takata K, Goel VK (1983) Kinematics of lumbar intervertebral foramen. Spine 8:348–357
Pearcy MJ, Tibrewal SB (1984) Axial rotation and lateral bending in the normal lumbar spine measured by three-dimensional radiography. Spine 9:582–587
Penning L, Wilmink JT (1981) Biomechanics of lumbosacral dural sac. A study of flexion–extension myelography. Spine 6:398–408
Revel M, Mayoux-Benhamou MA, Aaron C et al (1988) Morphological variations of the lumbar foramina. Rev Rhum Mal Osteo-artic 55:361–366
Stokes IA, Frymoyer JW (1987) Segmental motion and instability. Spine 12:688–691
Stokes IA, Wilder DG, Frymoyer JW et al (1981) Assessment of patients with low-back pain by biplanar radiographic measurement of intervertebral motion. Spine 6:233–240
Takayanagi K, Takahashi K, Yamagata M et al (2001) Using cineradiography for continuous dynamic-motion analysis of the lumbar spine. Spine 26:1858–1865
Wildermuth S, Zanetti M, Duewell S et al (1998) lumbar spine: quantitative and qualitative assessment of positional (upright flexion and extension) MR imaging and myelography. Radiology 207:391–398
Wisleder D, Smith MB, Mosher TJ et al (2001) Lumbar spine mechanical response to axial compression load in vivo. Spine 26:E403–E409
Wisleder D, Werner SL, Kraemer WJ et al (2001) A Method to study lumbar spine response to axial compression during magnetic resonance imaging. Spine 26:E416–E420
Zamani AA, Moriarty T, Hsu L et al (1998) Functional MRI of the lumbar spine in erect position in a superconducting open-configuration MR system: preliminary results. J Magn Reson Imaging 8:1329–1333
Leviseth G, Drerup B (1997) Spinal shrinkage during work in a sitting posture compared to work in a standing posture. Clin Biomech 12:409–418
Lowe RW, Hayes TD, Kaye J et al (1976) Standing roentgenograms in spondylolisthesis. Clin Orthop 117:80–84
Devor M, Rappaport ZH (1996) Relation of foraminal (lateral) stenosis to radicular pain. Am J Nueroradiol 17:1615–1617
Hasegawa T, An HS, Haughton VM et al (1995) Lumbar foraminal stenosis: critical heights of the intervertebral discs and foramina. J Bone Jt Surg 77-A:32–38
Pfirrmann CWA, Metzdorf A, Zanetti M (2001) Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 26:1873–1878
Shiwei Y, Haughton VM, Sether LA (1989) Criteria for classifying normal and degenerated lumbar intervertebral disks. Neuroradiology 170:523–526
Axelsson P, Johnson R, Strömqvist B (2000) Is there increased intervertebral mobility in isthmic adult spondylolisthesis? A matched comparative study using Roentgen stereophotogrammetry. Spine 25:1701–1703
Boden SD, Frymoyer JW (1997) Segmental instability: overview and classification. In: Frymoyer JW (ed) The adult spine: principles and practice. Lippincott-Raven, Philadelphia, pp 2137–2155
Dupuis PR, Yong-Hing K, Cassidy JD et al (1985) Radiologic diagnosis of degenerative lumbar spinal instability. Spine 10:262–276
Frymoyer JW, Selby DK (1985) Segmental instability: rationale for treatment. Spine 10:280–286
Fujiwara A, Lim T-H, An HS et al (2000) The effect of disc degeneration and facet joint osteoarthritis on the segmental flexibility of the lumbar spine. Spine 25:3036–3044
Pearcy M, Shepherd J (1985) Is there instability in spondylolisthesis? Spine 10:175–177
Ito M, Tadano S, Kaneda K (1993) A biomechanical definition of spinal segmental instability taking personal and disc level differences into account. Spine 18:2295–2304
Pope MH, Panjabi M (1985) Biomechanical definitions of spinal instability. Spine 10:255–256
Sato H, Kikuchi S (1993) The natural history of radiographic instability of the lumbar spine. Spine 18:2075–2079
Posner I, White AA, Edwards WT et al (1982) A biomechanical analysis of the clinical stability of the lumbar and lumbosacral spine. Spine 7:374–389
Wood KB, Popp CA, Transfeldt EE et al (1994) Radiographic evaluation of instability in spondylolisthesis. Spine 7:1697–1703
Yahia H, Drouin G, Maurais G et al (1989) Degeneration of the human lumbar spine ligaments. An ultrastructural study. Pathol Res Pract 184:369–375
Fujiwara A, Tamai K, An HS et al (2000) The interspinous ligament of the lumbar spine: magnetic resonance images and their clinical significance. Spine 25:358–363
Adams MA, Hutton WC, Stott JRR (1980) The resistance to flexion of the lumbar intervertebral joint. Spine 5:245–253
Dumas GA, Beaudoin L, Drouin G (1987) In situ mechanical behavior of posterior spinal ligaments in the lumbar region. An in vitro study. J Biomech 20:301–310
Hukins DWL, Kirby MC, Sikoryn TA et al (1990) Comparison of structure, mechanical properties, and functions of lumbar spinal ligaments. Spine 15:787–795
Panjabi MM (1992) The stabilizing system of the spine. Part 1. Function, dysfunction, adaptation, and enhancement. J Spinal Disord 5: 383–389
Panjabi MM, Goel VK, Takata K (1982) Physiologic strains in the lumbar spinal ligaments: an in vitro biomechanical study. Spine 7:192–203
Sharma M, Langrana NA, Rodriguez J (1995) Role of ligaments and facets in lumbar spinal stability. Spine 20:887–900
Fujiwara A, Lim TH, An HS (2000) The effect of disc degeneration and facet joint osteoarthritis on the segmental flexibility of the lumbar spine. Spine 25:3036–3044
Haughton VM, Schmidt TA, Keele K et al (2000) Flexibility of lumbar spinal motion segments correlated to type of tears in the annulus fibrosis. J Neurosurg 92:81–86
Thompson RE, Pearcy MJ, Downing KJW et al (2000) Disc lesions and the mechanics of the intervertebral joint complex. Spine 25:3026–3035
Twomey LT, Taylor JR (1983) Sagittal movements of the human lumbar vertebral column: a quantitative study of the role of the posterior vertebral elements. Arch Phys Med Rehabil 64:322–325
Cartolari R, Argento G, Cardello M et al (1999) Axial loaded computed tomography (AL-CT) and cine AL-CT. Riv Neuroradiol 12:33–44
Jinkins JR (1997) Posttherapeutic neurodiagnostic imaging. Lippincott-Raven, Philadelphia
Keller TS, Hansson TH, Holm SH et al (1989) In vivo creep behavior of the normal and degenerated porcine intervertebral disk: a preliminary report. J Spinal Disord 1:267–278
Jackson RP, Hales C (2000) Congruent spinopelvic alignment on standing lateral radiographs of adult volunteers. Spine 25:2808–2815
Lee C-S, Lee C-K, Kim Y-T et al (2001) Dynamic sagittal imbalance of the spine in degenerative flat back. Spine 26:2029–2035
Jackson RP, Kanemura T, Kawakami N et al (2000) Lumbopelvic lordosis and pelvic balance on repeated standing lateral radiographs of adult volunteers and untreated patients with constant low back pain. Spine 25:575–586
Jackson RP, Peterson MD, McManus AC et al (1998) Compensatory spinopelvic balance over the hip axis and better reliability in measuring lordosis to the pelvic radius on standing lateral radiographs of adult volunteers and patients. Spine 23:1750–1767
Stephens GC, Yoo JU, Wilbur G (1996) Comparison of lumbar sagittal alignment produced by different operative positions. Spine 21:1802–1807
Vitzthum H-E, Konig A, Seifert V (2000) Dynamic examination of the lumbar spine by suing vertical, open magnetic resonance imaging. J Neurosurg 93:58–64
Weishaupt D, Schmid MR, Zaneti M (2000) Positional MR imaging of the lumbar spine: does it demonstrated nerve root compromise not visible a conventional MR imaging? Radiology 215:247–253
Jinkins JR (2001) Acquired degenerative changes of the intervertebral segments at and suprajacent to the lumbosacral junction: a radioanatomic analysis of the nondiskal structures of the spinal column and perispinal soft tissues. Radiol Clin North Am 39:73–99
Jinkins JR (2004) Acquired degenerative changes of the intervertebral segments at and supradjacent to the lumbosacral junction: a radioanatomic analysis of the nondiscal structures of the spinal column and perispinal soft tissues. Eur J Radiol 50:134–158
Jinkins JR (2002) Lumbosacral interspinous ligament rupture associated with acute intrinsic spinal muscle degeneration. Eur Radiol 12:2370–2376
Mitra D, Cassar-Pullicino VN, McCall IW (2004) Longitudinal study of vertebral type-1 changes of MR of the lumbar spine. Eur Radiol 14:1084–1432
Acknowledgements
The authors gratefully acknowledge the technical assistance of C.A. Green, J.F. Greenhalgh, M. Gianni, M. Gelbien, R.B. Wolf, and J. Damadian.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jinkins, J.R., Dworkin, J.S. & Damadian, R.V. Upright, weight-bearing, dynamic–kinetic MRI of the spine: initial results. Eur Radiol 15, 1815–1825 (2005). https://doi.org/10.1007/s00330-005-2666-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-005-2666-4